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Azelastine

Product Name
Azelastine
CAS No.
58581-89-8
Chemical Name
Azelastine
Synonyms
-4-yl)-;AZELASTINE;SPBio_000657;KBio3_002992;CAS 790307-93-0;Azelastine base;Spectrum3_001984;Spectrum2_000649;Azeptin：Rhino1ast;Azelastine USP/EP/BP
CBNumber
CB6256007
Molecular Formula
C22H24ClN3O
Formula Weight
381.9
MOL File
58581-89-8.mol
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Azelastine Property

Melting point:
111 - 115°C
Boiling point:
533.9±60.0 °C(Predicted)
Density 
1.1505 (rough estimate)
refractive index 
1.5790 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
pka
pKa 9.82(H2O t=25 I=0.025) (Uncertain)
form 
Solid
color 
White to Off-White
BCS Class
1?
Stability:
Stable under recommended storage conditions., Stable Under Recommended Storage C
CAS DataBase Reference
58581-89-8(CAS DataBase Reference)
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Safety

Hazardous Substances Data
58581-89-8(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A767410
Product name
Azelastine
Packaging
100mg
Price
$100
Updated
2021/12/16
TRC
Product number
A767410
Product name
Azelastine
Packaging
2.5g
Price
$610
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC130471
Product name
4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
Packaging
100mg
Price
$72
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC130471
Product name
4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
Packaging
250mg
Price
$145
Updated
2021/12/16
Matrix Scientific
Product number
099439
Product name
4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
Purity
95+%
Packaging
250mg
Price
$189
Updated
2021/12/16
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Azelastine Chemical Properties,Usage,Production

Description

Azelastine has potent, long-lasting histamine H1-receptor blocking activity and several other interesting anti-inflammatory properties related to its antiallergic efficacy .

Uses

anesthetic, anticonvulsant

Definition

ChEBI: A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.

brand name

Astelin (Medpointe); Optivar (Medpointe).

Clinical Use

Azelastine, although not a close structural analogue to the benzimidazoles, has some structural similarities to them. It is used as a nasal spray for allergic rhinitis and as eye drops for allergic conjunctivitis.Like olopatadine, azelastine also stabilizes mast cells, preventing degranulation and subsequent release of histamine, leukotrienes, and PGD2. It is available in Europe for systemic use in the treatment of asthma and seasonal allergies. Besides antihistaminic effects, it also may block release of histamine and other inflammatory mediators from mast cells. When administered orally, the N-dealkylated metabolite appears to contribute significantly to its pharmacological effects.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and Cl- .

Azelastine Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 1-Methylpyrrolidine 4-(4-Chloro-benzyl)-2H-phthalazin-1-one Hydrazine sulfate Diphenylmethane Acetophenone

Preparation Products

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Azelastine Suppliers

China 111 Europe 3 India 8 United Kingdom 5 United States 25 Global 152
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ:2779667926
Email
buy@fortunachem.com
Country
China
ProdList
2792
Advantage
58
Qingdao Ruifengyuan Chemical Co., Ltd.
Tel
13375559818
Email
cfy69@163.com
Country
China
ProdList
299
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2045
Advantage
56
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2028
Advantage
58
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View Lastest Price from Azelastine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Azelastine 58581-89-8
Price
US $0.00/g/Bag
Min. Order
10g
Purity
98%min
Supply Ability
120kg/month
Release date
2021-06-05
Guangzhou PI PI BIOTECH INC
Product
Azelastine 58581-89-8
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2021-09-04
Career Henan Chemical Co
Product
1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin 58581-89-8
Price
US $20.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
20kg
Release date
2018-07-27

58581-89-8, AzelastineRelated Search:

METHYL THIOPHENE-2-CARBOXYLATE Methyl acetate Methylparaben Methyl acrylate 2,6-DIMETHYLNAPHTHALENE 2-Methylnaphthalene Bensulfuron methyl Thiophanate-methyl 1-AdaMantanethylaMine Kresoxim-methyl DBU Chlorodimethylphenylsilane Triphenylphosphine Methyl Phenylacetone Sibutramine hydrochloride Parathion-methyl AZELASTINE HCL,AZELASTINE HYDROCHLORIDE

  • 1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin
  • 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinon
  • 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
  • 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1-one
  • 4-[(4-chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)-1-phthalazinone
  • 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one
  • Azelastinum [INN-Latin]
  • KBio3_002992
  • SPBio_000657
  • Spectrum2_000649
  • Spectrum3_001984
  • 4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methyl-4-azepanyl]-1-phthalazinone
  • -4-yl)-
  • AZELASTINE
  • 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-
  • 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one
  • CAS 790307-93-0
  • Azeptin：Rhino1ast
  • 2-(Hexahydro-1-methyl-1H-azepin-4-yl)-4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one
  • 4-(p-Chlorobenzyl)-2-(1-methylhexahydro-1H-azepin-4-yl)phthalazin-1(2H)-one
  • 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone
  • Azelastine & Azelastine Hydrochloride
  • Azelastine base
  • 4-[(4-chlorophenyl)Methyl]-2-[(4S)-1-Methylazepan-4-yl]-1,2-dihydrophthalazin-1-one
  • 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-y1)-1(2H)-phthalazinone
  • 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one
  • 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2
  • Azelastine USP/EP/BP
  • Phenylpyruvic Acid Impurity 7
  • 58581-89-8
  • 53408-27-6
  • C22H26ClN3O
  • TELAZOL
  • API