ChemicalBook > CAS DataBase List > 5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER

5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER

Product Name
5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER
CAS No.
1073354-99-0
Chemical Name
5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER
Synonyms
5-AMINOPYRIDINE-3-BORONIC ACID, PICOL ESTER;5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-;3-AMinopyridin-5-ylboronic acid pinacol ester;5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER;(5-AMINOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;5-aminopyridine-3-borate frequency which ol ester;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine;5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinaMine;3-PYRIDINAMINE, 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-;5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER ISO 9001：2015 REACH
CBNumber
CB0651172
Molecular Formula
C11H17BN2O2
Formula Weight
220.08
MOL File
1073354-99-0.mol
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5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER Property

Boiling point:
388.5±27.0 °C(Predicted)
Density 
1.09
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form 
solid
pka
6.16±0.22(Predicted)
color 
brown
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Safety

Hazard Codes 
C,T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Hazard Note 
Corrosive
TSCA 
No
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BML00184
Product name
3-Aminopyridine-5-boronic acid pinacol ester
Purity
Aldrich
Packaging
1g
Price
$185
Updated
2025/07/31
TRC
Product number
A629033
Product name
3-Aminopyridine-5-boronic acid pinacol ester
Packaging
1g
Price
$100
Updated
2021/12/16
TRC
Product number
A629033
Product name
3-Aminopyridine-5-boronic acid pinacol ester
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
A629033
Product name
3-Aminopyridine-5-boronic acid pinacol ester
Packaging
250mg
Price
$50
Updated
2021/12/16
Apolloscientific
Product number
OR3184
Product name
5-Aminopyridine-3-boronic acid, pinacol ester
Packaging
1g
Price
$57
Updated
2021/12/16
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5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production

Synthesis

15862-30-3

73183-34-3

1073354-99-0

Under nitrogen atmosphere, 3-bromo-5-nitropyridine (20.3 g, 0.10 mol), pinacol ester of bisboronic acid (25.4 g, 0.10 mol), potassium acetate (14.7 g, 0.15 mol), and catalyst PdCl2 (dppf) (0.74 g, 0.001 mol) were sequentially added to 550 mL of dioxane and stirred well. The reaction system was slowly warmed up to 80-90 °C and the reaction was kept stirring for 2-3 hours. After monitoring the completion of the reaction by GC, the reaction mixture was cooled and filtered through diatomaceous earth to obtain a dark black filtrate. The filtrate was allowed to react at room temperature with stirring overnight under a hydrogen atmosphere at 1 atmosphere. At the end of the reaction, activated charcoal was added for decolorization, followed by distillation under reduced pressure to remove the solvent until no fraction escaped. Heptane mixed solvent was added to the residue, which was cooled and pulped for 30 min and filtered to obtain a light gray crude product. The crude product was dissolved by heating with ethanol, and crystals were precipitated after cooling, the filter cake was washed with anhydrous ethanol at -20°C, and after drying, 15.6g of 5-aminopyridine-3-boronic acid pinacol ester was obtained as a light yellow solid with a yield of 71% and a purity of 97.9% by HPLC.

References

[1] Patent: CN108047258, 2018, A. Location in patent: Paragraph 0005; 0014; 0015

5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER Suppliers

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View Lastest Price from 5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER 1073354-99-0
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Career Henan Chemical Co
Product
5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER 1073354-99-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGs
Release date
2019-12-19

1073354-99-0, 5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTERRelated Search:

Indole-4-boronic acid pinacol ester 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER 5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER 3-TERT-BUTYLOXYCARBONYLAMINO-2-FLUOROPYRIDINE-5-BORONIC ACID PINACOL ESTER 3-TERT-BUTYLOXYCARBONYLAMINO-2-CHLOROPYRIDINE-5-BORONIC ACID PINACOL ESTER 2-CHLORO-5-NITROPYRIDINE-3-BORONIC ACID PINACOL ESTER 2-TERT-BUTYLOXYCARBONYLAMINO-3-NITROPYRIDINE-5-BORONIC ACID PINACOL ESTER 2-CHLORO-3-NITROPYRIDINE-5-BORONIC ACID PINACOL ESTER 2-TERT-BUTYLOXYCARBONYLAMINO-5-NITROPYRIDINE-3-BORONIC ACID PINACOL ESTER 5-TERT-BUTYLOXYCARBONYLAMINO-2-CHLOROPYRIDINE-3-BORONIC ACID PINACOL ESTER 2-CHLORO-4-METHYL-3-NITROPYRIDINE-5-BORONIC ACID PINACOL ESTER 3-AMINO-2-CHLOROPYRIDINE-5-BORONIC ACID, PINACOL ESTER 2-METHOXY-5-NITROPYRIDINE-3-BORONIC ACID PINACOL ESTER 5-TERT-BUTYLOXYCARBONYLAMINO-2-METHOXYPYRIDINE-3-BORONIC ACID PINACOL ESTER 1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)piperazine 2-TERT-BUTYLOXYCARBONYLAMINO-4-METHYL-3-NITROPYRIDINE-5-BORONIC ACID PINACOL ESTER 2-METHOXY-4-METHYL-3-NITROPYRIDINE-5-BORONIC ACID PINACOL ESTER 2,3-Diaminopyridine-5-boronic acid, pinacol ester

  • 5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER
  • 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan- 2-yl)-pyridin-3-ylamine
  • 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine
  • 3-AMinopyridin-5-ylboronic acid pinacol ester
  • 3-PYRIDINAMINE, 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
  • 5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinaMine
  • 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-
  • 5-AMINOPYRIDINE-3-BORONIC ACID, PICOL ESTER
  • (5-AMINOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER
  • 5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER ISO 9001：2015 REACH
  • 5-aminopyridine-3-borate frequency which ol ester
  • 1073354-99-0
  • 1073364-99-0
  • C11H19BN2O3