CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])

Product Name: CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])
CAS No.: 84211-54-1
Chemical Name: CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])
Synonyms: CYCLO-SOMATOSTATIN;Somatostatin Antagonist;C[AMINOHEPTANOYL-PHE-DTRP-LYS-THR(BZL)];Cyclosomatostatin, Somatostatin antagonist.;cyclo-(7-ahep-phe-trp-lys-bzl-thr)-somatostati;CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]);somatostatin, cyclo-(7-Ahep-Phe-Trp-Lys-Bzl-Thr)-;Cyclo[7-aminoheptanoyl-L-phenylalanyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-threonyl];Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt
CBNumber: CB0683928
Molecular Formula: C44H57N7O6
Formula Weight: 779.97
MOL File: 84211-54-1.mol

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CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Property

Boiling point:: 1118.4±65.0 °C(Predicted)
Density: 1.147±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: H₂O: 1 mg/mL, clear, colorless
form: powder
pka: 12.83±0.70(Predicted)
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C4801
Product name: Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl])
Purity: ≥95% (HPLC), powder
Packaging: 1mg
Price: $360
Updated: 2024/03/01

TRC

Product number: C990125
Product name: Cyclosomatostatin
Packaging: 5mg
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004289
Product name: CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])
Purity: 95.00%
Packaging: 1MG
Price: $697.34
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC108684
Product name: Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt
Packaging: 10mg
Price: $775
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC108684
Product name: Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt
Packaging: 25mg
Price: $1684.75
Updated: 2021/12/16

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CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Chemical Properties,Usage,Production

Uses

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) has been used as a somatostatin antagonist to study its effects on sleep in rats to infer the role of endogenous somatostatin in the physiologic modulation of REM sleep (REMS) , as an somatostatin (SST) antagonist to study its effects on elemental-induced intestinal atrophy in rats , as an SST receptor antagonist to eliminate the effect of somatostatin on catecholamine .

Biological Activity

cyclosomatostatin is a non-selective somatostatin receptor antagonist.somatostatin is a regulatory hormone or tissue factor playing an inhibitory role in the normal regulation of several organ systems including hypothalamus and pituitary gland, central nervous system, gastrointestinal tract as well as pancreas.

Biochem/physiol Actions

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) (cSSTA) is a cyclic somatostatin (SST) analog and is a somatostatin receptor antagonist. It is involved in blocking the effect of somatostatin, such as airway β-adrenergic function and regulation of acetylcholine release. cSSTA is also involved in blocking the effect of somatostatin of hormone release and?corticotropin-releasing factor-induced suppression of gastric emptying.

in vitro

although cyclosomatostatin could fully block the effect of somatostatin, it only partially reversed the inhibitory effect of cortistatin, a new anti-inflammatory peptide. this observation was further supported by the fact that cyclosomatostatin reversed the antiinfl ammatory effect of somatostatin and octreotide in vitro completely, while only partially reversing the effect of cortistatin [1].

in vivo

the effect of cortistatin was found to be dose dependent, with dose as low as 0.5 nmol (50 μg/kg) being partially protective. in contrast, cyclosomatostatin, somatostatin as well as octreotide were not protective [1].

storage

Store at -20°C

References

[1] gonzalez-rey e,chorny a,robledo g,delgado m. cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia. j exp med.2006 mar 20;203(3):563-71.

CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Suppliers

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View Lastest Price from CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) manufacturers

Career Henan Chemical Co

Product: CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) 84211-54-1
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-03-05

84211-54-1, CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])Related Search:

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CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])

CYCLO-SOMATOSTATIN

C[AMINOHEPTANOYL-PHE-DTRP-LYS-THR(BZL)]

somatostatin, cyclo-(7-Ahep-Phe-Trp-Lys-Bzl-Thr)-

Somatostatin Antagonist

cyclo-(7-ahep-phe-trp-lys-bzl-thr)-somatostati

Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt

Cyclo[7-aminoheptanoyl-L-phenylalanyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-threonyl]

Cyclosomatostatin, Somatostatin antagonist.

84211-54-1

C44H57N7O6

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