ChemicalBook > CAS DataBase List > 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-

2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-

Product Name
2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-
CAS No.
187325-53-7
Chemical Name
2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-
Synonyms
GSK-3β inhibitor 1;(Z)-3-(Pyridin-2-ylmethylene)indolin-2-one;(3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-;GSK-3,inhibit,Glycogen synthase kinase 3,Glycogen synthase kinase-3,GSK3β inhibitor 1,GSK-3β inhibitor 1,Inhibitor,GSK 3β inhibitor 1
CBNumber
CB05482665
Molecular Formula
C14H10N2O
Formula Weight
222.24
MOL File
187325-53-7.mol
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2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Property

Boiling point:
457.2±45.0 °C(Predicted)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
12.34±0.20(Predicted)
form 
Solid
color 
Yellow to orange
InChI
InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
InChIKey
YKQONSWBHGBDSB-XFXZXTDPSA-N
SMILES
N1C2=C(C=CC=C2)/C(=C/C2=NC=CC=C2)/C1=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0090785
Product name
GSK-3βinhibitor1
Purity
98.07%
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0090785
Product name
GSK-3βinhibitor1
Purity
98.07%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0090785
Product name
GSK-3βinhibitor1
Purity
98.07%
Packaging
50mg
Price
$950
Updated
2021/12/16
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2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Chemical Properties,Usage,Production

Uses

GSK-3β inhibitor 1 (compound 3a) inhibits GSK-3β with an IC50 of 4.19 nM. GSK-3β inhibitor 1 demonstrates high antidiabetic efficacy in obese Streptozotocin (HY-13753)-treated rats[1].

in vivo

GSK-3β inhibitor 1 (50 mg/kg, i.p., 30 min prior to glucose challenge) effectively prevents increase in blood glucose levels in HFD+STZ diabetic rats[1].

Animal Model:HFD+STZ diabetic rats [1] .
Dosage:50 mg/kg
Administration: i.p., 30 min prior to glucose challenge
Result:Vehicle-treated diabetic rats developed persistent hyperglycemic response. Administration of GSK-3β inhibitor 1 30 min prior to glucose challenge effectively prevented increase in blood glucose levels.

IC 50

GSK-3β: 4.9 nM (IC50)

References

[1] Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817. DOI:10.1016/j.bmc.2019.03.028

2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- Suppliers

China 37 United States 4 Global 41
Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.
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Shanghai Rechem science Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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Amel Pharmatech Corporation
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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187325-53-7, 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-Related Search:


  • 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-
  • GSK-3β inhibitor 1
  • GSK-3,inhibit,Glycogen synthase kinase 3,Glycogen synthase kinase-3,GSK3β inhibitor 1,GSK-3β inhibitor 1,Inhibitor,GSK 3β inhibitor 1
  • (Z)-3-(Pyridin-2-ylmethylene)indolin-2-one
  • (3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one
  • 187325-53-7