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AC-DEVD-CHO

Product Name
AC-DEVD-CHO
CAS No.
169332-60-9
Chemical Name
AC-DEVD-CHO
Synonyms
MF 191;AC-DEVD-CHO;AC-DEVD-ALDEHYDE;AC-DEVD-CHO?, >98%;CASPASE-3 INHIBITOR;Ac-DEVD-CHO acetate;ACETYL-DEVD-ALDEHYDE;Ac-Asp-Glu-Val-Asp-H;CASPASE-3 INHIBITOR I;AC-DEVD-CHO USP/EP/BP
CBNumber
CB6488321
Molecular Formula
C20H30N4O11
Formula Weight
502.47
MOL File
169332-60-9.mol
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AC-DEVD-CHO Property

Boiling point:
1021.1±65.0 °C(Predicted)
Density 
1.374±0.06 g/cm3(Predicted)
RTECS 
EK7643000
storage temp. 
-20°C
solubility 
H2O: 1 mg/mL
pka
4.19±0.10(Predicted)
form 
powder
color 
white
biological source
synthetic
Water Solubility 
H2O: 1mg/mL
Sensitive 
Moisture Sensitive
Sequence
N-Acetyl-Asp-Glu-Val-Asp-al
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
235420
Product name
Caspase-3 Inhibitor I
Packaging
1mg
Price
$122
Updated
2025/07/31
Sigma-Aldrich
Product number
235420
Product name
Caspase-3 Inhibitor I
Packaging
5mg
Price
$488
Updated
2025/07/31
Sigma-Aldrich
Product number
A0835
Product name
N-Acetyl-Asp-Glu-Val-Asp-al
Purity
≥95%, powder
Packaging
1mg
Price
$166
Updated
2025/07/31
Sigma-Aldrich
Product number
A0835
Product name
N-Acetyl-Asp-Glu-Val-Asp-al
Purity
≥95%, powder
Packaging
5mg
Price
$572
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
PEP0000973
Product name
AC-DEVD-CHO
Purity
95.00%
Packaging
1MG
Price
$603.95
Updated
2021/12/16
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AC-DEVD-CHO Chemical Properties,Usage,Production

Uses

Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase

Uses

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Definition

ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.

General Description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

in vivo

Compare with model group, in CI group, the concentrations of serum BUN are decreased significantly at all time points after operation and those of Cr are decreased significantly at 6 hours, then restored to those of the sham group at 12 hours and 24 hours; the concentrations of serum TNF-α, IL-6 are decreased and those of IL-10 are elevated significantly at all time points. [TNF-α (μg/L) 6 hours: 436.2±64.2 vs. 653.6±8.9, 12 hours: 233.4±85.4 vs. 579.7±137.1, 24 hours: 151.0±90.3 vs. 551.0±119.8, IL-6 (μg/L) 6 hours: 1033.2±345.8 vs. 1 595.3±159.4, 12 hours: 366.3±68.3 vs. 1 330.7±249.8, 24 hours: 241.2±208.4 vs. 815.3±572.7, IL-10 (μg/L) 6 hours: 33.6±10.4 vs. 26.6±4.5, 12 hours: 37.2±5.0 vs. 24.5±4.3, 24 hours: 38.3±5.5 vs. 18.2±1.6, all P<0.05]; the renal cell apoptosis rates are decreased significantly at all time points: apoptosis rates 6 hours: (13.9±3.2)% vs. (18.3±1.4)%, 12 hours: (10.5±3.6)% vs. (15.9±3.5)%, 24 hours: (8.4±1.8)% vs.(12.5±2.1)%[5].

IC 50

Caspase 3: 0.23 nM (Ki); Caspase-8: 0.92 nM (Ki); Caspase-7: 1.6 nM (Ki); Caspase-10: 12 nM (Ki); Caspase-1: 18 nM (Ki); Caspase-6: 31 nM (Ki); Caspase-9: 60 nM (Ki); Caspase-4: 132 nM (Ki); Caspase-5: 205 nM (Ki); Caspase-2: 1710 nM (Ki)

AC-DEVD-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-DEVD-CHO Suppliers

China 95 India 1 Switzerland 1 United Kingdom 2 United States 16 Global 115
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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96815
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Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
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China
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12000
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VDM Biochemicals
Tel
0330-2528181
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0330-2528171
Email
sales@vdmbio.com
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United States
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510
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Syntechem Co.,Ltd
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Fax
E-Mail Inquiry
Email
info@syntechem.com
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China
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12984
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BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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12952
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Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
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4747
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58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
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United States
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4861
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Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
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4720
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ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
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China
ProdList
3506
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58
Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
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169332-60-9, AC-DEVD-CHORelated Search:

AC-IETD-CHO N-acetyl aspartyl-glutaMic acid AC-DEVD-CHO BIOTIN-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE AC-DEVD-AMC ORCOKININ AC-DEVD-AFC AC-DEVD-CHO BIOTIN-DEVD-CHO MCA-ASP-GLU-VAL-ASP-ALA-PRO-LYS(DNP)-OH AC-DEVD-PNA CYCLIC ADIPOYL-(6-AMINO)HEXANOYL-DEVD-RHODAMINE 110, TRIETHYLAMINE SALT BIOTIN-X-DEVD-FMK (7-METHOXYCOUMARIN-4-YL)ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPARTYL-L-ALANYL-L-PROLYL-N-EPSILON-(2,4-DINITROPHENYL)-L-LYSINE AMIDE AC-ASP-GLU-VAL-ASP-BETA-NA BIOTINYL-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE ANTI-IP3 RECEPTOR TYPE I NEUTRALIZING PEPTIDE AC-ASP-GLU-VAL-ASP-CHO TFA

  • Ac-DEVD-CHO,N-Acetyl-Asp-Glu-Val-Asp-al, >98%
  • AC-DEVD-CHO?, >98%
  • Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem
  • N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-(2-CARBOXY-1-FORMYLETHYL)-L VALINAMIDE
  • N-AC-ASP-GLU-VAL-ASP-CHO
  • N-ACETYL-ASP-GLU-VAL-ASP-AL
  • N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE)
  • CPP32/APOPAIN INHIBITOR
  • CASPASE-3 INHIBITOR I
  • CASPASE-3 INHIBITOR (ALDEHYDE)
  • ACETYL-DEVD-ALDEHYDE
  • ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPART-1-AL
  • ACETYL-ASP-GLU-VAL-ASP-ALDEHYDE
  • AC-DEVD-CHO
  • AC-DEVD-ALDEHYDE
  • AC-ASP-GLU-VAL-ASP-ALDEHYDE
  • AC-ASP-GLU-VAL-ASP-ALDEHYDE (PSEUDO ACID)
  • AC-ASP-GLU-VAL-ASP-H (ALDEHYDE)
  • AC-ASP-GLU-VAL-ASP-CHO
  • Acetyl-aspartyl-glutamyl-valyl-aspartal
  • CASPASE-3 INHIBITOR
  • CASPASE 3 (APOPAIN) INHIBITOR 1
  • MF 191
  • N-acetyl-Asp-Glu-Val-Asp-Ala
  • (4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxyMethyl)-13-forMyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
  • Ac-Asp-Glu-Val-Asp-H
  • CASPASE-3 INHIBITOR I;N-AC-ASP-GLU-VAL-ASP-CHO;ACETYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTAL
  • L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-
  • N-Acetyl-Asp-Glu-Val-Asp-al >=95%, powder
  • AC-DEVD-CHO USP/EP/BP
  • Ac-DEVD-CHO，N-Acetyl-Asp-Glu-Val-Asp-al
  • Caspase 3 Inhibitor I,Caspase3 Inhibitor I
  • AcDEVDCHO,Ac DEVD CHO
  • Ac-DEVD-CHO acetate
  • 169332-60-9
  • Caspase 10
  • Caspases
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Apoptosis and Cell Cycle
  • BioChemical
  • Inhibitors
  • peptides
  • Caspase 10
  • Caspase 3
  • Caspase 7
  • Caspase 8
  • Caspase Inhibitors
  • Caspase Inhibitors and Substrates
  • Peptides and Proteins
  • Peptides for Cell Biology
  • Protease Inhibitor Specificity Index
  • Protease Inhibitors
  • A to C
  • A-AM
  • Aldehydes
  • and Substrates
  • Apoptosis and Cell Cycle