ChemicalBook > CAS DataBase List > Ac-DEVD-CMK

Ac-DEVD-CMK

Product Name
Ac-DEVD-CMK
CAS No.
285570-60-7
Chemical Name
Ac-DEVD-CMK
Synonyms
AC-DEVD-CMK;AC-ASP-GLU-VAL-ASP-CMK;CASPASE-3 INHIBITOR III;AC-ASP-GLU-VAL-ASP-CMK: AC-DEVD-CMK;Ac-Asp-Glu-Val-Asp-chloromethylketone;CASPASE-3 INHIBITOR III ; AC-ASP-GLU-VAL-ASP-CMK;Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt;L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-;N-Acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide
CBNumber
CB0725327
Molecular Formula
C21H31ClN4O11
Formula Weight
550.94
MOL File
285570-60-7.mol
More
Less

Ac-DEVD-CMK Property

Boiling point:
1048.1±65.0 °C(Predicted)
Density 
1.401±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO
pka
3.93±0.19(Predicted)
form 
Powder
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
J64442
Product name
Caspase-3 Inhibitor III
Packaging
1mg
Price
$114
Updated
2023/06/20
Alfa Aesar
Product number
J64442
Product name
Caspase-3 Inhibitor III
Packaging
5mg
Price
$333
Updated
2021/12/16
Cayman Chemical
Product number
14465
Product name
Ac-DEVD-CMK
Purity
≥98%
Packaging
1mg
Price
$65
Updated
2021/12/16
Cayman Chemical
Product number
14465
Product name
Ac-DEVD-CMK
Purity
≥98%
Packaging
5mg
Price
$293
Updated
2021/12/16
ApexBio Technology
Product number
C5528
Product name
Ac-DEVD-CMK
Packaging
1mg
Price
$90
Updated
2021/12/16
More
Less

Ac-DEVD-CMK Chemical Properties,Usage,Production

Uses

A potent, cell-permeable, and irreversible inhibitor of caspase-3; also inhibits caspases -6, -7, -8, and -10. Commonly used at concentrations up to 100 M to examine the role of caspase-3-dependent apoptosis

Uses

Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10. It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems.

Biological Activity

ac-devd-cmk is a cell-permeable and irreversible caspase-3 inhibitor [1][2][3].apoptosis is a process of programmed cell death that occurs in multicellular organisms. caspase are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. caspase activation is a major event in apoptosis. caspase-3 cleaves and activates caspases 6 and 7, and is processed and activated by caspases 8, 9, and 10 [1][2][3].ac-devd-cmk (ac-asp-glu-val-asp-ch2cl) is a cell-permeable, irreversible and specific caspase-3 inhibitor. in coronary occlusion/reperfusion rat isolated hearts, ac-devd-cmk reduced infarct size (the percentage of infarction 27.8+3.3% vs control 38.5+2.6%), suggesting that caspase inhibition during early reperfusion protected myocardium against lethal reperfusion injury [1]. in bl41 cells, ac-devd-cmk partially inhibited mn2+-induced apoptosis and parp cleavage, and partially blocked b cell death by 37% even at 100 μm [2]. ac-devd-cmk significantly blocked neurotoxicity at 24 hr after 1 hr of sin-1 exposure and also protected against neurotoxicity at 24 hr after 90 min of zinc (75 μm) exposure. ac-devd-cmk completely blocked sin-1-induced activation of caspase-3 [3].

References

[1]. mocanu mm, baxter gf, yellon dm. caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. br j pharmacol. 2000 may;130(2):197-200.
[2]. schrantz n, blanchard da, mitenne f, et al. manganese induces apoptosis of human b cells: caspase-dependent cell death blocked by bcl-2. cell death differ. 1999 may;6(5):445-53.
[3]. zhang y, wang h, li j, et al. peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. j neurosci. 2004 nov 24;24(47):10616-27.

Ac-DEVD-CMK Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ac-DEVD-CMK Suppliers

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7296
Advantage
58
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6968
Advantage
58
Alpha Biopharmaceuticals Co., Ltd
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58

285570-60-7, Ac-DEVD-CMKRelated Search:


  • AC-ASP-GLU-VAL-ASP-CMK
  • AC-DEVD-CMK
  • CASPASE-3 INHIBITOR III
  • AC-ASP-GLU-VAL-ASP-CMK: AC-DEVD-CMK
  • CASPASE-3 INHIBITOR III ; AC-ASP-GLU-VAL-ASP-CMK
  • N-Acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide
  • Ac-Asp-Glu-Val-Asp-chloromethylketone
  • Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt
  • L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
  • 285570-60-7
  • C21H31ClN4O11
  • Pepetides
  • peptides
  • Caspase/Related Products
  • peptide