ChemicalBook > CAS DataBase List > Z-ASP-OME

Z-ASP-OME

Product Name
Z-ASP-OME
CAS No.
4668-42-2
Chemical Name
Z-ASP-OME
Synonyms
Z-ASP-OME;CBZ-ASP-OME;Z-L-ASP-OME;Cbz-L-Asp-OMe;Z-ASPARTIC ACID-OME;Z-ASP-OME USP/EP/BP;1-Methyl N-Cbz-L-aspartate;Z-L-ASPARTIC ACID A-METHYLESTER;Z-L-ASPARTIC ACID 1-METHYL ESTER;Cbz -L-asparticacidα-methylester
CBNumber
CB0698108
Molecular Formula
C13H15NO6
Formula Weight
281.26
MOL File
4668-42-2.mol
More
Less

Z-ASP-OME Property

Melting point:
89.0 to 93.0 °C
Boiling point:
498.9±45.0 °C(Predicted)
Density 
1.304±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
4.09±0.19(Predicted)
color 
White to Almost white
BRN 
4813538
CAS DataBase Reference
4668-42-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/22-37-41
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29224999
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
95998
Product name
Z-Asp-OMe
Purity
≥98.0% (TLC)
Packaging
5g
Price
$415
Updated
2023/06/20
TCI Chemical
Product number
M2707
Product name
1-Methyl N-Carbobenzoxy-L-aspartate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$99
Updated
2025/07/31
TCI Chemical
Product number
M2707
Product name
1-Methyl N-Carbobenzoxy-L-aspartate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$390
Updated
2025/07/31
TRC
Product number
C227948
Product name
N-Cbz-L-AsparticAcid1-MethylEster
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C227948
Product name
N-Cbz-L-AsparticAcid1-MethylEster
Packaging
500mg
Price
$75
Updated
2021/12/16
More
Less

Z-ASP-OME Chemical Properties,Usage,Production

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

4515-23-5

4668-42-2

The general procedure for the synthesis of (S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid from methanol and Z-aspartic anhydride was as follows: 49.0 g (196 mmol) of benzyl (S)-(2,5-dioxo-tetrahydrofuran-3-yl)carbamate obtained from Steps 1-1 (2) was dissolved in 100 mL of ethyl acetate, followed by adding 150 mL of methanol and the reaction was stirred at room temperature for 5 hours. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure and the resulting residue was dissolved in 200 mL of diisopropyl ether. 34 mL of dicyclohexylamine was added slowly and dropwise with stirring to produce (S)-3-((benzyloxycarbonyl)amino)-4-methoxy-4-oxobutanoic acid dicyclohexylamine salt. The salt was collected by filtration and suspended in 200 mL of distilled water. 200 mL of ethyl acetate was added and the pH was adjusted with 6N hydrochloric acid to 2. After phase separation was carried out, the organic layer was washed several times with distilled water, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. To the concentrated residue 200 mL of diethyl ether and 20 mL of petroleum ether were added to promote crystallization. The resulting crystals were filtered to give 32.3 g of (S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid in 54% yield. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.37 (m, 5H), 5.76 (d, 1H), 5.13 (s, 1H), 4.65 (m, 1H), 3.76 (s, 2H), 3.00 (dd, 2H).

References

[1] Patent: WO2012/148246, 2012, A2. Location in patent: Page/Page column 13

Z-ASP-OME Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Z-ASP-OME Suppliers

Americas 1 China 157 Europe 1 Germany 5 India 7 Japan 3 Switzerland 2 United Kingdom 7 United States 22 Global 205
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7782
Advantage
58
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Sichuan Ampebiochem Co., Ltd.
Tel
028-65294243 13981822079;18682730901
Email
sales@ampebiochem.com
Country
China
ProdList
1000
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Nanjing Derno Pharmaceutical Technology Co., Ltd.
Tel
025-86957866 13952093866
Fax
025-68661287
Email
sales@dernopharm.com
Country
China
ProdList
932
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Chengdu Chuangkecheng Biological Technology Co., Ltd.
Tel
028-028-0000000 13008177686
Fax
15928581901
Email
sales@ckcbiotech.com
Country
China
ProdList
904
Advantage
55
Changzhou Anxuan Chemical, Co., Ltd.
Tel
13912302692 13912302692;
Fax
0519-88064678
Email
sales@anxuanchem.com
Country
China
ProdList
4828
Advantage
58
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
CHMA Chemical Technology (Shanghai) Co., Ltd
Tel
021-61556450 15800904410
Fax
021-61556450
Country
China
ProdList
2832
Advantage
58
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9942
Advantage
58
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13305
Advantage
58
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Sichuan Lancent Medical Devices Co., Ltd.
Tel
18111675298
Fax
-
Email
stochem@aliyun.com
Country
China
ProdList
212
Advantage
58
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.
Tel
028-85755578 18140172005
Fax
028-85755578
Email
sales@aminotp.com
Country
China
ProdList
298
Advantage
58
Sichuan jiayinglai technology CO.,LTD
Tel
028-028-88457210 18190964009
Fax
QQ3213375147
Email
3054240163@qq.com
Country
China
ProdList
2293
Advantage
55
JinJin Le Chemical Co., Ltd
Tel
18001959627(微信同号) 18001959627
Email
jjlchem2@163.com
Country
China
ProdList
9981
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
10007
Advantage
58
Shanghai BaiShun Biological Technology Co., Ltd
Tel
021-37581181
Fax
021-57456066
Email
sales@chem-mall.com
Country
China
ProdList
10330
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
More
Less

View Lastest Price from Z-ASP-OME manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Z-ASP-OME 4668-42-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
Z-ASP-OME 4668-42-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2019-08-31

4668-42-2, Z-ASP-OMERelated Search:

Z-ASP(OME)-OH,CBZ-ASP(OME)-OH N-Carbobenzyloxy-L-aspartic acid N-Benzyloxycarbonyl-L-asparagine N-Cbz-L-Aspartic acid 4-tert-butyl ester Z-ASP-OBZL Z-DEVD-CMK Z-Asp(OtBu)-OH·H2O Z-Asp(OtBu)-Glu(OtBu)-OH Z-ASP(OBZL)-OSU N-Cbz-L-Aspartic acid 4-benzyl ester Z-ASP(OTBU)-BROMOMETHYLKETONE Z-ASP(OTBU)-OH DCHA Z-Asp(OtBu)-His(Trt)-OH Z-ASP(OTBU)-OSU Z-Asp(OMe)-OtBu Z-TLE-OH DCHA Z-L-METHIONINE METHYL ESTER Z-TRP-ONP

  • N-BENZYLOXYCARBONYL-L-ASPARTIC ACID 1-METHYL ESTER
  • N-ALPHA-BENZYLOXYCARBONYL-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • N-CBZ-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • Z-L-ASP-OME
  • Z-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • Z-L-ASPARTIC ACID 1-METHYL ESTER
  • Z-ASPARTIC ACID-OME
  • Z-ASP-OME
  • CBZ-ASP-OME
  • CBZ-L-ASPARTIC ACID 1-METHYL ESTER
  • CBZ-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • N-Cbz-L-aspartic acid α-methyl ester
  • N-Benzyloxycarbonylaspartic acid 1-Methyl ester
  • 1-Methyl N-Carbobenzoxy-L-aspartate
  • Cbz-L-Asp-OMe
  • Z-L-aspartic acid α-methyl ester99%
  • N-ALPHA-CARBOBENZOXY-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • N-CBZ-L-ASPARTIC ACID A-METHYL ESTER
  • Cbz -L-asparticacidα-methylester
  • Z-L-ASPARTIC ACID A-METHYLESTER
  • N-Carbobenzyloxy-L-aspartic acid methyl ester
  • N-carbobenzyloxy-L-aspartic acid alpha-methyl ester
  • N-Cbz-L-aspartic acid α-methyl ester, Z-L-Aspartic acid 1-methyl ester
  • (S)-3-(Benzyloxycarbonylamino)-4-methoxy-4-oxobutanoic acid
  • N-Cbz-L-Aspartic acid 1-methyl ester
  • (3S)-3-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoic acid
  • 1-Methyl N-Carbobenzoxy-L-aspartate &gt
  • (3S)-4-methoxy-4-oxo-3-(phenylmethoxycarbonylamino)butanoicaci
  • 1-Methyl N-Benzyloxycarbonyl-L-aspartate
  • 1-Methyl N-Cbz-L-aspartate
  • N-Carbobenzoxy-L-aspartic Acid 1-Methyl Ester
  • Z-ASP-OME USP/EP/BP
  • Z-L-aspartic acid α-methyl ester
  • (3S)-4-methoxy-4-oxo-3-(phenylmethoxycarbonylamino)butanoic acid
  • N-Cbz-L-Aspatric AcidMmethyl Ester
  • 4668-42-2
  • HO2CCH2CHNHCO2CH2C6H5CO2CH3
  • CARBOXYLIC ACID
  • Amino Acid Derivatives
  • Aspartic Acid
  • Specialty Synthesis
  • Peptide Synthesis
  • Aspartic acid [Asp, D]
  • Z-Amino Acids and Derivatives
  • Z-Amino acid series
  • Amino Acid Derivatives