PF429242 dihydrochloride
- Product Name
- PF429242 dihydrochloride
- CAS No.
- 2248666-66-0
- Chemical Name
- PF429242 dihydrochloride
- Synonyms
- PF429242 2HCl;PF 429242-HCl;PF429242 dihydrochloride, 10 mM in DMSO;PF429242,PF-429242 dihydrochloride,PF429242 dihydrochloride,Virus Protease,inhibit,PF 429242,Inhibitor,Fatty Acid Synthase (FASN),PF-429242
- CBNumber
- CB05419810
- Molecular Formula
- C25H36ClN3O2
- Formula Weight
- 446.03
- MOL File
- 2248666-66-0.mol
PF429242 dihydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- White to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H303May be harmfulif swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15140
- Product name
- PF-429242 (hydrochloride)
- Packaging
- 1mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 15140
- Product name
- PF-429242 (hydrochloride)
- Packaging
- 25mg
- Price
- $547
- Updated
- 2024/03/01
- Product number
- 15140
- Product name
- PF-429242 (hydrochloride)
- Packaging
- 5mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 15140
- Product name
- PF-429242 (hydrochloride)
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- CS-6890
- Product name
- PF-429242 dihydrochloride
- Purity
- 98.08%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2021/12/16
PF429242 dihydrochloride Chemical Properties,Usage,Production
Description
PF-429242 is an inhibitor of site-1 protease with an IC50 value of 170 nM for human recombinant site-1 protease. It is selective for site-1 protease over trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, and furin at concentrations up to 100 μM. PF-429242 completely inhibits proteolytic processing and nuclear translocation of sterol regulatory element-binding protein (SREBP) in HepG2 cells at a concentration of 10 μM. It also reduces expression of HMG-CoA synthase and fatty acid synthase (EC50s = 0.3 and 2 μM, respectively) and inhibits cholesterol synthesis (EC50 = 600 nM) in HepG2 cells and reduces cholesterol and fatty acid synthesis in CD-1 mice. PF-429242 inhibits replication of dengue virus serotypes 1-4 in infected HeLa cells. It also reduces growth of T98G, U87-MG, and A172 glioblastoma cells (IC50s = 0.32, 15.2, and 27.6 μM, respectively).
Uses
PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1].
in vivo
In mice treated with PF-429242 for 24 h, the expression of hepatic SREBP target genes is suppressed, and the hepatic rates of cholesterol and fatty acid synthesis are reduced[1].
storage
Desiccate at RT
References
[1] Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol DOI:10.1124/jpet.108.139626
[2] Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8(2). pii: E46. doi: 10.3390/v8020046. DOI:10.3390/v8020046
[3] Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85(2):795-803. DOI:10.1128/JVI.02019-10
PF429242 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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