ChemicalBook > CAS DataBase List > METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE

METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE

Product Name
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
CAS No.
89524-99-2
Chemical Name
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
Synonyms
Ac-Gly(PO(OMe)2-OMe;Ac-α-phosphonoglycine trimethyl ester;Trimethyl α-(Acetamido)phosphonoacetate;Trimethyl Alpha-(Acetamido)phosphonoacetate;methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate;methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate;METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE;Methyl alpha-(acetylamino)-alpha-(dimethoxyphosphoryl)acetate;Acetic acid, (acetylaMino)(diMethoxyphosphinyl)-, Methyl ester;Acetic acid,2-(acetylaMino)-2-(diMethoxyphosphinyl)-, Methyl ester
CBNumber
CB0708892
Molecular Formula
C7H14NO6P
Formula Weight
239.16
MOL File
89524-99-2.mol
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METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Property

Melting point:
88.0-88.5℃
Boiling point:
385.3±32.0 °C(Predicted)
Density 
1.253±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
13.20±0.46(Predicted)
color 
White to Off-White
InChI
InChI=1S/C7H14NO6P/c1-5(9)8-6(7(10)12-2)15(11,13-3)14-4/h6H,1-4H3,(H,8,9)
InChIKey
MXNIODZSMNMILW-UHFFFAOYSA-N
SMILES
C(OC)(=O)C(NC(C)=O)P(OC)(OC)=O
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Safety

HazardClass 
IRRITANT
HS Code 
2915390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M219250
Product name
Trimethylα-(Acetamido)phosphonoacetate
Packaging
50mg
Price
$50
Updated
2021/12/16
TRC
Product number
M219250
Product name
Trimethylα-(Acetamido)phosphonoacetate
Packaging
100mg
Price
$70
Updated
2021/12/16
Ark Pharm
Product number
AK481306
Product name
Methyl2-acetamido-2-(dimethoxyphosphoryl)acetate
Purity
97%
Packaging
5g
Price
$105
Updated
2021/12/16
Ark Pharm
Product number
AK481306
Product name
Methyl2-acetamido-2-(dimethoxyphosphoryl)acetate
Purity
97%
Packaging
250mg
Price
$18
Updated
2021/12/16
SynQuest Laboratories
Product number
8177-1-14
Product name
Methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate
Packaging
1g
Price
$128
Updated
2021/12/16
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METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Chemical Properties,Usage,Production

Uses

Trimethyl α-(Acetamido)phosphonoacetate can be prepared to use as HDAC inhibitor to treat cell proliferative diseases, autoimmune diseases, inflammation, neurodegenerative diseases or viral diseases.

Synthesis

108-24-7

100945-15-1

89524-99-2

GENERAL STEPS: Compound C152 (12.65 g, 38.2 mmol) and acetic anhydride (9.02 mL, 95.5 mmol) were dissolved in methanol (100 mL), and the mixed solution was transferred to a Parr autoclave. 10% Pd/C catalyst (0.640 g) was added and the hydrogenation reaction was carried out at 45 psi hydrogen pressure for 3 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give an oil. The oil was placed in a depressurized environment and reduced pressure was applied to solidify it. The resulting white solid was dissolved in a small amount of ethyl acetate and pentane was slowly added with vigorous stirring until a precipitate began to form. The precipitate was separated by filtration to give methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate (C153) as a white powder in 87% yield. Mass spectrometry (chemical ionization, CI) analysis showed a molecular ion peak (M+H)+ m/z of 240 for C7H14NO6P.

References

[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 8, p. 1277 - 1286
[2] Synthesis, 1984, # 1, p. 53 - 60
[3] Organic Syntheses, 2011, vol. 88, p. 152 - 161
[4] Tetrahedron, 2007, vol. 63, # 51, p. 12740 - 12746
[5] Patent: WO2004/39815, 2004, A2. Location in patent: Page 52 - 53

METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
methyl 2-acetamido-2-dimethoxyphosphorylacetate 89524-99-2
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE 89524-99-2
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
98
Supply Ability
100kg
Release date
2023-03-22
Hebei Mingeng Biotechnology Co., Ltd
Product
methyl 2-acetamido-2-dimethoxyphosphorylacetate 89524-99-2
Price
US $200.00/kg
Min. Order
10kg
Purity
99%
Supply Ability
500kg/month
Release date
2022-05-05

89524-99-2, METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATERelated Search:

ETHYL 2-[(2-CHLOROBENZOYL)AMINO]-2-(DIISOPROPOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE METHYL 2-(BENZOYLAMINO)-2-(DIETHOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-(BENZOYLAMINO)-2-(DIETHOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE METHYL 2-(BENZOYLAMINO)-2-(DIISOPROPOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-(BENZOYLAMINO)-2-(DIISOPROPOXYPHOSPHORYL)-3,3,3-TRIFLUOROPROPANOATE

  • methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate
  • Acetic acid, (acetylaMino)(diMethoxyphosphinyl)-, Methyl ester
  • METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
  • Methyl alpha-(acetylamino)-alpha-(dimethoxyphosphoryl)acetate
  • Acetic acid,2-(acetylaMino)-2-(diMethoxyphosphinyl)-, Methyl ester
  • Ac-Gly(PO(OMe)2-OMe
  • Ac-α-phosphonoglycine trimethyl ester
  • Trimethyl α-(Acetamido)phosphonoacetate
  • methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate
  • Trimethyl Alpha-(Acetamido)phosphonoacetate
  • 89524-99-2
  • C7H14NO6P