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EGFR-IN-7 (compound 34)

Product Name
EGFR-IN-7 (compound 34)
CAS No.
2267329-76-8
Chemical Name
EGFR-IN-7 (compound 34)
Synonyms
TQB3804;TBQ3804;EGFR-IN-7;EGFR Inhibitor 2;Egfr-IN-7(TQB3804 );TQB-3804 (EGFR-IN-7);EGFR-IN-7 (COMPOUND 34);TQB3804 (EGFR-IN-7) ，S6698;TQB 3804 EGFR-IN-7 (compound 34);HER1,EGFR IN 7,ErbB-1,EGFR,Inhibitor,inhibit,Epidermal growth factor receptor,EGFRIN7
CBNumber
CB05540385
Molecular Formula
C32H41BrN9O2P
Formula Weight
694.6
MOL File
2267329-76-8.mol
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EGFR-IN-7 (compound 34) Property

Boiling point:
858.7±75.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 5 mg/mL (7.20 mM; ultrasonic and warming and adjust pH to 5 with 0.1 M HCL and heat to 60°C)
pka
8.14±0.42(Predicted)
form 
Solid
color 
Light yellow to yellow
InChIKey
ZYSKXRAGBGLELB-UHFFFAOYSA-N
SMILES
C1(NC2=CC(C)=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)=NC=C(Br)C(NC2=CC=C3C(=C2P(C)(C)=O)N=CC=N3)=N1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0101441
Product name
EGFR-IN-7
Purity
99.76%
Packaging
5mg
Price
$295
Updated
2021/12/16
ChemScene
Product number
CS-0101441
Product name
EGFR-IN-7
Purity
99.76%
Packaging
10mg
Price
$495
Updated
2021/12/16
ChemScene
Product number
CS-0101441
Product name
EGFR-IN-7
Purity
99.76%
Packaging
50mg
Price
$1300
Updated
2021/12/16
DC Chemicals
Product number
020460
Product name
Egfr-IN-7(TQB3804)
Packaging
002
Price
$1700
Updated
2021/12/16
DC Chemicals
Product number
020460
Product name
Egfr-IN-7(TQB3804)
Packaging
003
Price
$3400
Updated
2021/12/16
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EGFR-IN-7 (compound 34) Chemical Properties,Usage,Production

Uses

EGFR-IN-7 is a potent, selective and orally active EGFR kinase inhibitor. EGFR-IN-7 has inhibitory effect for for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) with IC50 values of 7.92 nM and 0.218 nM, respectively. EGFR-IN-7 can be used for the research of various cancers[1].

in vivo

EGFR-IN-7 (compound 34; 5-45 mg/kg; p.o.; daily; for 13 days) shows potent anti-tumor activity in a subcutaneously implanted Ba/F 3 (Δ19del/T790M/C797S)-derived xenograft (CDX) BALB/c nude mouse resistance model[1].
EGFR-IN-7 (25 and 50 mg/kg; p.o.; daily, for 3 weeks) has a significant inhibitory effect on tumor growth in the mouse subcutaneous xenograft PC-9 (Δ19del) model[1].

Animal Model:Ba/F 3 (Δ19del/T790M/C797S)-derived xenograft (CDX) BALB/c nude mice (female, 6-8 weeks, 18-22 g)[1]
Dosage:5, 15, 45 mg/kg
Administration:Oral administration, daily, for 13 days
Result:Significantly increased the half-life, the amount of exposure in plasma and tissues, had good pharmacokinetic effects in mice.
Animal Model:Subcutaneous xenograft PC-9 (Δ19del) model[1]
Dosage:0-9 days: 50 mg/kg, 10-21 days: 25 mg/kg
Administration:Oral administration, once a day, 3 weeks
Result:Had a significant inhibitory effect on tumor growth, had a tumor-reducing effect and showed good antitumor efficacy.

IC 50

EGFR (WT): 7.92 nM (IC50); EGFR (C797S/T790M/L858R): 0.218 nM (IC50)

References

[1] Ling WY, et, al. Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase. WO2019015655A1.

EGFR-IN-7 (compound 34) Preparation Products And Raw materials

Raw materials

Preparation Products

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EGFR-IN-7 (compound 34) Suppliers

China 73 United States 4 Global 77
RuiKeXin
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19938953786
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China
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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info@chemlin.com.cn
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China
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Shanghai Topbiochem Technology Co., Ltd
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021-58170097
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Shanghai Jian Chao Chemical Technology Co., Ltd.
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150-2103-5486 18017383231
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qq：2817624287
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SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
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13816107857
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qq: 276312098
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sales@fortunechem-sh.com
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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ChemStrong Scientific Co.,Ltd
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Twochem Co.Ltd
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021-021-58111628 15800915896
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QQ 3285589261
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2267329-76-8, EGFR-IN-7 (compound 34)Related Search:


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  • TQB-3804 (EGFR-IN-7)
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  • HER1,EGFR IN 7,ErbB-1,EGFR,Inhibitor,inhibit,Epidermal growth factor receptor,EGFRIN7
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  • TQB3804 (EGFR-IN-7) ，S6698
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  • C32H41BrN9O2P