RIMEXOLONE (100 MG) Property

Melting point:

258-268 ºC

alpha 

D +100° (c = 0.92 in pyridine)

Boiling point:

507.0±50.0 °C(Predicted)

Density 

1.12

pka

14.42±0.70(Predicted)

InChIKey

QTTRZHGPGKRAFB-OOKHYKNYSA-N

Safety

HS Code 

2937290000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

RIMEXOLONE (100 MG) Chemical Properties,Usage,Production

Description

Rimexolone, an ophthalmic corticosteroid, was launched in 1995 in the U.S.A. for the treatment of postoperative inflammation following ocular surgery and anterior uveitis. Rimexolone has high corticoid receptor affinity and is a potent local antiinflammatory agent with minimal systemic effects and virtually no atrophogenic action in many animal models studied, unique among a wide range of topical steroids. Rapid onset, long duration of action plus a superior safety profile are characteristics of rimexolone. It was also approved in Europe for the treatment of rheumatoid arthritis and is currently in clinical trials for tendinitis and osteoarthritis.

Originator

Akzo (Netherlands)

Uses

Anti-inflammatory (local).

Definition

ChEBI: Rimexolone is a 20-oxo steroid.

brand name

Vexol (Alcon).

General Description

Rimexolone, 11β-hydroxy-16α,17α-dimethyl-17-(1-oxopropyl)androsta-1,4-diene-3-one,like medrysone and fluorometholone, lacks the C21 OHgroup. In addition, rimexolone has an additional methylgroup in the 17 -position, a site where an OH group is typicallyfound. Rimexolone is available as a suspension forophthalmic use.