6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline
- Product Name
- 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline
- CAS No.
- 42835-89-2
- Chemical Name
- 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline
- Synonyms
- 6-Fluoro-1;4-tetrahydro-2-Methylquinoline;6-fluoro-tetrahydro-quinaldine;6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline;1,2,3,4-Tetrahydro-6-fluoro-2-Methylquinoline;2-Methyl-6-fluoro-1,2,3,4-tetrahydroquinoline;1,2,3,4-Tetrahydro-2-methyl-6-fluoroquinoline;Quinoline, 6-fluoro-1,2,3,4-tetrahydro-2-methyl-;6-FLUORO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE 99;6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 99%
- CBNumber
- CB0501118
- Molecular Formula
- C10H12FN
- Formula Weight
- 165.21
- MOL File
- 42835-89-2.mol
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline Property
- Melting point:
- 31-33°C
- Boiling point:
- 254.6±29.0 °C(Predicted)
- Density
- 1.0416 (estimate)
- Flash point:
- >110°C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 5.21±0.40(Predicted)
- color
- Off-White to Pale Yello
- optical activity
- 1.30°(C=0.01g/ml CHCL3)
- CAS DataBase Reference
- 42835-89-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- P000145114
- Product name
- 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
- Purity
- 98%
- Packaging
- 250mg
- Price
- $33
- Updated
- 2021/12/16
- Product number
- PC4146
- Product name
- 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- P000145114
- Product name
- 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 3H31-3-X7
- Product name
- 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- Q055
- Product name
- 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline
- Packaging
- 1g
- Price
- $135
- Updated
- 2021/12/16
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline Chemical Properties,Usage,Production
Chemical Properties
white to yellowish crystalline low melting solid
Uses
Intermediate in the production of anti-cancer quinoline derivatives and antibacterial agents
Synthesis
1128-61-6
42835-89-2
General procedure for the synthesis of 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline from 6-fluoro-2-methylquinoline: in a round-bottomed flask, pre-dried in an oven, a magnetic stirrer was added, followed by the sequential addition of 6-fluoro-2-methylquinoline (0.1 mmol), PCCP (1 mol%), Hantzsch dihydropyridine (3.0 equiv), and CHCl3 (2 mL). The reaction mixture was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent of hexane/EtOAc (20:1, v/v) to afford the target product 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline.
References
[1] Synlett, 2008, # 6, p. 900 - 902
[2] Tetrahedron Letters, 2017, vol. 58, # 21, p. 2050 - 2053
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 11, p. 1183 - 1187
[4] Chemistry - A European Journal, 2015, vol. 21, # 14, p. 5370 - 5379
[5] Journal of the American Chemical Society, 2015, vol. 137, # 36, p. 11718 - 11724
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline Suppliers
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View Lastest Price from 6-Fluoro-1,2,3,4-tetrahydro-2-methylquinoline manufacturers
- Product
- 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 42835-89-2
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-24