CGP 55845
- Product Name
- CGP 55845
- CAS No.
- 149184-22-5
- Chemical Name
- CGP 55845
- Synonyms
- CGP 55845;CGP 55845 hydrochlor;CGP 55845 hydrochloride;benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;(2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID;(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
- CBNumber
- CB0718390
- Molecular Formula
- C18H23Cl3NO3P
- Formula Weight
- 438.71
- MOL File
- 149184-22-5.mol
CGP 55845 Property
- storage temp.
- room temp
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
- RTECS
- SZ4680000
N-Bromosuccinimide Price
- Product number
- SML0594
- Product name
- CGP 55845 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- SML0594
- Product name
- CGP 55845 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $539
- Updated
- 2024/03/01
- Product number
- 1248
- Product name
- CGP 55845 hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $942
- Updated
- 2021/12/16
- Product number
- 1248
- Product name
- CGP 55845 hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $225
- Updated
- 2021/12/16
- Product number
- C291770
- Product name
- CGP 55845 hydrochloride
- Packaging
- 100mg
- Price
- $1040
- Updated
- 2021/12/16
CGP 55845 Chemical Properties,Usage,Production
Uses
CGP is a potent, selectie GABAB receptor antagonist.
Biological Activity
Potent, selective GABA B receptor antagonist (IC 50 = 5 nM) that prevents agonist binding (pK i = 8.35) and inhibits GABA and glutamate release (pEC 50 values are 8.08 and 7.85 respectively). Inhibits GABA B responses to baclofen (IC 50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro .
Biochem/physiol Actions
CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.
in vitro
antagonist cgp 55845a of the gabab receptor in the presence of cnqx and d(2)-2-amino-5-phosphonovaleric acid prevented the inhibitory postsynaptic potential-b and paired-pulse depression. [3].
IC 50
5 nm
storage
Room temperature
References
[1] waldmeier pc, wicki p, feldtrauer jj, mickel sj, bittiger h, baumann pa. gaba and glutamate release affected by gabab receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. br j pharmacol. 1994 dec;113(4):1515-21.
[2] cunningham md, enna sj. evidence for pharmacologically distinct gabab receptors associated with camp production in rat brain. brain res. 1996 may 13;720(1-2):220-4.
[3] deisz ra. the gaba(b) receptor antagonist cgp 55845a reduces presynaptic gaba(b) actions in neocortical neurons of the rat in vitro. neuroscience. 1999;93(4):1241-9.
[4] zhang m, buttigieg j, nurse ca. neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. j physiol. 2007 feb 1;578(pt 3):735-50. epub 2006 nov 23.
[5] salah a, perkins kl. effects of subtype-selective group i mglur antagonists on synchronous activity induced by 4-aminopyridine/cgp 55845 in adult guinea pig hippocampal slices. neuropharmacology. 2008 jul;55(1):47-54. doi: 10.1016/j.neuropharm.2008.04.010. epub 2008 apr 23.