4-BroMo-2-Methylbutan-2-ol
- Product Name
- 4-BroMo-2-Methylbutan-2-ol
- CAS No.
- 35979-69-2
- Chemical Name
- 4-BroMo-2-Methylbutan-2-ol
- Synonyms
- 4-BroMo-2-Methyl-2-butanol;4-BroMo-2-Methylbutan-2-ol;2-Butanol, 4-broMo-2-Methyl-;4-BroMo-2-hydroxy-2-Methylbutane;4-bromo-2-methyl-butan-2-ol - [B70111];4-BroMo-2-Methylbutan-2-ol ISO 9001：2015 REACH
- CBNumber
- CB32619955
- Molecular Formula
- C5H11BrO
- Formula Weight
- 167.04
- MOL File
- 35979-69-2.mol
4-BroMo-2-Methylbutan-2-ol Property
- Boiling point:
- 189.7±23.0 °C(Predicted)
- Density
- 1.371±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform, Ethyl Acetate
- pka
- 14.79±0.29(Predicted)
- form
- Oil
- color
- Brown
- InChI
- InChI=1S/C5H11BrO/c1-5(2,7)3-4-6/h7H,3-4H2,1-2H3
- InChIKey
- RBFVGQWGOARJRU-UHFFFAOYSA-N
- SMILES
- CC(C)(O)CCBr
Safety
- HS Code
- 2905599890
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B685265
- Product name
- 4-Bromo-2-methyl-2-butanol
- Packaging
- 1g
- Price
- $1110
- Updated
- 2021/12/16
- Product number
- 143927
- Product name
- 4-Bromo-2-methylbutan-2-ol
- Purity
- 95%
- Packaging
- 5g
- Price
- $1592
- Updated
- 2021/12/16
- Product number
- OR939949
- Product name
- 4-Bromo-2-methylbutan-2-ol
- Purity
- 95%
- Packaging
- 1g
- Price
- $573
- Updated
- 2021/12/16
- Product number
- 143927
- Product name
- 4-Bromo-2-methylbutan-2-ol
- Purity
- 95%
- Packaging
- 1g
- Price
- $589
- Updated
- 2021/12/16
- Product number
- 35424
- Product name
- 4-Bromo-2-methylbutan-2-ol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $890
- Updated
- 2021/12/16
4-BroMo-2-Methylbutan-2-ol Chemical Properties,Usage,Production
Chemical Properties
4-BroMo-2-Methylbutan-2-ol is Brown Oil
Uses
4-Bromo-2-methyl-2-butanol is a brominated tertiary alcohol used as a reagent in the preparation of vitamin D3 analogues.
Synthesis
539-74-2
75-16-1
35979-69-2
General procedure for the synthesis of 4-bromo-2-methyl-2-butanol from ethyl 3-bromopropionate and methylmagnesium bromide: To a solution of ethyl 3-bromopropionate (0.2 g, 1.2 mmol) in tetrahydrofuran (THF, 5 mL) was slowly added methylmagnesium bromide (2.4 mL, 2.4 mmol) at 0°C. The reaction mixture was stirred continuously until a thin layer chromatography (TLC) analysis showed complete consumption of the raw material. The reaction mixture was stirred continuously at 0°C until thin layer chromatography (TLC) analysis showed complete consumption of the raw material [Unfolding agent: petroleum ether/ethyl acetate (3:1), Rf value of the product was 0.3]. Upon completion of the reaction, the reaction was quenched with aqueous ammonium chloride (2 mL) at 0°C. The reaction mixture was extracted with ethyl acetate and water by partitioning. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by column chromatography using petroleum ether/ethyl acetate (3:1) as eluent to give 4-bromo-2-methyl-2-butanol (0.15 g, 75.1% yield) as a yellow oil.
References
[1] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 403
[2] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 2, p. 525 - 535
[3] Journal of Organometallic Chemistry, 1973, vol. 47, p. 337 - 350
[4] Tetrahedron Letters, 1992, vol. 33, # 1, p. 105 - 108
[5] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 10, p. 828 - 833
4-BroMo-2-Methylbutan-2-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BroMo-2-Methylbutan-2-ol manufacturers
- Product
- 4-BroMo-2-Methylbutan-2-ol 35979-69-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 4-Bromo-2-methylbutan-2-ol 35979-69-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09