CHROMANOL 293B

Product Name: CHROMANOL 293B
CAS No.: 163163-23-3
Chemical Name: CHROMANOL 293B
Synonyms: Chromagnol;CHROMANOL 293B;Chromanol 293B >=98% (HPLC), powder;6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane;N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide;TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE;Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-
CBNumber: CB7710010
Molecular Formula: C15H20N2O4S
Formula Weight: 324.4
MOL File: 163163-23-3.mol

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CHROMANOL 293B Property

Boiling point:: 474.1±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 18 mg/mL
form: solid
pka: 12.96±0.60(Predicted)
color: white

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36/37-7/9
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2615
Product name: Chromanol 293B
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $124.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2615
Product name: Chromanol 293B
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $904
Updated: 2024/03/01

Cayman Chemical

Product number: 19993
Product name: Chromanol 293B
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19993
Product name: Chromanol 293B
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 19993
Product name: Chromanol 293B
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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CHROMANOL 293B Chemical Properties,Usage,Production

Description

Chromanol 293B is a blocker of slowly activating delayed-rectifier K⁺ current (I_Ks) with an IC₅₀ value of 6.89 μM in Xenopus oocytes expressing rat I_Ks channels. It is selective, having no activity at rat K_v1.1 or K_ir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of I_Ks in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl^- currents (I_CTFR) with an IC₅₀ value of 19 μM in Xenopus oocytes expressing human CTFR.

Uses

Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

Definition

ChEBI: Chromanol 293B is a 1-benzopyran.

General Description

Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).

Biological Activity

Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M).

Biochem/physiol Actions

Blocker of the slow delayed rectifier K+ current via KCNQ1 channels

storage

Room temperature

CHROMANOL 293B Preparation Products And Raw materials

Raw materials

Preparation Products

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CHROMANOL 293B Suppliers

China 28 Germany 2 India 1 Switzerland 1 United Kingdom 2 United States 9 Global 43

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8618
Advantage: 58

163163-23-3, CHROMANOL 293BRelated Search:

2,2-DIMETHYLCHROMANE Ethanesulfonamide (-)-[3R,4S]-CHROMANOL 293B,Chromanol 293B [3R,4S]-(-)- 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE CHROMANOL 293B 4-TERT-BUTOXYBENZONITRILE (S)-3-(1-Aminoethyl)benzonitrile 2-(3-CYANO-PHENYL)ETHANOL

N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide

TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE

CHROMANOL 293B

6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane

Chromagnol

Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-

Chromanol 293B >=98% (HPLC), powder

163163-23-3

Potassium channel