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Z-ASP-OME

Product Name
Z-ASP-OME
CAS No.
4668-42-2
Chemical Name
Z-ASP-OME
Synonyms
Z-ASP-OME;CBZ-ASP-OME;Z-L-ASP-OME;Cbz-L-Asp-OMe;Z-ASPARTIC ACID-OME;Z-ASP-OME USP/EP/BP;1-Methyl N-Cbz-L-aspartate;Z-L-ASPARTIC ACID A-METHYLESTER;Z-L-ASPARTIC ACID 1-METHYL ESTER;Cbz -L-asparticacidα-methylester
CBNumber
CB0698108
Molecular Formula
C13H15NO6
Formula Weight
281.26
MOL File
4668-42-2.mol
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Z-ASP-OME Property

Melting point:
89.0 to 93.0 °C
Boiling point:
498.9±45.0 °C(Predicted)
Density 
1.304±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
4.09±0.19(Predicted)
color 
White to Almost white
BRN 
4813538
CAS DataBase Reference
4668-42-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/22-37-41
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
95998
Product name
Z-Asp-OMe
Purity
≥98.0% (TLC)
Packaging
5g
Price
$415
Updated
2023/06/20
TCI Chemical
Product number
M2707
Product name
1-Methyl N-Carbobenzoxy-L-aspartate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$99
Updated
2025/07/31
TCI Chemical
Product number
M2707
Product name
1-Methyl N-Carbobenzoxy-L-aspartate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$390
Updated
2025/07/31
TRC
Product number
C227948
Product name
N-Cbz-L-AsparticAcid1-MethylEster
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C227948
Product name
N-Cbz-L-AsparticAcid1-MethylEster
Packaging
500mg
Price
$75
Updated
2021/12/16
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Z-ASP-OME Chemical Properties,Usage,Production

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

4515-23-5

4668-42-2

The general procedure for the synthesis of (S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid from methanol and Z-aspartic anhydride was as follows: 49.0 g (196 mmol) of benzyl (S)-(2,5-dioxo-tetrahydrofuran-3-yl)carbamate obtained from Steps 1-1 (2) was dissolved in 100 mL of ethyl acetate, followed by adding 150 mL of methanol and the reaction was stirred at room temperature for 5 hours. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure and the resulting residue was dissolved in 200 mL of diisopropyl ether. 34 mL of dicyclohexylamine was added slowly and dropwise with stirring to produce (S)-3-((benzyloxycarbonyl)amino)-4-methoxy-4-oxobutanoic acid dicyclohexylamine salt. The salt was collected by filtration and suspended in 200 mL of distilled water. 200 mL of ethyl acetate was added and the pH was adjusted with 6N hydrochloric acid to 2. After phase separation was carried out, the organic layer was washed several times with distilled water, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. To the concentrated residue 200 mL of diethyl ether and 20 mL of petroleum ether were added to promote crystallization. The resulting crystals were filtered to give 32.3 g of (S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid in 54% yield. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.37 (m, 5H), 5.76 (d, 1H), 5.13 (s, 1H), 4.65 (m, 1H), 3.76 (s, 2H), 3.00 (dd, 2H).

References

[1] Patent: WO2012/148246, 2012, A2. Location in patent: Page/Page column 13

Z-ASP-OME Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-ASP-OME Suppliers

Americas 1 China 157 Europe 1 Germany 5 India 7 Japan 3 Switzerland 2 United Kingdom 7 United States 22 Global 205
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
chemcube
Tel
--
Fax
--
Email
sales@chemcube.eu
Country
Germany
ProdList
4083
Advantage
34
IRIS Biotech GmbH
Tel
--
Fax
--
Country
Germany
ProdList
4426
Advantage
68
PARAGOS
Tel
--
Fax
--
Email
info@paragos.com
Country
Germany
ProdList
6371
Advantage
39
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from Z-ASP-OME manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Z-ASP-OME 4668-42-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
Z-ASP-OME 4668-42-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2019-08-31

4668-42-2, Z-ASP-OMERelated Search:

Z-ASP(OME)-OH,CBZ-ASP(OME)-OH N-Carbobenzyloxy-L-aspartic acid N-Benzyloxycarbonyl-L-asparagine N-Cbz-L-Aspartic acid 4-tert-butyl ester Z-ASP-OBZL Z-DEVD-CMK Z-Asp(OtBu)-OH·H2O Z-Asp(OtBu)-Glu(OtBu)-OH Z-ASP(OBZL)-OSU N-Cbz-L-Aspartic acid 4-benzyl ester Z-ASP(OTBU)-BROMOMETHYLKETONE Z-ASP(OTBU)-OH DCHA Z-Asp(OtBu)-His(Trt)-OH Z-ASP(OTBU)-OSU Z-Asp(OMe)-OtBu Z-TLE-OH DCHA Z-L-METHIONINE METHYL ESTER Z-TRP-ONP

  • N-BENZYLOXYCARBONYL-L-ASPARTIC ACID 1-METHYL ESTER
  • N-ALPHA-BENZYLOXYCARBONYL-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • N-CBZ-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • Z-L-ASP-OME
  • Z-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • Z-L-ASPARTIC ACID 1-METHYL ESTER
  • Z-ASPARTIC ACID-OME
  • Z-ASP-OME
  • CBZ-ASP-OME
  • CBZ-L-ASPARTIC ACID 1-METHYL ESTER
  • CBZ-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • N-Cbz-L-aspartic acid α-methyl ester
  • N-Benzyloxycarbonylaspartic acid 1-Methyl ester
  • 1-Methyl N-Carbobenzoxy-L-aspartate
  • Cbz-L-Asp-OMe
  • Z-L-aspartic acid α-methyl ester99%
  • N-ALPHA-CARBOBENZOXY-L-ASPARTIC ACID ALPHA-METHYL ESTER
  • N-CBZ-L-ASPARTIC ACID A-METHYL ESTER
  • Cbz -L-asparticacidα-methylester
  • Z-L-ASPARTIC ACID A-METHYLESTER
  • N-Carbobenzyloxy-L-aspartic acid methyl ester
  • N-carbobenzyloxy-L-aspartic acid alpha-methyl ester
  • N-Cbz-L-aspartic acid α-methyl ester, Z-L-Aspartic acid 1-methyl ester
  • (S)-3-(Benzyloxycarbonylamino)-4-methoxy-4-oxobutanoic acid
  • N-Cbz-L-Aspartic acid 1-methyl ester
  • (3S)-3-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoic acid
  • 1-Methyl N-Carbobenzoxy-L-aspartate &gt
  • (3S)-4-methoxy-4-oxo-3-(phenylmethoxycarbonylamino)butanoicaci
  • 1-Methyl N-Benzyloxycarbonyl-L-aspartate
  • 1-Methyl N-Cbz-L-aspartate
  • N-Carbobenzoxy-L-aspartic Acid 1-Methyl Ester
  • Z-ASP-OME USP/EP/BP
  • Z-L-aspartic acid α-methyl ester
  • (3S)-4-methoxy-4-oxo-3-(phenylmethoxycarbonylamino)butanoic acid
  • N-Cbz-L-Aspatric AcidMmethyl Ester
  • 4668-42-2
  • HO2CCH2CHNHCO2CH2C6H5CO2CH3
  • CARBOXYLIC ACID
  • Amino Acid Derivatives
  • Aspartic Acid
  • Specialty Synthesis
  • Peptide Synthesis
  • Aspartic acid [Asp, D]
  • Z-Amino Acids and Derivatives
  • Z-Amino acid series
  • Amino Acid Derivatives