PHOSPHATIDYLETHANOL

PHOSPHATIDYLETHANOL Property

storage temp. 

-20°

solubility 

Soluble in Chloroform (up to 10 mg/ml).

form 

Viscous oil / waxy solid

Stability:

Stable for 2 years from date of purchase as supplied. Phosphatidylethanol is subject to oxidation and must be protected from exposure to air. Solutions in chloroform may be stored at -20° for up to 3 months.

Hazard and Precautionary Statements (GHS)

PHOSPHATIDYLETHANOL Chemical Properties,Usage,Production

Description

Phosphatidlyethanol is an endogenous metabolite of phosphatidylcholine. Phospholipase D converts phosphatidylcholine to phosphatidylethanol in the presence of ethanol. This reaction is the basis of a sensitive and selective assay for PLD activity in intact cells for which this product may be used as a chromatographic standard.

References

[1] MUTSUHIRO KOBAYASHI  Julian N K. Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D[J]. Journal of Neurochemistry, 1987, 48 5: 1597-1603. DOI:10.1111/j.1471-4159.1987.tb05707.x
[2] LISCOVITCH M. Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C.[J]. The Journal of Biological Chemistry, 1989, 264 3: 1450-1456.
[3] J. PAI. Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.[J]. The Journal of Biological Chemistry, 1988, 16 1: 12472-12477. DOI:10.1016/s0021-9258(18)37778-0