2-(tert-Butylamino)sulfonylphenylboronic acid
- Product Name
- 2-(tert-Butylamino)sulfonylphenylboronic acid
- CAS No.
- 150691-04-6
- Chemical Name
- 2-(tert-Butylamino)sulfonylphenylboronic acid
- Synonyms
- AKOS BRN-0531;CHEMBRDG-BB 3200963;2-(tert-Butylsulfamoyl)phenylboronic Acid;2-(T-BUTYLAMINO)SULFONYLPHENYLBORONIC ACID;2-(TERT-BUTYLAMINO)SULFONYLPHENYLBORONIC ACID;N-TERT-BUTYLBENZENESULFONAMIDE-2-BORONIC ACID;(2-(N-(tert-Butyl)sulfamoyl)phenyl)boronic acid;(2-((TERT-BUTYLAMINO)SULFANYL)PHENYL) BORONIC ACID;[2-(tert-butylsulfamoyl)phenyl]boronic acid - [S20138];Boronic acid, B-[2-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-
- CBNumber
- CB0491873
- Molecular Formula
- C10H16BNO4S
- Formula Weight
- 257.11
- MOL File
- 150691-04-6.mol
2-(tert-Butylamino)sulfonylphenylboronic acid Property
- Melting point:
- 118-119 °C
- Boiling point:
- 443.2±55.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.00±0.53(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B694033
- Product name
- 2-(t-Butylamino)sulfonylphenylboronicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-W005892
- Product name
- (2-(N-(tert-Butyl)sulfamoyl)phenyl)boronicacid
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- X0536
- Product name
- 2-(t-Butylamino)sulfonylphenylboronicacid
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- FB147489
- Product name
- 2-(tert-Butylamino)sulfonylphenylboronicacid
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB147489
- Product name
- 2-(tert-Butylamino)sulfonylphenylboronicacid
- Packaging
- 500mg
- Price
- $115
- Updated
- 2021/12/16
2-(tert-Butylamino)sulfonylphenylboronic acid Chemical Properties,Usage,Production
Synthesis
2512-24-5
150691-04-6
A hexane solution (100 ml, 164 mmol) of 1.6 M n-butyllithium was added slowly and dropwise to an ice bath solution of N-tert-butylbenzenesulfonamide (15.92 g, 74.7 mmol) in N-tert-butylbenzenesulfonamide (200 ml) over 30 min. The reaction mixture was kept in a clarified state. Subsequently, triisopropyl borate (24.1 ml, 104 mmol) was added dropwise under ice bath conditions. The reaction mixture was stirred at room temperature for 3.5 h. The solution was observed to become gradually turbid. After completion of the reaction, the mixture was cooled in an ice bath and 1N hydrochloric acid (200 ml) was added slowly. The mixture was stirred at room temperature overnight. The reaction solution was extracted with ether (2 x 50 ml). The combined organic phases were washed with 1N sodium hydroxide (2 x 60 ml). The aqueous phase was adjusted to pH=1 with 6N hydrochloric acid and extracted again with ether (2×100 ml). The combined ether extracts were dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was recrystallized by a solvent mixture of ether and hexane to give 2-(tert-butylamino)sulfonylphenylboronic acid as a white solid (11.5 g, 60% yield). es-MS (M + H)+ = 258.
References
[1] Patent: US6673817, 2004, B1. Location in patent: Page column 200
[2] Patent: EP874629, 2004, B1. Location in patent: Page/Page column 15-16
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 22, p. 2947 - 2950
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 12, p. 1651 - 1655
[5] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 6841 - 6849
2-(tert-Butylamino)sulfonylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(tert-Butylamino)sulfonylphenylboronic acid manufacturers
- Product
- 2-(tert-Butylamino)sulfonylphenylboronic acid 150691-04-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-12