BAY707)
- Product Name
- BAY707)
- CAS No.
- 2109805-96-9
- Chemical Name
- BAY707)
- Synonyms
- BAY707);BAY-707 (BAY 707;BAY-707 free base;1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]-
- CBNumber
- CB04844527
- Molecular Formula
- C15H20N4O2
- Formula Weight
- 288.34
- MOL File
- 2109805-96-9.mol
BAY707) Property
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:28.83(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:2.88(Max Conc. mg/mL);10.0(Max Conc. mM) - pka
- 14.36±0.40(Predicted)
- form
- Solid
- color
- Light yellow to khaki
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6562
- Product name
- BAY707
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 6562
- Product name
- BAY707
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $485
- Updated
- 2021/12/16
BAY707) Chemical Properties,Usage,Production
Biological Activity
BAY-707 is a substrate-competitive, highly selective inhibitor of MTH1(NUDT1) with IC50 of 2.3 nM. It has a favorable pharmacokinetic profile compared to other MTH1 compounds and is well tolerated in mice, but the experiments clearly lack in vitro or in vivo anticancer efficacy.
in vivo
Bay-077 (orally adminstation; 50-250 mg/kg; 2 weeks) exhibits superior biochemical potency, cellular target engagement, and a pharmacokinetic profile to other MTH1 tool compounds, But Bay-077 exerts no anticancer efficacy either in mono- or in combination therapies in CT26 and NCI-H460 mice model.
target
IC50: 2.3 nM (MTH1/NUDT1)
storage
Store at -20°C
BAY707) Preparation Products And Raw materials
Raw materials
Preparation Products
BAY707) Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38631
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58