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Olutasidenib

Product Name
Olutasidenib
CAS No.
1887014-12-1
Chemical Name
Olutasidenib
Synonyms
FT-2102;OLUTASIDENIB;Olutasidenib (FT-2102);Olutasidenib, 10 mM in DMSO;Olutasidenib (FT-2102) ，S8949;Olutasidenib (Synonyms: FT-2102);mutant,FT2102,inhibit,Isocitrate Dehydrogenase (IDH),Olutasidenib,2-HG,FT 2102,Inhibitor;(S)-5-[[1-(6-Chloro-2-oxo-1,2-dihydro-3-quinolyl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile;(S)-5-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile;5-[[(1S)-1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
CBNumber
CB04845034
Molecular Formula
C18H15ClN4O2
Formula Weight
354.79
MOL File
1887014-12-1.mol
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Olutasidenib Property

Boiling point:
603.3±55.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A crystalline solid
pka
10.44±0.70(Predicted)
color 
Light yellow to yellow
InChI
InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)23(2)18(16)25)14-8-11-7-12(19)3-5-15(11)22-17(14)24/h3-8,10,21H,1-2H3,(H,22,24)/t10-/m0/s1
InChIKey
NEQYWYXGTJDAKR-JTQLQIEISA-N
SMILES
C1(C#N)N(C)C(=O)C(N[C@H](C2=CC3=C(NC2=O)C=CC(Cl)=C3)C)=CC=1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0080183
Product name
Olutasidenib
Purity
98.35%
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0080183
Product name
Olutasidenib
Purity
98.35%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0080183
Product name
Olutasidenib
Purity
98.35%
Packaging
25mg
Price
$700
Updated
2021/12/16
ChemScene
Product number
CS-0080183
Product name
Olutasidenib
Purity
98.35%
Packaging
50mg
Price
$1100
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611286
Product name
Olutasidenib (FT-2102)
Purity
>98%
Packaging
100mg
Price
$1431.4
Updated
2021/12/16
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Olutasidenib Chemical Properties,Usage,Production

Uses

Olutasidenib (FT-2102) is a highly potent, orally active, brain penetrant and selective inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1), with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively . Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) [1][2].

Mechanism of action

Olutasidenib specifically inhibits the mutant IDH1 enzyme, which reduces the accumulation of abnormal metabolites and promotes normal differentiation and maturation of cells. This targeted treatment approach aims to reduce tumor burden and improve patient outcomes.

in vivo

Olutasidenib (FT-2102, three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals) exhibits potent anti-tumor activity in HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice[2].

Animal Model:HCT116-IDH1-R132H/+ xenograft bearing female BALB/c Nude mice[2].
Dosage:12.5, 25, and 50 mg/kg.
Administration:Three oral doses (12.5, 25, and 50 mg/kg) in 12-hour intervals.
Result:Showed a time and dose-dependent inhibition of 2-HG levels in in tumor.
At the highest dose tested in these studies (50 mg/kg), treatment with FT-2102 inhibited 2-HG levels in the tumor by >90% for up to 24 hours after the last dose in the HCT116-IDH1-R132H/+ xenograft model.

IC 50

IDH1

References

[1] JM Watts, et al. A phase 1 dose escalation study of the IDH1m inhibitor, FT-2102, in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
[2] Justin A. Caravella, et al. Structure-based design and identification of FT-2102 (olutasidenib), a potent mutant-selective IDH1 inhibitor. J Med Chem. 2020.

Olutasidenib Preparation Products And Raw materials

Raw materials

Preparation Products

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Olutasidenib Suppliers

CHINA 56 United States 4 Global 60
Chengdu Yuyang High-tech Development Co., Ltd.
Tel
0086-13852538605 13308012069
Email
13308012069@189.cn
Country
China
ProdList
37
Advantage
58
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Artis Biotech Co. Ltd.
Tel
028-67271278 18628360895
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
1960
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
Advantage
58
Shanghai Tube Pharmaceutical Co., Ltd.
Tel
021-54338626 18017892860
Fax
021-54338626
Email
sales@tubepharm.com
Country
China
ProdList
2572
Advantage
58
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
8497
Advantage
58

1887014-12-1, OlutasidenibRelated Search:


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  • (S)-5-[[1-(6-Chloro-2-oxo-1,2-dihydro-3-quinolyl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
  • (S)-5-((1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
  • Olutasidenib, 10 mM in DMSO
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  • API