2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER
- Product Name
- 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER
- CAS No.
- 741709-63-7
- Chemical Name
- 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER
- Synonyms
- 16 2-cyano pyridine -5-boronic acid;2-CYANOPYRIDINE-5-BORONIC ACID PICOL ESTER;2-Cyanopyridine-5-boronic acid pinacol este;6-Cyano-3-pyridylboronic Acid Pinacol Ester;2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER;6-Cyanopyridine-3-boronic acid pinacol ester;(2-Cyanopyridin-5-yl)boronic acid pinacol ester;(6-CYANOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;2-(6-Cyano-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile
- CBNumber
- CB2376918
- Molecular Formula
- C12H15BN2O2
- Formula Weight
- 230.07
- MOL File
- 741709-63-7.mol
2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER Property
- Melting point:
- 105-106℃
- Boiling point:
- 370.7±27.0 °C(Predicted)
- Density
- 1.10
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- -0.33±0.12(Predicted)
- color
- White to Light yellow to Light orange
- Water Solubility
- Slightly soluble in water.
- CAS DataBase Reference
- 741709-63-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3126
- Product name
- 2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(T)
- Packaging
- 200mg
- Price
- $37
- Updated
- 2025/07/31
- Product number
- C3126
- Product name
- 2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $126
- Updated
- 2025/07/31
- Product number
- 269117
- Product name
- 2-Cyanopyridine-5-boronic acid pinacol ester
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- C987758
- Product name
- 2-Cyanopyridine-5-boronicacidpinacolester
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C987758
- Product name
- 2-Cyanopyridine-5-boronicacidpinacolester
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is used in suzuki reactions.
Synthesis
97483-77-7
73183-34-3
741709-63-7
To a 250 mL round bottom flask was added 5-bromo-2-cyanopyridine (3.0 g, 16.39 mmol), bis(pinacolato)diboron (4.58 g, 18.03 mmol), potassium acetate (5.47 g, 55.74 mmol), and dimethyl sulfoxide (100 mL). After degassing for 20 min, [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride dichloromethane complex (1.39 g, 1.64 mmol) was added. The reaction mixture was stirred at 80 °C for 24 h, followed by continued stirring at room temperature for 3 days. Upon completion of the reaction, 50 mL of water was added and the product was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The dark residue was purified by fast column chromatography (eluent: 20% acetone/hexane) to give a red solid. The solid was ground with hexane to give 1.72 g (46% yield) of the target product 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyanopyridine as a light pink solid.
References
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 13, p. 5473 - 5494
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1277 - 1281
[3] Patent: US2009/136473, 2009, A1. Location in patent: Page/Page column 36; 61
[4] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0438; 0449-0450
[5] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 70
2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
View Lastest Price from 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER manufacturers
- Product
- 2-Cyanopyridine-5-boronic acid pinacol ester 741709-63-7
- Price
- US $1.60-9.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
- Product
- 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER 741709-63-7
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12