t-butyl acetate-PEG3-CH2COOH
- Product Name
- t-butyl acetate-PEG3-CH2COOH
- CAS No.
- 1442466-57-0
- Chemical Name
- t-butyl acetate-PEG3-CH2COOH
- Synonyms
- HOOCCH2O-PEG3-CH2COOtBu;COOtBu-CH2-PEG3-OCH2COOH;t-butyl acetate-PEG3-CH2COOH;16,16-Dimethyl-14-oxo-3,6,9,12,15-pentaoxaheptadecanoic acid;3,6,9,12-Tetraoxatetradecanedioic acid, 1-(1,1-dimethylethyl) ester;HOOCCH2O-PEG3-CH2COOtBu/3,6,9,12-Tetraoxatetradecanedioic acid, 1-(1,1-dimethylethyl) ester
- CBNumber
- CB73129062
- Molecular Formula
- C14H26O8
- Formula Weight
- 322.35
- MOL File
- 1442466-57-0.mol
t-butyl acetate-PEG3-CH2COOH Property
- Boiling point:
- 435.6±35.0 °C(Predicted)
- Density
- 1.138±0.06 g/cm3(Predicted)
- pka
- 3.39±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AS107830
- Product name
- HOOCCH2O-PEG3-CH2COOtBu
- Purity
- 97%
- Packaging
- 250mg
- Price
- $396
- Updated
- 2021/12/16
- Product number
- AS107830
- Product name
- HOOCCH2O-PEG3-CH2COOtBu
- Purity
- 97%
- Packaging
- 1g
- Price
- $869
- Updated
- 2021/12/16
- Product number
- B-1371
- Product name
- HOOCCH2O-PEG3-CH2COOtBu
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $265.83
- Updated
- 2021/12/16
t-butyl acetate-PEG3-CH2COOH Chemical Properties,Usage,Production
Uses
t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity
t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
t-butyl acetate-PEG3-CH2COOH Preparation Products And Raw materials
Raw materials
Preparation Products
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