Hazard and Precautionary Statements (GHS)

PIVMECILLINAM HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Pivmecillinam is an orally active prodrug of Amdinocillin (A576300), an broad spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2.

Clinical Use

Antibacterial agent

Drug interactions

Potentially hazardous interactions with other drugs
Antiepileptics: avoid concomitant use with valproate.
Methotrexate: penicillins can reduce the excretion of methotrexate (increased risk of toxicity).
Probenecid: reduces excretion of penicillins.

Metabolism

Pivmecillinam is rapidly hydrolysed to mecillinam which is the active drug, plus pivalic acid and formaldehyde. About 45% of a dose may be excreted in the urine as mecillinam, mainly within the first 6 hours. Mecillinam is partly excreted with bile, giving rise to biliary concentrations about 3 times the serum levels.