CGP 55845

Product Name: CGP 55845
CAS No.: 149184-22-5
Chemical Name: CGP 55845
Synonyms: CGP 55845;CGP 55845 hydrochlor;CGP 55845 hydrochloride;benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;(2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID;(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
CBNumber: CB0718390
Molecular Formula: C18H23Cl3NO3P
Formula Weight: 438.71
MOL File: 149184-22-5.mol

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CGP 55845 Property

storage temp.: room temp
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige

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Safety

WGK Germany: 3
RTECS: SZ4680000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0594
Product name: CGP 55845 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0594
Product name: CGP 55845 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $539
Updated: 2024/03/01

Tocris

Product number: 1248
Product name: CGP 55845 hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $942
Updated: 2021/12/16

Tocris

Product number: 1248
Product name: CGP 55845 hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $225
Updated: 2021/12/16

TRC

Product number: C291770
Product name: CGP 55845 hydrochloride
Packaging: 100mg
Price: $1040
Updated: 2021/12/16

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CGP 55845 Chemical Properties,Usage,Production

Uses

CGP is a potent, selectie GABAB receptor antagonist.

Biological Activity

Potent, selective GABA B receptor antagonist (IC 50 = 5 nM) that prevents agonist binding (pK i = 8.35) and inhibits GABA and glutamate release (pEC 50 values are 8.08 and 7.85 respectively). Inhibits GABA B responses to baclofen (IC 50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro .

Biochem/physiol Actions

CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.

in vitro

antagonist cgp 55845a of the gabab receptor in the presence of cnqx and d(2)-2-amino-5-phosphonovaleric acid prevented the inhibitory postsynaptic potential-b and paired-pulse depression. [3].

IC 50

5 nm

storage

Room temperature

References

[1] waldmeier pc, wicki p, feldtrauer jj, mickel sj, bittiger h, baumann pa. gaba and glutamate release affected by gabab receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. br j pharmacol. 1994 dec;113(4):1515-21.
[2] cunningham md, enna sj. evidence for pharmacologically distinct gabab receptors associated with camp production in rat brain. brain res. 1996 may 13;720(1-2):220-4.
[3] deisz ra. the gaba(b) receptor antagonist cgp 55845a reduces presynaptic gaba(b) actions in neocortical neurons of the rat in vitro. neuroscience. 1999;93(4):1241-9.
[4] zhang m, buttigieg j, nurse ca. neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. j physiol. 2007 feb 1;578(pt 3):735-50. epub 2006 nov 23.
[5] salah a, perkins kl. effects of subtype-selective group i mglur antagonists on synchronous activity induced by 4-aminopyridine/cgp 55845 in adult guinea pig hippocampal slices. neuropharmacology. 2008 jul;55(1):47-54. doi: 10.1016/j.neuropharm.2008.04.010. epub 2008 apr 23.

CGP 55845 Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP 55845 Suppliers

China 12 Germany 2 India 1 Japan 1 United Kingdom 2 United States 5 USA 1 Global 24

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
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Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
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Shanghai Universal Biotech Co.,Ltd

Tel: 18768175414
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Country: China
ProdList: 24998
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Xi'an Qiyue Biotechnology Co., Ltd.

Tel: 400-400-6966-012-012 17778955912
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Country: China
ProdList: 2535
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24024
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Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
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Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
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149184-22-5, CGP 55845Related Search:

Hypophosphorous acid CGP 55845A 1-(3,4-DICHLORO-PHENYL)-ETHYLAMINE 2-(3,4-DICHLORO-BENZYLAMINO)-ETHANOL Benzenemethanamine, 3,4-dichloro-a-methyl-, (S)- (S)-1-(3-Chlorophenyl)ethylamine (S)-1-(4-Chlorophenyl)ethylamine 3-AMINOPROPYL(METHYL)PHOSPHINIC ACID HCL DIETHYLPHOSPHINIC ACID CGP 55845

CGP 55845

(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride

CGP 55845 hydrochloride

(2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID

benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid

CGP 55845 hydrochlor

149184-22-5

C18H22Cl2NO3PHCl

C18H23Cl3NO3P

GABA/Glycine receptor