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CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])

Product Name
CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])
CAS No.
84211-54-1
Chemical Name
CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])
Synonyms
CYCLO-SOMATOSTATIN;Somatostatin Antagonist;C[AMINOHEPTANOYL-PHE-DTRP-LYS-THR(BZL)];cyclo-(7-ahep-phe-trp-lys-bzl-thr)-somatostati;CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]);somatostatin, cyclo-(7-Ahep-Phe-Trp-Lys-Bzl-Thr)-;Cyclo[7-aminoheptanoyl-L-phenylalanyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-threonyl];Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt
CBNumber
CB0683928
Molecular Formula
C44H57N7O6
Formula Weight
779.97
MOL File
84211-54-1.mol
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CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Property

Boiling point:
1118.4±65.0 °C(Predicted)
Density 
1.147±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: 1 mg/mL, clear, colorless
form 
powder
pka
12.83±0.70(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C4801
Product name
Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl])
Purity
≥95% (HPLC), powder
Packaging
1mg
Price
$360
Updated
2024/03/01
TRC
Product number
C990125
Product name
Cyclosomatostatin
Packaging
5mg
Price
$470
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC108684
Product name
Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt
Packaging
1mg
Price
$131
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC108684
Product name
Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt
Packaging
2mg
Price
$228
Updated
2021/12/16
ApexBio Technology
Product number
B7411
Product name
Cyclosomatostatin
Packaging
1mg
Price
$282
Updated
2021/12/16
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CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Chemical Properties,Usage,Production

Uses

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) has been used as a somatostatin antagonist to study its effects on sleep in rats to infer the role of endogenous somatostatin in the physiologic modulation of REM sleep (REMS) , as an somatostatin (SST) antagonist to study its effects on elemental-induced intestinal atrophy in rats , as an SST receptor antagonist to eliminate the effect of somatostatin on catecholamine .

Biological Activity

cyclosomatostatin is a non-selective somatostatin receptor antagonist.somatostatin is a regulatory hormone or tissue factor playing an inhibitory role in the normal regulation of several organ systems including hypothalamus and pituitary gland, central nervous system, gastrointestinal tract as well as pancreas.

Biochem/physiol Actions

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) (cSSTA) is a cyclic somatostatin (SST) analog and is a somatostatin receptor antagonist. It is involved in blocking the effect of somatostatin, such as airway β-adrenergic function and regulation of acetylcholine release. cSSTA is also involved in blocking the effect of somatostatin of hormone release and?corticotropin-releasing factor-induced suppression of gastric emptying.

in vitro

although cyclosomatostatin could fully block the effect of somatostatin, it only partially reversed the inhibitory effect of cortistatin, a new anti-inflammatory peptide. this observation was further supported by the fact that cyclosomatostatin reversed the antiinfl ammatory effect of somatostatin and octreotide in vitro completely, while only partially reversing the effect of cortistatin [1].

in vivo

the effect of cortistatin was found to be dose dependent, with dose as low as 0.5 nmol (50 μg/kg) being partially protective. in contrast, cyclosomatostatin, somatostatin as well as octreotide were not protective [1].

storage

Store at -20°C

References

[1] gonzalez-rey e,chorny a,robledo g,delgado m. cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia. j exp med.2006 mar 20;203(3):563-71.

CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
967
Advantage
59
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
Advantage
60
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
Alpha Biopharmaceuticals Co., Ltd
Tel
+86-15542445688
Fax
0086-411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
992
Advantage
58
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View Lastest Price from CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) manufacturers

Career Henan Chemical Co
Product
CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) 84211-54-1
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-03-05

84211-54-1, CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])Related Search:


  • CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])
  • CYCLO-SOMATOSTATIN
  • C[AMINOHEPTANOYL-PHE-DTRP-LYS-THR(BZL)]
  • somatostatin, cyclo-(7-Ahep-Phe-Trp-Lys-Bzl-Thr)-
  • Somatostatin Antagonist
  • cyclo-(7-ahep-phe-trp-lys-bzl-thr)-somatostati
  • Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt
  • Cyclo[7-aminoheptanoyl-L-phenylalanyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-threonyl]
  • 84211-54-1
  • C44H57N7O6
  • Somatostatins
  • Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Amino Acids and Peptides