ChemicalBook > CAS DataBase List > 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine

Product Name
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
CAS No.
61337-89-1
Chemical Name
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
Synonyms
1-(3-HYDROXYMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE;1-(3-HYDROXYMETHYL PYRIDIN-2-YL)-2-PHENYL-4-METHYL PIPERAZINE;Misoprolol;Mirtazapine IMpurity B;Mirtazapine EP IMpurity B;1-(3-Hydroxymethylpyridin-2-Yl;Mirtazapine Penutimate Impurity-B;[2-[(2RS)-4-Methyl-2-phenylpiperazi;Mirtazapine Impurity 2(Mirtazapine EP Impurity B);2-(4-METHYL-2-PHENYL-1-PIPERAZINYL)-3-PYRIDINEMETHANOL
CBNumber
CB1263044
Molecular Formula
C17H21N3O
Formula Weight
283.37
MOL File
61337-89-1.mol
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1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Property

Melting point:
113-115°C
Boiling point:
478.8±45.0 °C(Predicted)
Density 
1.161±0.06 g/cm3(Predicted)
vapor pressure 
0-0Pa at 20-25℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Solid
pka
13.59±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C17H21N3O/c1-19-10-11-20(17-15(13-21)8-5-9-18-17)16(12-19)14-6-3-2-4-7-14/h2-9,16,21H,10-13H2,1H3
InChIKey
PYZPABZGIRHQTA-UHFFFAOYSA-N
SMILES
C1(N2CCN(C)CC2C2=CC=CC=C2)=NC=CC=C1CO
LogP
1.3 at 20℃
Surface tension
59.72N/m at 1g/L and 20℃
CAS DataBase Reference
61337-89-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M320640
Product name
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol
Packaging
100mg
Price
$55
Updated
2021/12/16
TRC
Product number
M320640
Product name
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol
Packaging
500mg
Price
$105
Updated
2021/12/16
TRC
Product number
M320640
Product name
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol
Packaging
2.5g
Price
$275
Updated
2021/12/16
Alichem
Product number
61337891
Product name
1-(3-Hydroxymethylpyridyl-2)-2-phenyl-4-methylpyperazine
Packaging
5g
Price
$280.8
Updated
2021/12/16
Ambeed
Product number
A232000
Product name
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol
Purity
95%
Packaging
25g
Price
$446
Updated
2021/12/16
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1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol is an impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.

Uses

An impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.

Synthesis

61338-13-4

61337-89-1

General procedure for the synthesis of 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol from 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinecarboxylic acid: 1618 mL (1618 mmol) of a 1 mol/L lithium aluminum hydride solution in tetrahydrofuran was added to a 2 L four-necked flask equipped with stirring blades and a thermometer. Subsequently, 120 g (404 mmol) of 2-(4-methyl-2-phenyl-1-piperazine)-3-pyridinecarboxylic acid was dissolved in 1800 mL of tetrahydrofuran, the reaction temperature was maintained at about 25 °C and the solution was added slowly dropwise to the reaction flask over a period of 30 min. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 25°C for 3 hours. Upon completion of the reaction, 70 mL of water was slowly added while the reaction solution was cooled with a water bath and the mixture was stirred. After that, the organic and aqueous layers were separated, and the organic layer was washed sequentially with 70 mL of 15 wt% aqueous sodium hydroxide solution and 200 mL of water. The organic layer was concentrated under reduced pressure to give a crude product of 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol. To the crude product was added 840 mL of isopropyl acetate, heated to 60°C to dissolve it completely, and then 840 mL of heptane was added slowly and dropwise at an internal temperature of not less than 50°C. The resulting solution was cooled to 5°C and the slurry was aged at that temperature for 2 hours. Subsequently, the solid was collected by vacuum filtration and the crystals obtained by filtration were washed with a mixture of 60 mL of isopropyl acetate and 60 mL of heptane. Finally, the white crystals were dried under reduced pressure at 40 °C for 5 h to obtain 102 g (363 mmol, yield: 89%) of 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridine methanol with a purity of 99.53% and a water content of 320 ppm.

References

[1] Patent: US2002/35255, 2002, A1
[2] Organic Preparations and Procedures International, 2007, vol. 39, # 4, p. 399 - 402
[3] Patent: JP2017/39659, 2017, A. Location in patent: Paragraph 0048-0049
[4] Patent: JP2017/88565, 2017, A. Location in patent: Paragraph 0060; 0061
[5] Patent: JP2017/88564, 2017, A. Location in patent: Paragraph 0056; 0057

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Suppliers

Canada 1 China 156 Europe 2 Germany 1 India 11 Ukraine 1 United Kingdom 5 United States 17 Global 194
Jiangxi Fanlai Biomedical Technology Co., Ltd.
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View Lastest Price from 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine manufacturers

Hangzhou Verychem Science And Technology Co.Ltd
Product
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine 61337-89-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20 tons
Release date
2025-03-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine 61337-89-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine 61337-89-1
Price
US $1.00/kg
Min. Order
1kg
Purity
98%min
Supply Ability
as request
Release date
2018-12-23

61337-89-1, 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazineRelated Search:

Chlorodimethylphenylsilane 2,4,6-Collidine Azamethiphos 2,6-Lutidine Methylparaben Bensulfuron methyl 4-Methylpyridine Kresoxim-methyl METHYL THIOPHENE-2-CARBOXYLATE 1-Methylpiperazine p-Naphtholbenzein 2-(Hydroxymethyl)pyridine 2-Chloro-5-chloromethylpyridine Methyl acetate Methyl acrylate Thiophanate-methyl Methyl Micafungin sodium

  • [2-(4-METHYL-2-PHENYLPIPERAZIN-1-YL)PYRIDIN-3-YL]METHANOL
  • 2-(4-METHYL-2-PHENYL-1-PIPERAZINYL)-3-PYRIDINEMETHANOL
  • 1-(3-HYDROXYMETHYL PYRIDIN-2-YL)-4-METHYL-2-PHENYL PIPERAZINE
  • 1-(3-HYDROXYMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE
  • 1-(3-HYDROXIDMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE
  • 1-(3-Hydroxymethylpyridyl-2)-2-Phenyl-4-Methylpyperazine
  • 1-(3-Hydroxymethylpyridin-2-Yl
  • 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol (intermediate of mirtazapine)
  • 2-[(2-chloro-phenyl)-acetyl benzoic acid (intermediate of azelastine hcl)
  • 2-[(2-phenyl-4-methyl)-piperazine-1-yl]pyridine-3-methanol (intermediate of mirtazapine)
  • 1--3--2-(4-METHYL-2-PHENYL-1-PIPERAZINE)-3-PYRIDINE METHANOL (PREPARATION FOR MIRTAZAPINE)
  • D-(+)-METHYL-ALPHA-(2-THIENYLETHAMINO)(2-CHLOROPHENYL)ACETATEHCL
  • 2-[(2-PHENYL-4-METHYL)-PIPERAZINE-1-YL]PYRIDINE-3-METHANO
  • 1-(3-HydroxyMethyl-2-pyridyl)-4-Methyl-2-phenylpiperazine
  • 2-(4-Methyl-2-phenylpiperazin-1-yl)pyridine-3-Methanol
  • Mirtazapine IMpurity B
  • 1-(3-hydroxy Methyl pyridine-2-yl)-4-Methyl-2-phenyl piperazine
  • 3-Pyridinemethanol, 2-(4-methyl-2-phenyl-1-piperazinyl)-
  • 1-(3-HYDROXYMETHYL PYRIDIN-2-YL)-2-PHENYL-4-METHYL PIPERAZINE
  • Mirtazapine EP IMpurity B
  • 1-(3-HYDROXY METHYL PYRIDYL-2-)2 PHENYL 4 METHYL PIPERAZINE [MRT-6]
  • Mirtazapine Impurity 2(Mirtazapine EP Impurity B)
  • Mirtazapine EP Impurity B/[2-[(2RS)-4-Methyl-2-phenylpiperazin-1-yl]pyridin-3-yl]methanol
  • [2-[(2RS)-4-Methyl-2-phenylpiperazi
  • 1-(3-HydroxyMethyl pyridyl-2)-2-phenyl-4-methyl Piperazine (N-1 Intermdediate)
  • (3-Hydroxymethylpyridyl-2)-2-phenyl-4-methylpyperazine
  • Misoprolol
  • Mirtazapine Penutimate Impurity-B
  • 1-(3-Hydroxymethyl-2-pyridinyl)-2-phenyl-4-methylpiperazine
  • 61337-89-1
  • C17H21N3O
  • Intermediate Mirtazapine
  • l(intermediate of mirtazapine)
  • Aromatics
  • Heterocycles
  • Miscellaneous Reagents
  • Alkohols
  • Organic acids
  • Piperazine derivates
  • (intermediate of mirtazapine)
  • (intermediate of azelastine hcl)