Ac-DEVD-CMK

Product Name: Ac-DEVD-CMK
CAS No.: 285570-60-7
Chemical Name: Ac-DEVD-CMK
Synonyms: AC-DEVD-CMK;AC-ASP-GLU-VAL-ASP-CMK;CASPASE-3 INHIBITOR III;AC-ASP-GLU-VAL-ASP-CMK: AC-DEVD-CMK;Ac-Asp-Glu-Val-Asp-chloromethylketone;CASPASE-3 INHIBITOR III ; AC-ASP-GLU-VAL-ASP-CMK;Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt;L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-;N-Acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide
CBNumber: CB0725327
Molecular Formula: C21H31ClN4O11
Formula Weight: 550.94
MOL File: 285570-60-7.mol

More

Less

Ac-DEVD-CMK Property

Boiling point:: 1048.1±65.0 °C(Predicted)
Density: 1.401±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
pka: 3.93±0.19(Predicted)
form: Powder
color: white to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 218750
Product name: Caspase-3 Inhibitor III
Purity: The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 1 mg
Price: $98.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 218750
Product name: Caspase-3 Inhibitor III
Purity: The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 5 mg
Price: $411
Updated: 2025/07/31

Cayman Chemical

Product number: 14465
Product name: Ac-DEVD-CMK
Purity: ≥98%
Packaging: 1mg
Price: $65
Updated: 2021/12/16

Cayman Chemical

Product number: 14465
Product name: Ac-DEVD-CMK
Purity: ≥98%
Packaging: 5mg
Price: $293
Updated: 2021/12/16

ApexBio Technology

Product number: C5528
Product name: Ac-DEVD-CMK
Packaging: 1mg
Price: $90
Updated: 2021/12/16

More

Less

Ac-DEVD-CMK Chemical Properties,Usage,Production

Uses

A potent, cell-permeable, and irreversible inhibitor of caspase-3; also inhibits caspases -6, -7, -8, and -10. Commonly used at concentrations up to 100 M to examine the role of caspase-3-dependent apoptosis

Uses

Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10. It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems.

Biological Activity

ac-devd-cmk is a cell-permeable and irreversible caspase-3 inhibitor [1][2][3].apoptosis is a process of programmed cell death that occurs in multicellular organisms. caspase are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. caspase activation is a major event in apoptosis. caspase-3 cleaves and activates caspases 6 and 7, and is processed and activated by caspases 8, 9, and 10 [1][2][3].ac-devd-cmk (ac-asp-glu-val-asp-ch2cl) is a cell-permeable, irreversible and specific caspase-3 inhibitor. in coronary occlusion/reperfusion rat isolated hearts, ac-devd-cmk reduced infarct size (the percentage of infarction 27.8+3.3% vs control 38.5+2.6%), suggesting that caspase inhibition during early reperfusion protected myocardium against lethal reperfusion injury [1]. in bl41 cells, ac-devd-cmk partially inhibited mn2+-induced apoptosis and parp cleavage, and partially blocked b cell death by 37% even at 100 μm [2]. ac-devd-cmk significantly blocked neurotoxicity at 24 hr after 1 hr of sin-1 exposure and also protected against neurotoxicity at 24 hr after 90 min of zinc (75 μm) exposure. ac-devd-cmk completely blocked sin-1-induced activation of caspase-3 [3].

in vivo

Ac-DEVD-CMK (Caspase-3 Inhibitor III; 25 mg/kg; IP; single dose; 3 hours post-APAP) significantly attenuates Acetaminophen (APAP; HY-66005)-induced liver injury (AILI)^[5].
Ac-DEVD-CMK (25 mg/kg; ip; single dose) significantly attenuates APAP-induced liver injury (AILI) in susceptible Sdc1^?/? mice^[6].

Animal Model:	6- to 8-week-old females and males Sdc1^-/-?mice^[4]
Dosage:	25 mg/kg
Administration:	IP; single dose; 3 hours post-APAP
Result:	Significantly attenuated APAP (ip; 500 or 625 mg/kg)-induced liver injury (AILI), indicating that inhibition of GSK-3β or caspase-3 activity mitigates liver damage.

IC 50

Caspase-3

References

[1]. mocanu mm, baxter gf, yellon dm. caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. br j pharmacol. 2000 may;130(2):197-200.
[2]. schrantz n, blanchard da, mitenne f, et al. manganese induces apoptosis of human b cells: caspase-dependent cell death blocked by bcl-2. cell death differ. 1999 may;6(5):445-53.
[3]. zhang y, wang h, li j, et al. peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. j neurosci. 2004 nov 24;24(47):10616-27.

Ac-DEVD-CMK Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ac-DEVD-CMK Suppliers

China 51 Japan 2 United Kingdom 2 United States 10 Global 65

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

285570-60-7, Ac-DEVD-CMKRelated Search:

AC-DEVD-CHO AC-ESMD-CHO AC-DMQD-CHO

AC-ASP-GLU-VAL-ASP-CMK

AC-DEVD-CMK

CASPASE-3 INHIBITOR III

AC-ASP-GLU-VAL-ASP-CMK: AC-DEVD-CMK

CASPASE-3 INHIBITOR III ; AC-ASP-GLU-VAL-ASP-CMK

N-Acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide

Ac-Asp-Glu-Val-Asp-chloromethylketone

Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt

L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-

285570-60-7

C21H31ClN4O11

Pepetides

peptides

Caspase/Related Products

peptide