ChemicalBook > CAS DataBase List > Azelastine

Azelastine

Product Name
Azelastine
CAS No.
58581-89-8
Chemical Name
Azelastine
Synonyms
-4-yl)-;AZELASTINE;SPBio_000657;KBio3_002992;CAS 790307-93-0;Azelastine base;Spectrum3_001984;Spectrum2_000649;Azeptin：Rhino1ast;Azelastine USP/EP/BP
CBNumber
CB6256007
Molecular Formula
C22H24ClN3O
Formula Weight
381.9
MOL File
58581-89-8.mol
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Azelastine Property

Melting point:
111 - 115°C
Boiling point:
533.9±60.0 °C(Predicted)
Density 
1.1505 (rough estimate)
refractive index 
1.5790 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
pka
pKa 9.82(H2O t=25 I=0.025) (Uncertain)
form 
Solid
color 
White to Off-White
BCS Class
1?
Stability:
Stable under recommended storage conditions., Stable Under Recommended Storage C
CAS DataBase Reference
58581-89-8(CAS DataBase Reference)
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Safety

Hazardous Substances Data
58581-89-8(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A767410
Product name
Azelastine
Packaging
2.5g
Price
$610
Updated
2021/12/16
TRC
Product number
A767410
Product name
Azelastine
Packaging
100mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC130471
Product name
4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
Packaging
250mg
Price
$145
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC130471
Product name
4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
Packaging
100mg
Price
$72
Updated
2021/12/16
AK Scientific
Product number
C809
Product name
Azelastine
Packaging
1g
Price
$617
Updated
2021/12/16
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Azelastine Chemical Properties,Usage,Production

Description

Azelastine has potent, long-lasting histamine H1-receptor blocking activity and several other interesting anti-inflammatory properties related to its antiallergic efficacy .

Uses

anesthetic, anticonvulsant

Definition

ChEBI: A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.

brand name

Astelin (Medpointe); Optivar (Medpointe).

Clinical Use

Azelastine, although not a close structural analogue to the benzimidazoles, has some structural similarities to them. It is used as a nasal spray for allergic rhinitis and as eye drops for allergic conjunctivitis.Like olopatadine, azelastine also stabilizes mast cells, preventing degranulation and subsequent release of histamine, leukotrienes, and PGD2. It is available in Europe for systemic use in the treatment of asthma and seasonal allergies. Besides antihistaminic effects, it also may block release of histamine and other inflammatory mediators from mast cells. When administered orally, the N-dealkylated metabolite appears to contribute significantly to its pharmacological effects.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and Cl- .

Azelastine Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 1-Methylpyrrolidine 4-(4-Chloro-benzyl)-2H-phthalazin-1-one Hydrazine sulfate Diphenylmethane Acetophenone

Preparation Products

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Azelastine Suppliers

China 110 Europe 3 India 8 United Kingdom 5 United States 23 Global 149
Wuhan Fortuna Chemical Co., Ltd
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China Langchem Inc.
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TargetMol Chemicals Inc.
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View Lastest Price from Azelastine manufacturers

Guangzhou PI PI BIOTECH INC
Product
Azelastine 58581-89-8
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2021-09-04
Hebei Duling International Trade Co. LTD
Product
Azelastine 58581-89-8
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-04-18
Shaanxi Dideu Medichem Co. Ltd
Product
Azelastine 58581-89-8
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08

58581-89-8, AzelastineRelated Search:

METHYL THIOPHENE-2-CARBOXYLATE Methyl acetate Methylparaben Methyl acrylate 2,6-DIMETHYLNAPHTHALENE 2-Methylnaphthalene Bensulfuron methyl Thiophanate-methyl 1-AdaMantanethylaMine Kresoxim-methyl DBU Chlorodimethylphenylsilane Triphenylphosphine Methyl Phenylacetone Sibutramine hydrochloride Parathion-methyl AZELASTINE HCL,AZELASTINE HYDROCHLORIDE

  • 1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin
  • 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinon
  • 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
  • 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1-one
  • 4-[(4-chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)-1-phthalazinone
  • 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one
  • Azelastinum [INN-Latin]
  • KBio3_002992
  • SPBio_000657
  • Spectrum2_000649
  • Spectrum3_001984
  • 4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methyl-4-azepanyl]-1-phthalazinone
  • -4-yl)-
  • AZELASTINE
  • 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-
  • 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one
  • CAS 790307-93-0
  • Azeptin：Rhino1ast
  • 2-(Hexahydro-1-methyl-1H-azepin-4-yl)-4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one
  • 4-(p-Chlorobenzyl)-2-(1-methylhexahydro-1H-azepin-4-yl)phthalazin-1(2H)-one
  • 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone
  • Azelastine & Azelastine Hydrochloride
  • Azelastine base
  • 4-[(4-chlorophenyl)Methyl]-2-[(4S)-1-Methylazepan-4-yl]-1,2-dihydrophthalazin-1-one
  • 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-y1)-1(2H)-phthalazinone
  • 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one
  • 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2
  • Azelastine USP/EP/BP
  • Phenylpyruvic Acid Impurity 7
  • 58581-89-8
  • 53408-27-6
  • C22H26ClN3O
  • TELAZOL
  • API