ChemicalBook > CAS DataBase List > 2-HYDROXY-4-IODO-BENZALDEHYDE

2-HYDROXY-4-IODO-BENZALDEHYDE

Product Name: 2-HYDROXY-4-IODO-BENZALDEHYDE
CAS No.: 38170-02-4
Chemical Name: 2-HYDROXY-4-IODO-BENZALDEHYDE
Synonyms: 4-Iodo-2-hydroxybenzaldehyde;2-HYDROXY-4-IODO-BENZALDEHYDE;BENZALDEHYDE, 2-HYDROXY-4-IODO-
CBNumber: CB0668831
Molecular Formula: C7H5IO2
Formula Weight: 248.02
MOL File: Mol file

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2-HYDROXY-4-IODO-BENZALDEHYDE Property

Melting point:: 87 °C
Boiling point:: 290.0±30.0 °C(Predicted)
Density: 2.039±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 7.32±0.10(Predicted)
color: Off-White

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Safety

HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0354916
Product name: 2-HYDROXY-4-IODOBENZALDEHYDE
Purity: 95.00%
Packaging: 5MG
Price: $502.6
Updated: 2021/12/16

Abosyn

Product number: 61-10218
Product name: 2-Hydroxy-4-iodobenzaldehyde
Purity: 95-98%
Packaging: 1g
Price: $540
Updated: 2021/12/16

Labseeker

Product number: SC-62102
Product name: BENZALDEHYDE,2-HYDROXY-4-IODO-
Purity: 95
Packaging: 5g
Price: $1717
Updated: 2021/12/16

Crysdot

Product number: CD12076958
Product name: 2-Hydroxy-4-iodobenzaldehyde
Purity: 95%
Packaging: 250mg
Price: $125
Updated: 2021/12/16

Chemcia Scientific

Product number: CC00-2048
Product name: 2-Hydroxy-4-iodo-benzaldehyde
Purity: ＞98%
Packaging: 0.5g
Price: $175
Updated: 2021/12/16

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2-HYDROXY-4-IODO-BENZALDEHYDE Chemical Properties,Usage,Production

Uses

2-hydroxy-4-iodobenzaldehyde is used in the preparation of anti-B7-H3 antibodies.

Synthesis

50-00-0

533-58-4

38170-02-4

Step 1: Preparation of 2-hydroxy-4-iodobenzaldehyde Magnesium chloride (MgCl2, 19.5 g, 204 mmol) was added batchwise to a frozen solution of commercially available 2-iodophenol (30 g, 136 mmol) in acetonitrile (ACN) while keeping the reaction temperature below 10 °C. Paraformaldehyde (28.6 g, 954 mmol) and triethylamine (TEA, 76 mL, 545 mmol) were subsequently added and the reaction was exothermic to 15 °C. The reaction mixture was heated to 72 °C and maintained for 2 hours. Upon completion of the reaction, it was cooled to room temperature, poured into saturated aqueous ammonium chloride solution (500 mL) and extracted with ethyl acetate (2 x 150 mL). The organic phases were combined and washed sequentially with aqueous sodium bicarbonate (NaHCO3) (2 × 150 mL), aqueous 1N hydrochloric acid (HCl) (2 × 150 mL) and brine (2 × 150 mL). The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel, 5% ethyl acetate/hexane). The target fractions were collected, combined and the solvent was removed under reduced pressure to give 2-hydroxy-4-iodobenzaldehyde (27 g, 79% yield) as a yellow solid. The salicylaldehyde derivative was of suitable purity and could be used directly in the subsequent reaction.

References

[1] Patent: WO2006/40676, 2006, A1. Location in patent: Page/Page column 51
[2] Patent: WO2004/87686, 2004, A2. Location in patent: Page 12-130
[3] Patent: WO2004/87687, 2004, A1. Location in patent: Page 12-130
[4] Patent: WO2006/40672, 2006, A1. Location in patent: Page/Page column 59

2-HYDROXY-4-IODO-BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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38170-02-4, 2-HYDROXY-4-IODO-BENZALDEHYDERelated Search:

2-METHOXY-4-(TRIFLUOROMETHOXY)BENZALDEHYDE 2-Bromo-3-fluoro-6-methoxybenzaldehyde 2-Fluoro-3,4-dimethoxy-benzaldehyde 2-methoxy-3-(trifluoromethoxy)benzaldehyde 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE 2,5-Dibromo-3-fluorobenzaldehyde 2-bromo-6-chloro-4-fluorobenzaldehyde Benzaldehyde, 2-bromo-6-(difluoromethoxy)- 2-BROMO-4-FLUORO-6-METHYLBENZALDEHYDE 2-Fluoro-5-methylbenzaldehyde 2,4-DIFLUORO-3-METHOXYBENZALDEHYDE 2-bromo-5-methyl-4-nitrobenzaldehyde 3,4-Dichloro-5-(trifluoromethyl)benzaldehyde 2-bromo-3-fluoro-6-hydroxybenzaldehyde 2-Chloro-4-trifluoroMethoxy-benzaldehyde Cupric acetate monohydrate Salicylaldoxime Calcium chloride

2-HYDROXY-4-IODO-BENZALDEHYDE

BENZALDEHYDE, 2-HYDROXY-4-IODO-

4-Iodo-2-hydroxybenzaldehyde

38170-02-4