METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE

Product Name: METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
CAS No.: 89524-99-2
Chemical Name: METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
Synonyms: Ac-Gly(PO(OMe)2-OMe;Ac-α-phosphonoglycine trimethyl ester;Trimethyl α-(Acetamido)phosphonoacetate;Trimethyl Alpha-(Acetamido)phosphonoacetate;methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate;methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate;METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE;Methyl alpha-(acetylamino)-alpha-(dimethoxyphosphoryl)acetate;Acetic acid, (acetylaMino)(diMethoxyphosphinyl)-, Methyl ester;Acetic acid,2-(acetylaMino)-2-(diMethoxyphosphinyl)-, Methyl ester
CBNumber: CB0708892
Molecular Formula: C7H14NO6P
Formula Weight: 239.16
MOL File: 89524-99-2.mol

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METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Property

Melting point:: 88.0-88.5℃
Boiling point:: 385.3±32.0 °C(Predicted)
Density: 1.253±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 13.20±0.46(Predicted)
color: White to Off-White
InChI: InChI=1S/C7H14NO6P/c1-5(9)8-6(7(10)12-2)15(11,13-3)14-4/h6H,1-4H3,(H,8,9)
InChIKey: MXNIODZSMNMILW-UHFFFAOYSA-N
SMILES: C(OC)(=O)C(NC(C)=O)P(OC)(OC)=O

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Safety

HazardClass: IRRITANT
HS Code: 2915390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M219250
Product name: Trimethylα-(Acetamido)phosphonoacetate
Packaging: 50mg
Price: $50
Updated: 2021/12/16

TRC

Product number: M219250
Product name: Trimethylα-(Acetamido)phosphonoacetate
Packaging: 100mg
Price: $70
Updated: 2021/12/16

Ark Pharm

Product number: AK481306
Product name: Methyl2-acetamido-2-(dimethoxyphosphoryl)acetate
Purity: 97%
Packaging: 5g
Price: $105
Updated: 2021/12/16

Ark Pharm

Product number: AK481306
Product name: Methyl2-acetamido-2-(dimethoxyphosphoryl)acetate
Purity: 97%
Packaging: 250mg
Price: $18
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8177-1-14
Product name: Methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate
Packaging: 1g
Price: $128
Updated: 2021/12/16

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METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Chemical Properties,Usage,Production

Uses

Trimethyl α-(Acetamido)phosphonoacetate can be prepared to use as HDAC inhibitor to treat cell proliferative diseases, autoimmune diseases, inflammation, neurodegenerative diseases or viral diseases.

Synthesis

108-24-7

100945-15-1

89524-99-2

GENERAL STEPS: Compound C152 (12.65 g, 38.2 mmol) and acetic anhydride (9.02 mL, 95.5 mmol) were dissolved in methanol (100 mL), and the mixed solution was transferred to a Parr autoclave. 10% Pd/C catalyst (0.640 g) was added and the hydrogenation reaction was carried out at 45 psi hydrogen pressure for 3 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give an oil. The oil was placed in a depressurized environment and reduced pressure was applied to solidify it. The resulting white solid was dissolved in a small amount of ethyl acetate and pentane was slowly added with vigorous stirring until a precipitate began to form. The precipitate was separated by filtration to give methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate (C153) as a white powder in 87% yield. Mass spectrometry (chemical ionization, CI) analysis showed a molecular ion peak (M+H)+ m/z of 240 for C7H14NO6P.

References

[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 8, p. 1277 - 1286
[2] Synthesis, 1984, # 1, p. 53 - 60
[3] Organic Syntheses, 2011, vol. 88, p. 152 - 161
[4] Tetrahedron, 2007, vol. 63, # 51, p. 12740 - 12746
[5] Patent: WO2004/39815, 2004, A2. Location in patent: Page 52 - 53

METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Suppliers

Canada 1 China 58 India 2 United Kingdom 2 United States 8 Global 71

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View Lastest Price from METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: methyl 2-acetamido-2-dimethoxyphosphorylacetate 89524-99-2
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE 89524-99-2
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 98
Supply Ability: 100kg
Release date: 2023-03-22

Hebei Mingeng Biotechnology Co., Ltd

Product: methyl 2-acetamido-2-dimethoxyphosphorylacetate 89524-99-2
Price: US $200.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 500kg/month
Release date: 2022-05-05

89524-99-2, METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATERelated Search:

ETHYL 2-[(2-CHLOROBENZOYL)AMINO]-2-(DIISOPROPOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE METHYL 2-(BENZOYLAMINO)-2-(DIETHOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-(BENZOYLAMINO)-2-(DIETHOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE METHYL 2-(BENZOYLAMINO)-2-(DIISOPROPOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-(BENZOYLAMINO)-2-(DIISOPROPOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE

methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate

Acetic acid, (acetylaMino)(diMethoxyphosphinyl)-, Methyl ester

METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE

Methyl alpha-(acetylamino)-alpha-(dimethoxyphosphoryl)acetate

Acetic acid,2-(acetylaMino)-2-(diMethoxyphosphinyl)-, Methyl ester

Ac-Gly(PO(OMe)2-OMe

Ac-α-phosphonoglycine trimethyl ester

Trimethyl α-(Acetamido)phosphonoacetate

methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate

Trimethyl Alpha-(Acetamido)phosphonoacetate

89524-99-2

C7H14NO6P