TOPOTECAN-D6

Product Name: TOPOTECAN-D6
CAS No.: 1044904-10-0
Chemical Name: TOPOTECAN-D6
Synonyms: Hycamtin-d6;TOPOTECAN-D6;NSC-609669-d6;SKF-104864A-d6;[2H6]-Topotecan;Topotecan dihydrochloride salt;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CBNumber: CB0649948
Molecular Formula: C23H23N3O5
Formula Weight: 421.45
MOL File: 1044904-10-0.mol

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TOPOTECAN-D6 Property

Melting point:: 213-218°C (dec)
storage temp.: -20°C Freezer
solubility: aqueous acid: soluble; DMSO: slightly; Methanol: soluble
form: A solid
Stability:: Hygroscopic
CAS DataBase Reference: 1044904-10-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29082
Product name: Topotecan-d6
Packaging: 500μg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 29082
Product name: Topotecan-d6
Packaging: 1mg
Price: $299
Updated: 2024/03/01

Usbiological

Product number: T8067-11
Product name: Topotecan-d6
Packaging: 1mg
Price: $460
Updated: 2021/12/16

TRC

Product number: T542502
Product name: Topotecan-d6
Packaging: 10mg
Price: $1455
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0005320
Product name: TOPOTECAN-D6
Purity: 95.00%
Packaging: 100MG
Price: $1871.1
Updated: 2021/12/16

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TOPOTECAN-D6 Chemical Properties,Usage,Production

Description

Topotecan-d₆ is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC₅₀ values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC₅₀s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.

Chemical Properties

Light Yellow to Greenish Powder

Uses

Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic

Uses

Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.

TOPOTECAN-D6 Preparation Products And Raw materials

Raw materials

Preparation Products

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TOPOTECAN-D6 Suppliers

Canada 2 China 17 France 1 India 1 United States 4 Global 25

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9293
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55827
Advantage: 58

Hefei Molake Biotechnology Co., Ltd.

Tel: 0551-66336380 18956014586
Fax: 055166336380
Email: 983438788@qq.com
Country: China
ProdList: 2077
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shanghai Ruipu Medical Technology Co., Ltd

Tel: 15895968936
Fax: qq 1018762393
Email: 1018762393@qq.com
Country: China
ProdList: 9862
Advantage: 58

1044904-10-0, TOPOTECAN-D6Related Search:

Topotecan Carboxylic Acid Sodium Salt Topotecan

TOPOTECAN-D6

(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

SKF-104864A-d6

(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Hycamtin-d6

NSC-609669-d6

(4S)-10-[[Di(methyl-d<sub>3</sub>)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

[2H6]-Topotecan

Topotecan dihydrochloride salt

1044904-10-0

C23H17D6N3O5

C23H17N3O5D6

Heterocycles

Isotope Labelled Compounds

Inhibitors

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Pharmaceuticals