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CHROMANOL 293B

Product Name
CHROMANOL 293B
CAS No.
163163-23-3
Chemical Name
CHROMANOL 293B
Synonyms
Chromagnol;CHROMANOL 293B;Chromanol 293B >=98% (HPLC), powder;6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane;N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide;TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE;Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-
CBNumber
CB7710010
Molecular Formula
C15H20N2O4S
Formula Weight
324.4
MOL File
163163-23-3.mol
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CHROMANOL 293B Property

Boiling point:
474.1±55.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: 18 mg/mL
form 
solid
pka
12.96±0.60(Predicted)
color 
white
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36/37-7/9
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C2615
Product name
Chromanol 293B
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$224
Updated
2025/07/31
Sigma-Aldrich
Product number
C2615
Product name
Chromanol 293B
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$929
Updated
2025/07/31
Cayman Chemical
Product number
19993
Product name
Chromanol 293B
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19993
Product name
Chromanol 293B
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
19993
Product name
Chromanol 293B
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
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CHROMANOL 293B Chemical Properties,Usage,Production

Description

Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR.

Uses

Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

Definition

ChEBI: Chromanol 293B is a 1-benzopyran.

General Description

Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).

Biological Activity

Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M).

Biochem/physiol Actions

Blocker of the slow delayed rectifier K+ current via KCNQ1 channels

storage

Room temperature

References

[1] H. SUESSBRICH. Specific blockade of slowly activating IsK channels by chromanols — impact on the role of IsK channels in epithelia[J]. FEBS Letters, 1996, 396 2-3: 271-275. DOI: 10.1016/0014-5793(96)01113-1
[2] SUSUMU FUJISAWA  Toshihiko I  Kyoichi Ono. Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells[J]. British Journal of Pharmacology, 2009, 129 5: 1007-1013. DOI: 10.1038/sj.bjp.0703126
[3] A. BACHMANN U R U Quast. Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl– current[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2001, 363 1: 590-596. DOI: 10.1007/s002100100410

CHROMANOL 293B Preparation Products And Raw materials

Raw materials

Preparation Products

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CHROMANOL 293B Suppliers

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163163-23-3, CHROMANOL 293BRelated Search:

2,2-DIMETHYLCHROMANE Ethanesulfonamide (-)-[3R,4S]-CHROMANOL 293B,Chromanol 293B [3R,4S]-(-)- 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE CHROMANOL 293B 4-TERT-BUTOXYBENZONITRILE (S)-3-(1-Aminoethyl)benzonitrile 2-(3-CYANO-PHENYL)ETHANOL

  • N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide
  • TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE
  • CHROMANOL 293B
  • 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane
  • Chromagnol
  • Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-
  • Chromanol 293B >=98% (HPLC), powder
  • 163163-23-3
  • Potassium channel