3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo-
- Product Name
- 3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo-
- CAS No.
- 883564-93-0
- Chemical Name
- 3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo-
- Synonyms
- HOOCCH2O-PEG2-CH2COOtBu;13,13-dimethyl-11-oxo-3,6,9,12-tetraoxatetradecanoic acid;3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo-;13,13-Dimethyl-11-oxo-3,6,9,12-tetraoxatetradecan-1-oic acid;2-[2-[2-(2-tert-butoxy-2-oxo-ethoxy)ethoxy]ethoxy]acetic acid;2-[2-[2-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]ethoxy]ethoxy]acetic acid;HOOCCH2O-PEG2-CH2COOtBu/3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo-
- CBNumber
- CB04847407
- Molecular Formula
- C12H22O7
- Formula Weight
- 278.3
- MOL File
- 883564-93-0.mol
3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo- Property
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B-1369
- Product name
- HOOCCH2O-PEG2-CH2COOtBu
- Purity
- 97%
- Packaging
- 1g
- Price
- $550
- Updated
- 2021/12/16
- Product number
- AA01FVG6
- Product name
- t-butylacetate-PEG2-CH2COOH
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $695
- Updated
- 2021/12/16
- Product number
- AA01FVG6
- Product name
- t-butylacetate-PEG2-CH2COOH
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $1083
- Updated
- 2021/12/16
- Product number
- AA01FVG6
- Product name
- t-butylacetate-PEG2-CH2COOH
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $1608
- Updated
- 2021/12/16
3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo- Chemical Properties,Usage,Production
Description
t-butyl acetate-PEG2-CH2COOH is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
t-Butyl acetate-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
3,6,9,12-Tetraoxatetradecanoic acid, 13,13-dimethyl-11-oxo- Preparation Products And Raw materials
Raw materials
Preparation Products
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