ChemicalBook > CAS DataBase List > GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

Product Name
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
CAS No.
217082-58-1
Chemical Name
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
Synonyms
APELIN-13;QRPRLSHKGPMPF;PREPRO-65-77-APELIN;Apelin (1-13) (human);APELIN-13 (HUMAN, BOVINE);apelin-13 trifluoroacetate salt;APELIN-13 (HUMAN, BOVINE, MOUSE, RAT);Apelin-13 trifluoroacetate salt >=95%;Apelin-13, human, bovine, mouse, rat (2);GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
CBNumber
CB0671552
Molecular Formula
C69H111N23O16S
Formula Weight
1550.83
MOL File
217082-58-1.mol
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GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Property

Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in PBS (pH 7.2) at approximately 10 mg/ml.
pka
3.56±0.10(Predicted)
form 
Lyophilized powder
Sequence
H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A6469
Product name
Apelin-13 trifluoroacetate salt
Purity
≥95%
Packaging
1mg
Price
$202.8
Updated
2024/03/01
Alfa Aesar
Product number
J66620
Product name
Apelin-13, human, bovine
Packaging
1mg
Price
$147
Updated
2023/06/20
Alfa Aesar
Product number
J66620
Product name
Apelin-13, human, bovine
Packaging
0.5mg
Price
$73.4
Updated
2021/12/16
Cayman Chemical
Product number
13523
Product name
Apelin-13
Purity
≥95%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
13523
Product name
Apelin-13
Purity
≥95%
Packaging
5mg
Price
$249
Updated
2024/03/01
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GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Chemical Properties,Usage,Production

Uses

Apelin-13 trifluoroacetate salt has been used to determine whether apelin promotes progression of diabetic nephropathy (DN) by inducing podocyte dysfunction. It has also been used to examine the effects of apelin on myocardial infarction (MI) injury and underlying mechanisms.

Uses

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM (the EC50 values for apelin-17 and apelin-36 are 2.5 and 20 nM, respectively). It acts primarily in the periphery and central nervous system, playing important roles in regulating cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity. Unlike apelin-36, apelin-13 poorly blocks the entry of human immunodeficiency virus into cells.

Uses

An endogenous ligand of Apelin Receptor (APLNR/APJ receptor) that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity.

Definition

ChEBI: Apelin-13 is a 13 amino acid oligopeptide which is the ligand for the apelin receptor (also known as the APJ receptor). It exhibits hypotensive and neuroprotective effects, and may be a potential prognostic biomarker for acute ischemic stroke and multiple sclerosis. It has a role as an antihypertensive agent, a biomarker, an autophagy inhibitor, a neuroprotective agent and a human metabolite. It is a conjugate base of an apelin-13(3+).

General Description

Apelin is a regulatory peptide and a ligand of the APJ receptor. It is a member of the G protein-coupled receptor family. Apelin and APJ are broadly dispersed in the body.

Biological Activity

apelin-13 is an endogenous ligand of the apj receptor.the apelin receptor apj, one of a group of g-proteincoupled receptors (gpcr), have recently been paired with their cognate peptide ligands using ‘‘reverse pharmacology’’, and functional evidence suggests a role for this receptor in the regulation of cardiovascular function, fluid homeostasis, and as a coreceptor for hiv infection.

Biochem/physiol Actions

Apelin plays physiological roles in the cytoprotection of many internal organs. It is used to treat insulin resistance and hypertension, but it may also can act as a negative factor. Apelin also regulates cardiovascular diseases.

in vitro

apelin-13 was identified as an endogenous ligand of the apj receptor, which could activate this g protein-coupled receptor with an ec50 value of 0.37 nm. in addition, the ec50 values for apelin-17 and apelin-36 have been found to be 2.5 and 20 nm, respectively [1].

in vivo

in a previous study, urethane anaesthetised, paralysed and ventilated male sd rats were used to investigate the action of apelin-13 directly microinjected into the nucleus tractus solitarius (nts) and the rostral ventrolateral medulla (rvlm) on arterial pressure and phrenic nerve activity. results showed that apelin-13 microinjections into the nts led to either apnea or decreased phrenic nerve discharge amplitude by up to 30%. in the rvlm, apelin-13 caused increase in phrenic nerve discharge amplitude depending on the exact site of injection [2].

IC 50

0.37 nm for gpcr

References

[1] lee, d. k.,cheng, r.,nguyen, t., et al. characterization of apelin, the ligand for the apj receptor. journal of neurochemistry 74, 34-41 (2000).
[2] seyedabadi m, goodchild ak, pilowsky pm. site-specific effects of apelin-13 in the rat medulla oblongata on arterial pressure and respiration. auton neurosci. 2002 oct 31;101(1-2):32-8.
[3] a g japp, n l cruden, g barnes, n van gemeren, j mathews, j adamson, n r johnston, m a denvir, i l megson, a d flapan, d e newby. acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure. circulation 2010 april 27, 121 (16): 1818-27.

GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Preparation Products And Raw materials

Raw materials

Preparation Products

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GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Suppliers

MedChemexpress LLC
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GenScript Corporation
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Chem-Impex International, Inc.
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View Lastest Price from GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE manufacturers

Career Henan Chemical Co
Product
GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE 217082-58-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13

217082-58-1, GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHERelated Search:


  • apelin-13 trifluoroacetate salt
  • Apelin-13, human, bovine, mouse, rat (2)
  • Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe ((2) Due to the presence of a Gln in N-terMinal position this peptide can contain the pyroglutaMic forM)
  • Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
  • L-Phenylalanine, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-
  • QRPRLSHKGPMPF
  • PREPRO-65-77-APELIN
  • H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH
  • GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
  • APELIN-13
  • APELIN-13 (HUMAN, BOVINE)
  • APELIN-13 (HUMAN, BOVINE, MOUSE, RAT)
  • Apelin-13 (human, bovine, mouse, rat) H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
  • Apelin-13 trifluoroacetate salt >=95%
  • GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE USP/EP/BP
  • Apelin 13 triTFA(217082 58 1(free base)),Apelin13 triTFA(217082581(free base))
  • Apelin (1-13) (human)
  • 217082-58-1
  • C69H111N23O16SC2F3O2
  • C69H111N23O16S
  • Apelin receptor
  • Peptide
  • Elisa Kit-Mouse Elisa Kit