ChemicalBook > CAS DataBase List > MAC-545496

MAC-545496

Product Name
MAC-545496
CAS No.
838810-96-1
Chemical Name
MAC-545496
Synonyms
MAC-545496;MAC-545496, 10 mM in DMSO;N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide;N-[[(5-Chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide;Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-;Bacterial,S. aureus,Antivirulence,Inhibitor,MAC545496,mprF,nanomolar,GraR,MAC-545496,MRSA,survival,inhibit,biofilm,MAC 545496,virulence,β-lactam
CBNumber
CB06124311
Molecular Formula
C18H18ClN5O3S
Formula Weight
419.89
MOL File
838810-96-1.mol
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MAC-545496 Property

Density 
1.458±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (25 mg/ml)
form 
solid
pka
7.09±0.70(Predicted)
color 
Yellow/orange
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0109477
Product name
MAC-545496
Purity
99.72%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0109477
Product name
MAC-545496
Purity
99.72%
Packaging
10mg
Price
$160
Updated
2021/12/16
Adipogen Life Sciences
Product number
AG-CR1-0163-M005
Product name
MAC-545496
Purity
≥98%(HPLC)
Packaging
5mg
Price
$210
Updated
2021/12/16
ChemScene
Product number
CS-0109477
Product name
MAC-545496
Purity
99.72%
Packaging
50mg
Price
$450
Updated
2021/12/16
Ambeed
Product number
A1263957
Product name
N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide
Purity
98%
Packaging
5mg
Price
$80
Updated
2021/12/16
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MAC-545496 Chemical Properties,Usage,Production

Description

MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR).? GraR and its regulatory system are important for virulence of S. aureus.? MAC-545496 is able to reverse ?-lactam resistance in S. aureus in a G. Mellonella larvae model.? 0.06 μg/mL MAC-545496? lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ?-lactam MIC from 512 to 8 μg/mL against S. aureus USA300.

References

El-Halfawy et al. (2020), Discovery of an antivirulence compound that reverses ?-lactam resistance in MRSA; Nat. Chem. Biol., 16 143

MAC-545496 Preparation Products And Raw materials

Raw materials

Preparation Products

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MAC-545496 Suppliers

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838810-96-1, MAC-545496Related Search:

RESINIFERATOXIN Ibrutinib Volasertib (BI 6727) NORFLUOXETINE HYDROCHLORIDE

  • MAC-545496
  • Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-
  • N-[[(5-Chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide
  • Bacterial,S. aureus,Antivirulence,Inhibitor,MAC545496,mprF,nanomolar,GraR,MAC-545496,MRSA,survival,inhibit,biofilm,MAC 545496,virulence,β-lactam
  • N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide
  • MAC-545496, 10 mM in DMSO
  • 838810-96-1