BTdCPU
- Product Name
- BTdCPU
- CAS No.
- 1257423-87-2
- Chemical Name
- BTdCPU
- Synonyms
- BTdCPU;BTdCPU, 10 mM in DMSO;eIF2–GTP–tRNAiMetTernaryCompInhib, BTdCPU;Inhibitor,BTdCPU,Phosphatase,inhibit,Apoptosis;Urea, N-1,2,3-benzothiadiazol-6-yl-N'-(3,4-dichlorophenyl)-;1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
- CBNumber
- CB05476529
- Molecular Formula
- C13H8Cl2N4OS
- Formula Weight
- 339.2
- MOL File
- 1257423-87-2.mol
BTdCPU Property
- Density
- 1.664±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥ 250 mg/mL (737.03 mM)
- pka
- 11.75±0.43(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0065564
- Product name
- BTdCPU
- Purity
- 99.48%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0065564
- Product name
- BTdCPU
- Purity
- 99.48%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0065564
- Product name
- BTdCPU
- Purity
- 99.48%
- Packaging
- 25mg
- Price
- $990
- Updated
- 2021/12/16
- Product number
- CS-0065564
- Product name
- BTdCPU
- Purity
- 99.48%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0065564
- Product name
- BTdCPU
- Purity
- 99.48%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
BTdCPU Chemical Properties,Usage,Production
Uses
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone.html" class="link-product" target="_blank">Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2].
in vivo
BTdCPU (175 mg/kg; i.p.; single daily for 21 days) inhibits tumor growth without toxicity in mice xenograft breast tumors model[2].
| Animal Model: | Female nude mice (mice xenograft breast tumors model)[2]. |
| Dosage: | 175 mg/kg |
| Administration: | Intraperitoneal injection; single daily for 21 days |
| Result: | Led to complete tumor stasis,which persisted for the remainder of the 3-week study Showed good safety in mice. |
References
[1] Burwick N, et al. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 Apr;55:23-32. DOI:10.1016/j.leukres.2017.01.007
[2] Chen T, et al. Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Jul 17;7(9):610-6. DOI:10.1038/nchembio.613
BTdCPU Preparation Products And Raw materials
Raw materials
Preparation Products
BTdCPU Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
View Lastest Price from BTdCPU manufacturers
- Product
- BTdCPU 1257423-87-2
- Price
- US $110.00-1050.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-28