1-Methylpyrrolidine Property

Melting point:

-90 °C

Boiling point:

76-80 °C (lit.)

Density 

0.800 g/mL at 20 °C (lit.)

vapor pressure 

100 hPa (20 °C)

refractive index 

n20/D 1.425

Flash point:

−7 °F

storage temp. 

Store below +30°C.

solubility 

213g/l

form 

Liquid

pka

10.32(at 25℃)

color 

Clear colorless

PH

11.3 (1g/l, H2O)

explosive limit

1.1-9.1%(V)

Water Solubility 

fully miscible

BRN 

102445

InChIKey

AVFZOVWCLRSYKC-UHFFFAOYSA-N

LogP

1.1 at 23℃

CAS DataBase Reference

120-94-5(CAS DataBase Reference)

NIST Chemistry Reference

Pyrrolidine, 1-methyl-(120-94-5)

EPA Substance Registry System

N-Methylpyrrolidine (120-94-5)

Safety

Hazard Codes 

F,C,N

Risk Statements 

11-22-34-51/53-35-20/22

Safety Statements 

16-26-36/37/39-45-61-29

RIDADR 

UN 2924 3/PG 2

WGK Germany 

2

RTECS 

UY1420500

Autoignition Temperature

170 °C DIN 51794

TSCA 

Yes

HS Code 

2933 99 80

HazardClass 

3

PackingGroup 

II

Toxicity

LD50 orally in Rabbit: 280 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1-Methylpyrrolidine Chemical Properties,Usage,Production

Chemical Properties

colorless transparent volatile liquid. Freely soluble in water, soluble in alcohol, ether and other organic solvents.

Uses

1-Methylpyrrolidine is a methylated pyrollidine and is involved as an essential part of the structure of cefipime. It is also an active component of cigarette smoke.

Preparation

n-methylpyrrolidine was successfully synthesized in an aqueous medium by using methylamine and 1,4-dibromobutane in the presence of catalyst k2co3 at a moderated temperature. here, n-methylpyrrolidine was firstly synthesized via the green chemistry process, in which both the water solvent and potassium carbonate catalyst were inexpensive and environmentally friendly. also, the reaction temperature was quite moderated at 90°C.
green organic synthesis of n-methylpyrrolidine

Hazard

Flammable, dangerous fire risk. Irritant toskin and eyes.

Flammability and Explosibility

Highly flammable

Safety Profile

Poison by intraperitoneal and intravenous routes. This material is strongly alkaline. Liquid and vapors are corrosive to the skin, eyes, or mucous membranes. A very dangerous fire hazard; keep away from sparks, heat sources, and powerful oxidizers. Keep in closed containers. To fight fire, use alcohol foam. When heated to decomposition it emits highly toxic fumes of NOx.