Hydroxy(2-naphthyl)Methanephosphonic Acid
- Product Name
- Hydroxy(2-naphthyl)Methanephosphonic Acid
- CAS No.
- 132541-52-7
- Chemical Name
- Hydroxy(2-naphthyl)Methanephosphonic Acid
- Synonyms
- Hydroxy(2-naphthyl)Methanephosphonic Acid;P-(Hydroxy-2-naphthalenylMethyl)phosphonic Acid;Phosphonic acid, P-(hydroxy-2-naphthalenylmethyl)-;Inhibitor,HNMPA,serine autophosphorylation,tyrosine autophosphorylation,tyrosine kinase,Insulin Receptor,inhibit
- CBNumber
- CB52545214
- Molecular Formula
- C11H11O4P
- Formula Weight
- 238.18
- MOL File
- 132541-52-7.mol
Hydroxy(2-naphthyl)Methanephosphonic Acid Property
- Melting point:
- >180oC(dec.)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO, Methanol
- form
- White solid.
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- J63913
- Product name
- (Hydroxy-2-naphthylmethyl)phosphonic acid
- Purity
- 98%
- Packaging
- 5mg
- Price
- $126.65
- Updated
- 2024/03/01
- Product number
- J63913
- Product name
- (Hydroxy-2-naphthylmethyl)phosphonic acid
- Purity
- 98%
- Packaging
- 25mg
- Price
- $615
- Updated
- 2023/06/20
- Product number
- 15543
- Product name
- HNMPA
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 15543
- Product name
- HNMPA
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 15543
- Product name
- HNMPA
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
Hydroxy(2-naphthyl)Methanephosphonic Acid Chemical Properties,Usage,Production
Description
HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 μM in vitro.
Uses
A selective insulin receptor tyrosine kinase inhibitor
Uses
Insulin receptor tyrosine kinase (IRTK) inhibitor.
References
[1]. baltensperger k, lewis re, woon cw, et al. catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. proc natl acad sci u s a. 1992 sep 1;89(17):7885-9.
[2]. moon mj, kim hy, park s, et al. insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. mol cells. 2011 oct;32(4):389-95.
Hydroxy(2-naphthyl)Methanephosphonic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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