2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE
- Product Name
- 2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE
- CAS No.
- 6127-18-0
- Chemical Name
- 2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE
- Synonyms
- TOSLAB 23085;4-BroMo-2-Methylindole;4-BroMo-2-Methyl-1H-indole;1H-Indole,4-bromo-2-methyl-;2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE
- CBNumber
- CB0680068
- Molecular Formula
- C9H8BrN
- Formula Weight
- 210.07
- MOL File
- Mol file
2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE Property
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C9H8BrN/c1-6-5-7-8(10)3-2-4-9(7)11-6/h2-5,11H,1H3
- InChIKey
- MXRPXKYWAYTGJY-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Br)=CC=C2)C=C1C
- CAS DataBase Reference
- 6127-18-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697288
- Product name
- 4-Bromo-2-methyl-1h-indole
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B697288
- Product name
- 4-Bromo-2-methyl-1h-indole
- Packaging
- 50mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- B697288
- Product name
- 4-Bromo-2-methyl-1h-indole
- Packaging
- 100mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- B697288
- Product name
- 4-Bromo-2-methyl-1h-indole
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB141962
- Product name
- 4-Bromo-2-methyl-1H-indole
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE Chemical Properties,Usage,Production
Synthesis
1232861-11-8
6127-18-0
The general procedure for the synthesis of 4-bromo-2-methyl-1H-indole using the compound (CAS:1232861-11-8) as starting material was as follows: sodium hydroxide (4.01 g, 0.1 mol) was added to a mixture of methanol (80 mL) and water (40 mL) of intermediate 3 (7.0 g, 20.1 mmol). The reaction mixture was stirred at 50 °C for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was extracted with dichloromethane (3 x 50 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel as stationary phase, petroleum ether/ethyl acetate=5:1 as eluent) to afford the target product 4-bromo-2-methyl-1H-indole 4 (3.0 g, 71% yield). Low resolution mass spectrometry (LRMS) (M+H+) m/z: calculated value 209.98; measured value 210.12.
References
[1] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 186; 187
[2] Patent: US2010/160647, 2010, A1. Location in patent: Page/Page column 18-19
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9480 - 9497
2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE Suppliers
- Tel
- --
- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from 2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE manufacturers
- Product
- 4-Bromo-2-methyl-1H-indole 6127-18-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10