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LIPOXIN A4

Product Name
LIPOXIN A4
CAS No.
89663-86-5
Chemical Name
LIPOXIN A4
Synonyms
LXA;LXA4;LIPOXIN A;LIPOXIN A4;LXA4, CID5280914;5(S),6(R)-LIPOXIN A4;5(S),6(R),15(S)-TRIHETE;Lipoxin A4 MaxSpecStandard;IXAQOQZEOGMIQS-SSQFXEBMSA-N;Lipoxin A - CAS 89663-86-5 - Calbiochem
CBNumber
CB0687274
Molecular Formula
C20H32O5
Formula Weight
352.47
MOL File
89663-86-5.mol
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LIPOXIN A4 Property

Boiling point:
589.4±50.0 °C(Predicted)
Density 
1.096±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
A solution in ethanol, can isomerize and degrade when put into freeze thaw conditions or in solvents such as DMSO, or DMF, 50 mg/ml in Ethanol, 1 mg/ml in PBS (pH 7.2)
form 
ethanol solution
pka
4.67±0.10(Predicted)
color 
Colorless to light yellow
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Safety

Hazard Codes 
F
Risk Statements 
11
Safety Statements 
7-16
RIDADR 
UN 1170 3/PG 2
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L0521
Product name
Lipoxin A4
Purity
ethanol solution
Packaging
25μg
Price
$1110
Updated
2024/03/01
Sigma-Aldrich
Product number
437720
Product name
Lipoxin A₄ - CAS 89663-86-5 - Calbiochem
Purity
Lipoxin A?, CAS 89663-86-5, is a potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides.
Packaging
25μG
Price
$420
Updated
2024/03/01
Cayman Chemical
Product number
90410
Product name
Lipoxin A4
Purity
≥95%
Packaging
25μg
Price
$201
Updated
2024/03/01
Cayman Chemical
Product number
10007271
Product name
Lipoxin A4 MaxSpec? Standard
Purity
≥95%
Packaging
10μg
Price
$242
Updated
2023/01/06
Cayman Chemical
Product number
90410
Product name
Lipoxin A4
Purity
≥95%
Packaging
50μg
Price
$382
Updated
2024/03/01
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LIPOXIN A4 Chemical Properties,Usage,Production

Description

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (LTB4; Item Nos. 10007240 | 20110) in inducing superoxide generation in human neutrophils at 0.1 μM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.

LXA4 MaxSpec® standard is a quantitative grade standard of LXA4 that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LXA4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion. Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.

Uses

Lipoxin A4 is a trihydroxy fatty acid produced through 15-HETE metabolism.

Definition

ChEBI: A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-doubl bonds.

General Description

Caution! Product contains volatile liquid. Keep product cold at all times.

Biochem/physiol Actions

Lipoxin A4 (LXA4) is synthesized from arachidonic acid and is an endogenous lipoxygenase-derived eicosanoid mediator. It is a potent human protein kinase C activator. It inhibits cytotoxicity of natural killer cells. LXA4 regulates the immune system and inflammation. In the brain, it modulates neuronal signaling and slow wave sleep. LXA4 binds to cannabinoid receptors. LXA4 plays a key role in the maintenance of endometrium and reproductive function. Depletion of LXA4 contributes to the pathophysiology of cystic fibrosis (CF).

LIPOXIN A4 Preparation Products And Raw materials

Raw materials

Preparation Products

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LIPOXIN A4 Suppliers

CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82

89663-86-5, LIPOXIN A4Related Search:


  • LIPOXIN A
  • LIPOXIN A4
  • LXA
  • LXA4
  • 5(S),6(R),15(S)-TRIHETE
  • [5S,6R,15S]-TRIHYDROXY-[7E,9E,11Z,13E]-EICOSATETRAENOIC ACID
  • 5(S),6(R),15(S)-TRIHYDROXYEICOSA-7E,9E,11Z,13E-TETRAENOIC ACID
  • 5(S), 6(R), 15(S)-TRIHYDROXYEICOSA-7-TRANS-9-TRANS-11-CIS-13-TRANS-TETRAENOIC ACID
  • 5(S),6(R)-LIPOXIN A4
  • (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
  • (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-Trihydroxy-7,9,11,13-icosatetraenoic acid
  • 5(S),6(R)-Lipoxin A4 Lipid Maps MS Standard
  • LXA4, CID5280914
  • IXAQOQZEOGMIQS-SSQFXEBMSA-N
  • Lipoxin A4 MaxSpecStandard
  • Lipoxin A - CAS 89663-86-5 - Calbiochem
  • 7,9,11,13-Eicosatetraenoic acid, 5,6,15-trihydroxy-, (5S,6R,7E,9E,11Z,13E,15S)-
  • 5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoic acid
  • 89663-86-5
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Protein Kinase C (PKC)
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Activators