MIK-8719
- Product Name
- MIK-8719
- CAS No.
- 1382799-40-7
- Chemical Name
- MIK-8719
- Synonyms
- MK-8719;MIK-8719;MK-8719 ，S8890;MK-8719, 10 mM in DMSO;MK 8719,inhibit,MK-8719,MK8719,Inhibitor;(3aR,5S,6S,7R,7aR)-5-(Difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol;5H-Pyrano[3,2-d]thiazole-6,7-diol, 5-(difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-, (3aR,5S,6S,7R,7aR)-
- CBNumber
- CB05581733
- Molecular Formula
- C9H14F2N2O3S
- Formula Weight
- 268.28
- MOL File
- 1382799-40-7.mol
MIK-8719 Property
- Boiling point:
- 431.4±55.0 °C(Predicted)
- Density
- 1.78±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (372.74 mM; Need ultrasonic)
- pka
- 12.72±0.70(Predicted)
- form
- Solid
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
MIK-8719 Chemical Properties,Usage,Production
Uses
MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].
in vivo
MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response[1].
References
[1] Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29. DOI:10.1021/acs.jmedchem.9b01090
MIK-8719 Preparation Products And Raw materials
Raw materials
Preparation Products
MIK-8719 Suppliers
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
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- 4817
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- 177-54423994 17754423994
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- QQ:2853530913
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- China
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- 0550-5196001 15000891977
- Fax
- 0550-5196001
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- China
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- 1946
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
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- United States
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- +1-2135480471 +1-2135480471;
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- 15869524721
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- China
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- 18051384581
- sales@chemhifuture.com
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- China
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- 13000000000
- Fax
- jinoupharma@163
- jinoupharma@163.com
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- China
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- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
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- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
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View Lastest Price from MIK-8719 manufacturers
- Product
- MIK-8719 1382799-40-7
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-18