HNMPA-(AM)3

Product Name: HNMPA-(AM)3
CAS No.: 120944-03-8
Chemical Name: HNMPA-(AM)3
Synonyms: HNMPA-(AM);HNMPA-(AM)3;PRO-DRUG II;HNMPA-(AM)₃;HYDROXY-2-NAPHTHALENYLMETHYLPHOSPHONIC ACID TRISACETOXYMETHYL ESTER;Phosphonic acid, P-[[(acetyloxy)methoxy]-2-naphthalenylmethyl]-, bis[(acetyloxy)methyl] ester
CBNumber: CB0716361
Molecular Formula: C20H23O10P
Formula Weight: 454.36
MOL File: Mol file

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HNMPA-(AM)3 Property

Boiling point:: 573.1±50.0 °C(Predicted)
Density: 1.325±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 15 mg/ml; DMSO: 1 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 1 mg/ml
form: Colorless oil.
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 397100
Product name: HNMPA-(AM)<SUB>3</SUB>
Purity: A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases.
Packaging: 5 mg
Price: $222
Updated: 2025/07/31

Cayman Chemical

Product number: 23245
Product name: HNMPA-(AM)3
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 23245
Product name: HNMPA-(AM)3
Purity: ≥95%
Packaging: 5mg
Price: $233
Updated: 2024/03/01

Cayman Chemical

Product number: 23245
Product name: HNMPA-(AM)3
Purity: ≥95%
Packaging: 10mg
Price: $441
Updated: 2024/03/01

AK Scientific

Product number: 0423CA
Product name: Hnmpa-(AM)3
Packaging: 1mg
Price: $133
Updated: 2021/12/16

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HNMPA-(AM)3 Chemical Properties,Usage,Production

Uses

HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively)[1][2].

Definition

ChEBI: Hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester is an organic phosphonate that is the trisacetoxymethylester derivative of naphthalene substituted hydroxymethylphosphonic acid. It has been found to inhibit insulin receptor tyrosine kinase activity and insulin stimulated glucose oxidation. It has a role as a tyrosine kinase inhibitor. It is an organic phosphonate, a member of naphthalenes and an acetate ester. It is functionally related to a hydroxymethylphosphonic acid.

Biological Activity

Cell permeable: yes', 'Primary Target
tyrosine kinase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 100 μM and 10 μM against insulin receptor tyrosine kinase and insulin-stimulated glucose oxidation in isolated r at adipocytes, respectively

References

[1] Riehle MA, et al. Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 1999 Oct;29(10):855-60. DOI:10.1016/s0965-1748(99)00084-3
[2] Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca2+/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101. DOI:10.1016/j.jinsphys.2009.09.008

HNMPA-(AM)3 Preparation Products And Raw materials

Raw materials

Preparation Products

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HNMPA-(AM)3 Suppliers

China 38 Japan 1 Switzerland 1 United Kingdom 1 United States 4 Global 45

Shanghai EFE Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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RD International Technology Co., Limited

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Cayman Chemical Company

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Guangzhou Qiansheng Biotechnology Co., Ltd.

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120944-03-8, HNMPA-(AM)3Related Search:

(-)PPP Hydroxy(2-naphthyl)Methanephosphonic Acid

PRO-DRUG II

HYDROXY-2-NAPHTHALENYLMETHYLPHOSPHONIC ACID TRISACETOXYMETHYL ESTER

HNMPA-(AM)

HNMPA-(AM)3

Phosphonic acid, P-[[(acetyloxy)methoxy]-2-naphthalenylmethyl]-, bis[(acetyloxy)methyl] ester

HNMPA-(AM)<sub>3</sub>

120944-03-8