GARCINOLIC ACID; TRANS-(SH)

GARCINOLIC ACID; TRANS-(SH) Property

Boiling point:

602.6±55.0 °C(Predicted)

Density 

1.055±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 30 mg/ml

form 

A film

pka

5.00±0.19(Predicted)

Safety

Hazard Codes 

T,N

Risk Statements 

25-50

Safety Statements 

61

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

GARCINOLIC ACID; TRANS-(SH) Chemical Properties,Usage,Production

Description

Garcinoic acid is a derivative of vitamin E originally isolated from C. grandiflora. It inhibits IL-1β-induced microsomal prostaglandin E₂ synthase-1 (mPGES-1) activity in A549 cells when used at concentrations of 1 and 10 μM. It has higher antioxidant activity relative to (±)-α-tocopherol in a cell-free assay when used at a concentration of 0.15 mM.

Uses

Garcinoic Acid displays anti-angiogenic activity as well as anti-oxidative activity in animals.

General Description

Natural product derived from plant source.

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] KHALED ALSABIL. Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.[J]. Planta medica, 2016, 82 11-12: 1110-1116. DOI: 10.1055/s-0042-108739
[3] KENJI TERASHIMA  Masatake N  Yoshiaki Takaya. Powerful antioxidative agents based on garcinoic acid from Garcinia kola[J]. Bioorganic & Medicinal Chemistry, 2002, 10 5: Pages 1619-1625. DOI: 10.1016/s0968-0896(01)00428-x