t-butyl acetate-PEG3-CH2COOH

Product Name: t-butyl acetate-PEG3-CH2COOH
CAS No.: 1442466-57-0
Chemical Name: t-butyl acetate-PEG3-CH2COOH
Synonyms: HOOCCH2O-PEG3-CH2COOtBu;COOtBu-CH2-PEG3-OCH2COOH;t-butyl acetate-PEG3-CH2COOH;16,16-Dimethyl-14-oxo-3,6,9,12,15-pentaoxaheptadecanoic acid;3,6,9,12-Tetraoxatetradecanedioic acid, 1-(1,1-dimethylethyl) ester;HOOCCH2O-PEG3-CH2COOtBu/3,6,9,12-Tetraoxatetradecanedioic acid, 1-(1,1-dimethylethyl) ester
CBNumber: CB73129062
Molecular Formula: C14H26O8
Formula Weight: 322.35
MOL File: 1442466-57-0.mol

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t-butyl acetate-PEG3-CH2COOH Property

Boiling point:: 435.6±35.0 °C(Predicted)
Density: 1.138±0.06 g/cm3(Predicted)
pka: 3.39±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS107830
Product name: HOOCCH2O-PEG3-CH2COOtBu
Purity: 97%
Packaging: 250mg
Price: $396
Updated: 2021/12/16

Activate Scientific

Product number: AS107830
Product name: HOOCCH2O-PEG3-CH2COOtBu
Purity: 97%
Packaging: 1g
Price: $869
Updated: 2021/12/16

Acrotein

Product number: B-1371
Product name: HOOCCH2O-PEG3-CH2COOtBu
Purity: 97%
Packaging: 0.25g
Price: $265.83
Updated: 2021/12/16

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t-butyl acetate-PEG3-CH2COOH Chemical Properties,Usage,Production

Uses

t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Biological Activity

t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

t-butyl acetate-PEG3-CH2COOH Preparation Products And Raw materials

Raw materials

Preparation Products

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t-butyl acetate-PEG3-CH2COOH Suppliers

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Bide Pharmatech Ltd.

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1442466-57-0, t-butyl acetate-PEG3-CH2COOHRelated Search:

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t-butyl acetate-PEG3-CH2COOH

HOOCCH2O-PEG3-CH2COOtBu

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3,6,9,12-Tetraoxatetradecanedioic acid, 1-(1,1-dimethylethyl) ester

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COOtBu-CH2-PEG3-OCH2COOH

1442466-57-0