LIPOXIN B4 Property

storage temp. 

-20°C

solubility 

DMF: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml (from 13(S)-HODE)

Safety

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

LIPOXIN B4 Chemical Properties,Usage,Production

Uses

Lipoxins are a series of anti-inflammatory lipid mediators whose brief appearance generally signals the resolution of inflammation. Lipoxin A4 (LXA4) is a potent inhibitor of leukotriene (LT)-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interaction and also blocks PMN migration stimulated by LTB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 10-7 M, LXB4 inhibits PMN migration stimulated by LTB4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of ~3 X 10-10 M.

Uses

5(S),14(R)-Lipoxin B4 is a positional isomer of LXA4.

Definition

ChEBI: Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds. It has a role as a human metabolite. It is a lipoxin, a long-chain fatty acid and a hydroxy polyunsaturated fatty acid. It is a conjugate acid of a lipoxin B4(1-).