Diethyl 2-propylImidazoledicarbonate

Uses

Product Name: Diethyl 2-propylImidazoledicarbonate
CAS No.: 144689-94-1
Chemical Name: Diethyl 2-propylImidazoledicarbonate
Synonyms: OMSTint-C;Olmesartan Impurity 17;2-propyl-, diethyl ester;Intermediate of olmesartan;carbonic acid carboxy ester;4,5-diethyl-2-propyl-1H-imidazole;Diethyl 2-propylImidazoledicarbote;2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYL;Diethyl 2-propylImidazoledicarbonate;OlMesartan IMidazole Diethyl Ester IMpurity
CBNumber: CB0712929
Molecular Formula: C12H18N2O4
Formula Weight: 254.28
MOL File: 144689-94-1.mol

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Diethyl 2-propylImidazoledicarbonate Property

Melting point:: 86 °C
Boiling point:: 400.9±25.0 °C(Predicted)
Density: 1.160±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
pka: 9.25±0.10(Predicted)
color: White to Yellow to Orange
CAS DataBase Reference: 144689-94-1(CAS DataBase Reference)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3765
Product name: Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: D3765
Product name: Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $164
Updated: 2025/07/31

TRC

Product number: D444795
Product name: Diethyl-2-propylimidazole-4,5-dicarboxylate
Packaging: 25g
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21814
Product name: Diethyl-2-propylimidazole-4,5-dicarboxylate
Packaging: 5G
Price: $173.6
Updated: 2021/12/16

Apolloscientific

Product number: OR350152
Product name: Diethyl2-Propylimidazole-4,5-dicarboxylate
Packaging: 25g
Price: $174
Updated: 2021/12/16

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Diethyl 2-propylImidazoledicarbonate Chemical Properties,Usage,Production

Uses

Diethyl 2-propylImidazoledicarbonate is an intermediate in the synthesis of Olmesartan Medoxomil.

Chemical Properties

Light Yellow Solid

Uses

An intermediate in the synthesis of Olmesartan Medoxomil. (O550000)

Synthesis

58954-23-7

64-17-5

144689-94-1

General procedure for the synthesis of diethyl 2-propyl-4,5-imidazoledicarboxylate from 2-propyl-1H-imidazole-4,5-dicarboxylic acid and ethanol: 48 mmol of 2-n-propylimidazole-4,5-dicarboxylic acid (synthesized in Example 3) was added to a four-necked flask with 152 mL of ethanol. 20.22 g (165 mmol) of thionyl chloride was added slowly dropwise at liquid temperature over 1 hour and 40 minutes. Subsequently 0.91 g (51 mmol) of water was added and the reaction solution was cooled to room temperature. The reaction mixture was heated to reflux for 5 hours (liquid temperature: 74 °C to room temperature). Upon completion of the reaction, the precipitated inorganic salt was removed by filtration. The filtrate was concentrated and partitioned for extraction by adding 50 mL of ethyl acetate and 60 mL of saturated aqueous sodium bicarbonate. After adjusting the pH of the aqueous layer to 7, 20 mL of ethyl acetate was added. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product of diethyl 2-propyl-4,5-imidazoledicarboxylate. To the crude product, 13.06 g of ethyl acetate and 1.07 g of ethanol were added, concentrated to a product weight of 14.5 g and crystallized. After filtration, it was dried under vacuum at 50°C to obtain diethyl 2-propyl-4,5-imidazoledicarboxylate. The first to third crystals were obtained sequentially by recrystallizing the mother liquor and repeating the recrystallization process according to the same method as in Example 1. By HPLC analysis, the yield was 9.50 g (77%) and the HPLC purity was 99.7% for the first crystal, 99.7% for the second crystal and 99.0% for the third crystal, respectively.

References

[1] Organic Preparations and Procedures International, 2006, vol. 38, # 4, p. 410 - 412
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 323 - 338
[3] Patent: JP5688696, 2015, B2. Location in patent: Paragraph 0097

Diethyl 2-propylImidazoledicarbonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Diethyl 2-propylImidazoledicarbonate Suppliers

Americas 1 Canada 1 China 220 Europe 1 Germany 4 India 37 Japan 1 Ukraine 1 United Kingdom 8 United States 26 Global 300

Wuhan hongde yuexin pharmaceutical technology co. LTD

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Accela ChemBio Co.,Ltd.

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View Lastest Price from Diethyl 2-propylImidazoledicarbonate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Diethyl 2-propylImidazoledicarbonate 144689-94-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-11-19

Henan Aochuang Chemical Co.,Ltd.

Product: Diethyl 2-propylImidazoledicarbonate 144689-94-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Olmesartan Medoxomil Impurity 27 144689-94-1
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-14

144689-94-1, Diethyl 2-propylImidazoledicarbonateRelated Search:

2-Propyl-1H-imidazole-4,5-dicarboxy acid OlMesartan Lactone IMpurity 1-(4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazol-5-yl)ethanone 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester OlMesartan Ethyl Ester IMpurity 3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one Olmesartan medoxomil impurity I Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Trityl olMesartan MedoxoMil iMpurity II OlMesartan Methyl Ester OlMesartan interMediate iMpurity II OlMesartan MedoxoMil Butyl IMpurity Olmesartan Impurity 12 5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole 4,5-Dimethyl-1,3-dioxol-2-one 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid Olmesartan Olmesartan Impurity 10

2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYL

2-Propylimidazoledicarboxylic acid diethyl ester

2-PROPYL-4,5-IMIDAZOLEDICARBOXYLIC ACID DIETHYL ESTER 98.0%

2-propyl-, diethyl ester

1H-Imidazole-4,5-dicarboxylic acid, 2-propyl-, 4,5-diethyl ester

2-proyl-4,5-imidazoledicarboxylic acid diethyl ester

4,5-diethyl 2-propyl-1H-iMidazole-4,5-dicarboxylate

2-Propyl-1H-iMidazole-4,5-dicarboxylic Acid 4,5-Diethyl Ester

OlMesartan IMidazole Diethyl Ester IMpurity

2-Propyl-1H-imidazol-4,5-dicarboxylic acid 4,5-diethyl ester

2-propy-1H-imidazole-4,5-dicarboxylic acid diethyl ester

4,5-diethyl-2-propyl-1H-imidazole

carbonic acid carboxy ester

Diethyl 2-Propyl-1H-Imidazole-4,5-Dicarboxylat

Diethyl 2-Propyl-1<i>H</i>-imidazole-4,5-dicarboxylate

Diethyl 2-propylImidazoledicarbote

2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXY ACID DIETHYL ESTER

2-PROPYL-1H-IMIDAZOLE-4, 5-DICARBOXYLIC ACID DIETHYL ESTER

1H-IMIDAZOLE-4, 5-DICARBOXYLIC ACID,2-PROPYL-DIETHYL ESTER

DIETHYL 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYLATE

Diethyl 2-propylImidazoledicarbonate

2-propyl-1H-imidazole-4,5-dicarboxyaciddiethyl

Olmesartan Impurity 17

OMSTint-C

Diethyl2-Propyl-1H-imidazole-4,5-dicarboxylate&gt

Diethyl 2-propylImidazoledicarbonate USP/EP/BP

Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate Molecular Formula: C12H18N2O4 Molecular Weight: 254.28

Olmesartan Imidazole Diethyl Ester Impurity 2-Propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester

Intermediate of olmesartan

144689-94-1

C12H18O4N2

Aromatics

Intermediates

Organic acids

Pharmaceutical material and intermeidates