ChemicalBook > CAS DataBase List > CGP 55845

CGP 55845

Product Name
CGP 55845
CAS No.
149184-22-5
Chemical Name
CGP 55845
Synonyms
CGP 55845;CGP 55845 hydrochlor;CGP 55845 hydrochloride;benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;(2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID;(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
CBNumber
CB0718390
Molecular Formula
C18H23Cl3NO3P
Formula Weight
438.71
MOL File
149184-22-5.mol
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CGP 55845 Property

storage temp. 
room temp
solubility 
DMSO: soluble5mg/mL, clear (warmed)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
RTECS 
SZ4680000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0594
Product name
CGP 55845 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0594
Product name
CGP 55845 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$539
Updated
2024/03/01
Tocris
Product number
1248
Product name
CGP 55845 hydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$942
Updated
2021/12/16
Tocris
Product number
1248
Product name
CGP 55845 hydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$225
Updated
2021/12/16
TRC
Product number
C291770
Product name
CGP 55845 hydrochloride
Packaging
100mg
Price
$1040
Updated
2021/12/16
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CGP 55845 Chemical Properties,Usage,Production

Uses

CGP is a potent, selectie GABAB receptor antagonist.

Biological Activity

Potent, selective GABA B receptor antagonist (IC 50 = 5 nM) that prevents agonist binding (pK i = 8.35) and inhibits GABA and glutamate release (pEC 50 values are 8.08 and 7.85 respectively). Inhibits GABA B responses to baclofen (IC 50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro .

Biochem/physiol Actions

CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.

in vitro

antagonist cgp 55845a of the gabab receptor in the presence of cnqx and d(2)-2-amino-5-phosphonovaleric acid prevented the inhibitory postsynaptic potential-b and paired-pulse depression. [3].

IC 50

5 nm

storage

Room temperature

References

[1] waldmeier pc, wicki p, feldtrauer jj, mickel sj, bittiger h, baumann pa. gaba and glutamate release affected by gabab receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. br j pharmacol. 1994 dec;113(4):1515-21.
[2] cunningham md, enna sj. evidence for pharmacologically distinct gabab receptors associated with camp production in rat brain. brain res. 1996 may 13;720(1-2):220-4.
[3] deisz ra. the gaba(b) receptor antagonist cgp 55845a reduces presynaptic gaba(b) actions in neocortical neurons of the rat in vitro. neuroscience. 1999;93(4):1241-9.
[4] zhang m, buttigieg j, nurse ca. neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. j physiol. 2007 feb 1;578(pt 3):735-50. epub 2006 nov 23.
[5] salah a, perkins kl. effects of subtype-selective group i mglur antagonists on synchronous activity induced by 4-aminopyridine/cgp 55845 in adult guinea pig hippocampal slices. neuropharmacology. 2008 jul;55(1):47-54. doi: 10.1016/j.neuropharm.2008.04.010. epub 2008 apr 23.

CGP 55845 Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP 55845 Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
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Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
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Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
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China
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MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
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Shanghai Universal Biotech Co.,Ltd
Tel
13774214275
Email
gaojun@univ-bio.com
Country
China
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24990
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Xi'an Qiyue Biotechnology Co., Ltd.
Tel
400-400-6966-012-012 17778955912
Email
2957605606@qq.com
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China
ProdList
2535
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Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
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China
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Nanjing Tengyi Biotechnology Co., Ltd
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025-58851786 17714337195
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sales@tybiochem.com
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China
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Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
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149184-22-5, CGP 55845Related Search:


  • CGP 55845
  • (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
  • CGP 55845 hydrochloride
  • (2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID
  • benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid
  • CGP 55845 hydrochlor
  • 149184-22-5
  • C18H22Cl2NO3PHCl
  • C18H23Cl3NO3P
  • GABA/Glycine receptor