ChemicalBook > CAS DataBase List > 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER

2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER

Product Name: 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER
CAS No.: 741709-63-7
Chemical Name: 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER
Synonyms: 16 2-cyano pyridine -5-boronic acid;2-CYANOPYRIDINE-5-BORONIC ACID PICOL ESTER;2-Cyanopyridine-5-boronic acid pinacol este;6-Cyano-3-pyridylboronic Acid Pinacol Ester;2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER;6-Cyanopyridine-3-boronic acid pinacol ester;(2-Cyanopyridin-5-yl)boronic acid pinacol ester;(6-CYANOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;2-(6-Cyano-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile
CBNumber: CB2376918
Molecular Formula: C12H15BN2O2
Formula Weight: 230.07
MOL File: 741709-63-7.mol

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2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER Property

Melting point:: 105-106℃
Boiling point:: 370.7±27.0 °C(Predicted)
Density: 1.10
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -0.33±0.12(Predicted)
color: White to Light yellow to Light orange
Water Solubility: Slightly soluble in water.
CAS DataBase Reference: 741709-63-7

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3126
Product name: 2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: >98.0%(T)
Packaging: 200mg
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: C3126
Product name: 2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: >98.0%(T)
Packaging: 1g
Price: $126
Updated: 2025/07/31

Usbiological

Product number: 269117
Product name: 2-Cyanopyridine-5-boronic acid pinacol ester
Packaging: 500mg
Price: $333
Updated: 2021/12/16

TRC

Product number: C987758
Product name: 2-Cyanopyridine-5-boronicacidpinacolester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C987758
Product name: 2-Cyanopyridine-5-boronicacidpinacolester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is used in suzuki reactions.

Synthesis

97483-77-7

73183-34-3

741709-63-7

To a 250 mL round bottom flask was added 5-bromo-2-cyanopyridine (3.0 g, 16.39 mmol), bis(pinacolato)diboron (4.58 g, 18.03 mmol), potassium acetate (5.47 g, 55.74 mmol), and dimethyl sulfoxide (100 mL). After degassing for 20 min, [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride dichloromethane complex (1.39 g, 1.64 mmol) was added. The reaction mixture was stirred at 80 °C for 24 h, followed by continued stirring at room temperature for 3 days. Upon completion of the reaction, 50 mL of water was added and the product was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The dark residue was purified by fast column chromatography (eluent: 20% acetone/hexane) to give a red solid. The solid was ground with hexane to give 1.72 g (46% yield) of the target product 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyanopyridine as a light pink solid.

References

[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 13, p. 5473 - 5494
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1277 - 1281
[3] Patent: US2009/136473, 2009, A1. Location in patent: Page/Page column 36; 61
[4] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0438; 0449-0450
[5] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 70

2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Cyanopyridine-5-boronic acid pinacol ester 741709-63-7
Price: US $1.60-9.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-20

Career Henan Chemical Co

Product: 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER 741709-63-7
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-12

741709-63-7, 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTERRelated Search:

(2-sulfanylphenyl)boronic acid 2-chloro-5-cyanopyridine Pyridine 3-Pyridylboronic acid 2-Aminopyridine-5-boronic acid, pinacol ester Indole-4-boronic acid pinacol ester 5-AMINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER Pinacol 2-Chloro-3-cyanopyridine-4-boronic Acid Pinacol Ester 3-Cyanopyridine-4-boronic acid pinacol ester, tech. 90% 2-CYANOPYRIDINE-3-BORONIC ACID, PINACOL ESTER 4-CYANOPYRIDINE-3-BORONIC ACID, PINACOL ESTER,4-Cyanopyridine-3-boronic acid pinacol ester, tech. 90% 4-CYANOPYRIDINE-2-BORONIC ACID PINACOL ESTER 3-CYANOPYRIDINE-2-BORONIC ACID PINACOL ESTER 6-CYANOPYRIDINE-2-BORONIC ACID PINACOL ESTER 5-CYANOPYRIDINE-2-BORONIC ACID PINACOL ESTER 2-CYANOPYRIDINE-4-BORONIC ACID PINACOL ESTER 3-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER

5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile, 95+%

2-CYANOPYRIDINE-5-BORONIC ACID PICOL ESTER

(2-Cyanopyridin-5-yl)boronic acid pinacol ester

2-Cyanopyridine-5-boronic acid pinacol este

5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile

2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carbonitrile

2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER

(6-CYANOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile

5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE-2-CARBONITRILE

16 2-cyano pyridine -5-boronic acid

6-Cyanopyridine-3-boronic acid pinacol ester

2-Pyridinecarbonitrile, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-(6-Cyano-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

6-Cyano-3-pyridylboronic Acid Pinacol Ester

2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-ca...

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile - [T25154]

741709-63-7

Boric Acid| Boric Acid Ester| Potassium Trifluoroborate| cyanide

Boronic ester

Organoborons

Pyridine