(-)-[3R,4S]-CHROMANOL 293B

Product Name: (-)-[3R,4S]-CHROMANOL 293B
CAS No.: 163163-24-4
Chemical Name: (-)-[3R,4S]-CHROMANOL 293B
Synonyms: (-)-[3R;(-)-Chromanol 293B;4S]-Chromanol 293B;(-)-[3R,4S]-Chromano;(-)-[3R,4S]-Chromanol 293B;(?)-[3R,4S]-Chromanol 293B;Chromanol 293B [3R,4S]-(-)-;( ) Chromanol 293B,()Chromanol 293B;N-((3R,4S)-6-Cyano-3-hydroxy-2,2-dimethylchroman-4-yl)-N-methylethanesulfonamide;N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
CBNumber: CB0677882
Molecular Formula: C15H20N2O4S
Formula Weight: 324.4
MOL File: 163163-24-4.mol

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(-)-[3R,4S]-CHROMANOL 293B Property

Melting point:: 192 °C
Boiling point:: 474.1±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: 18 mg/mL
form: solid
pka: 12.96±0.60(Predicted)
color: white

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36/37-7/9
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C350260
Product name: (-)-[3R,4S]-Chromanol293B
Packaging: 1mg
Price: $45
Updated: 2021/12/16

ApexBio Technology

Product number: B6753
Product name: (-)-[3R,4S]-Chromanol293B
Packaging: 10mg
Price: $297
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0004091
Product name: (-)-(3R,4S)-CHROMANOL 293B
Purity: 95.00%
Packaging: 5MG
Price: $505.26
Updated: 2021/12/16

ApexBio Technology

Product number: B6753
Product name: (-)-[3R,4S]-Chromanol293B
Packaging: 50mg
Price: $1253
Updated: 2021/12/16

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(-)-[3R,4S]-CHROMANOL 293B Chemical Properties,Usage,Production

Uses

(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K+ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic[1].

Definition

ChEBI: Chromanol 293B is a 1-benzopyran.

Biological Activity

Enantiomer that selectively inhibits the slow component of delayed rectifier K + current (I Ks ). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC 50 values are 1.36 and 9.6 μ M respectively). Has negligible inhibitory action at hERG channels (IC 50 > 30 μ M).

storage

Room temperature

References

[1] Yang IC, et al. Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J Pharmacol Exp Ther. 2000;294(3):955-962. PMID:10945846

(-)-[3R,4S]-CHROMANOL 293B Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-[3R,4S]-CHROMANOL 293B Suppliers

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163163-24-4, (-)-[3R,4S]-CHROMANOL 293BRelated Search:

CHROMANOL 293B (-)-[3R,4S]-CHROMANOL 293B 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE (R)-3-(1-aminoethyl)benzonitrile 4-TERT-BUTOXYBENZONITRILE 2-(3-CYANO-PHENYL)ETHANOL

N-[(3R,4S)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYLETHANESULFONAMIDE

Chromanol 293B [3R,4S]-(-)-

Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-

(-)-[3R,4S]-Chromano

(-)-[3R

(-)-[3R,4S]-Chromanol 293B

4S]-Chromanol 293B

(-)-Chromanol 293B

( ) Chromanol 293B,()Chromanol 293B

N-((3R,4S)-6-Cyano-3-hydroxy-2,2-dimethylchroman-4-yl)-N-methylethanesulfonamide

N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

(?)-[3R,4S]-Chromanol 293B

163163-24-4

Potassium channel