Astragaloside IV

ChemicalBook > CAS DataBase List > Astragaloside IV

Product Name: Astragaloside IV
CAS No.: 83207-58-3
Chemical Name: Astragaloside IV
Synonyms: Astragaloside IV;Astramembrannin i;Astragalin A;astragaloside A;Astragaloside IV;Astragaloside A 5%;ASTRAGALOSIDE IV(P);Astragaloside IV(A);Astragaloside IV CRS;Astragaloside IV ,98%
CBNumber: CB0500944
Molecular Formula: C41H68O14
Formula Weight: 784.97
MOL File: 83207-58-3.mol

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Astragaloside IV Property

Boiling point:: 895.7±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 12.91±0.70(Predicted)
InChI: InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24?,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/s3
InChIKey: QMNWISYXSJWHRY-APZLXCBQNA-N
SMILES: [C@@]123CC[C@]4(C)[C@]([H])([C@@H](O)C[C@@]4(C)[C@]1([H])C[C@H](O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)[C@@]1([H])C(C)(C)C(O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)CC[C@]21C3)[C@@]1(C)CC[C@@H](C(O)(C)C)O1 |&1:0,3,5,7,10,12,15,17,18,20,21,23,28,35,38,40,42,46,48,52,r|
LogP: 0.628 (est)
CAS DataBase Reference: 83207-58-3

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Safety

HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16677
Product name: Astragaloside A
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 16677
Product name: Astragaloside A
Purity: ≥98%
Packaging: 5mg
Price: $233
Updated: 2024/03/01

Cayman Chemical

Product number: 16677
Product name: Astragaloside A
Purity: ≥98%
Packaging: 10mg
Price: $412
Updated: 2024/03/01

Cayman Chemical

Product number: 16677
Product name: Astragaloside A
Purity: ≥98%
Packaging: 50mg
Price: $1092
Updated: 2024/03/01

TRC

Product number: A790125
Product name: AstragalosideA
Packaging: 1mg
Price: $45
Updated: 2021/12/16

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Astragaloside IV Chemical Properties,Usage,Production

Uses

Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

Definition

ChEBI: A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from <ital Astragalus membranaceus var mongholicus.

benefits

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.

Health effects

As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

Pharmaceutical Applications

Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

Mode of action

Astragaloside IV is a well-known AM compound known for its neuroprotective effects. It acts as an antioxidant and reduces cell inflammation and oxidative stress. Astragaloside IV helps protect dopaminergic neurons and promotes neural process outgrowth, potentially therapeutic in PD. All the benefits of this compound for neurodegenerative diseases such as AD, PD, cerebral ischemia, and autoimmune encephalomyelitis. AS-IV maintains dopamine synthesis by increasing enzymes tyrosine hydroxylase (TH) and nitric oxide synthase (NOS), which are involved in neuron production pathways, neural signalling, and cell immune responses. The other mechanism of AS-IV in PD disease is the prevention of neuron pathology by a neurotoxicant called 1-methyl-4-phenylpyridium ion (MPP+) throughout the increasing cell survival, inhibiting pro-apoptosis Bax-mediated pathway and caspase protein (Caspase-3) activity which can destroy cellular structures while increasing anti-apoptosis B-cell lymphoma 2 (Bcl-2). It also protects neuron mitochondria from apoptosis and DNA damage by inducing Akt to promote binding of hexokinase-II (HK-II) and mitochondria for the protection of neural mitochondria[1].

References

[1] Veit Ny . “Potential benefits of incorporating Astragalus membranaceus into the diet of people undergoing disease treatment: An overview.” Journal of Functional Foods 77 (2021): Article 104339.

Astragaloside IV Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Astragaloside IV manufacturers

Chengdu King-tiger Pharm-chem. Tech. Co., Ltd.

Product: Astragaloside IV 83207-58-3
Price: US $7.00-4600.00/g
Min. Order: 10g
Purity: 1%-98%
Supply Ability: 100
Release date: 2024-07-04

Hebei Kingfiner Technology Development Co.Ltd

Product: Astragaloside A 83207-58-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 50000kg
Release date: 2024-06-24

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Astragaloside a ;Astragaloside IV 83207-58-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-05-10

83207-58-3, Astragaloside IVRelated Search:

1,1,2,2-TETRAMETHYLCYCLOPROPANE Astragaloside VI AstragalosideⅠ Astragaloside IV,Astragaloside IV,ASTRAGALOSIDE CYCLOPENTADECANE 4-tert-Butylcyclohexanol Menthoxypropanediol CYCLOPENTADECANOL Astragalin Astragaloside II,Astragaloside B,Astragaloside-Ⅱ,ASTRAGALOSIDE II Astragaloside III,Astragaloside-Ⅲ ASTRAGALOSIDE I 2-METHYLPENTACOSANE 1,1-DIETHYLCYCLOPROPANE 2-(TRANS-4'-N-BUTYL-CYCLOHEXYL)PROPANE-1,3-DIOL 2-(TRANS-4-PENTYLCYCLOHEXYL)PROPANE-1,3-DIOL ASTRAGALOSIDE Astragaloside VII ASTRAGALOSIDE I(RG),Astragaloside Ⅳ

ASTRAGALOSIDE IV(P)

astragaloside A

Astragaloside IV

Astragaloside IV ,98%

Astragaloside IV(A)

Astragaloside A(Astragaloside IV)

Astramembrannin i

beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl

β-D-Glucopyranoside, (3β,6α,16β,24R)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl

Astragalus Extract Astragaloside IV

Astragaloside IV-Astragaloside A

Astragaloside IV CRS

Astragalin A

Astragaloside A USP/EP/BP

Astragaloside A 5%

b-D-Glucopyranoside, (3b,6a,16b,24R)-20,24-epoxy-16,25-dihydroxy-3-(b-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl

Astragaloside A (Astramembrannin I

astragalus polysaccharide concentrated extract

Astragalus methylside

(2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)hexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Astragaloside IV

83207-58-3

Inhibitors

API

Plant extracts