AC-IETD-CHO

Product Name: AC-IETD-CHO
CAS No.: 191338-86-0
Chemical Name: AC-IETD-CHO
Synonyms: AC-IETD-CHO;AC-IETD-ALDEHYDE;CASPASE 8 INHIBITOR 1;CASPASE-8 INHIBITOR I;AC-ILE-GLU-THR-ASP-CHO;GRANZYME B INHIBITOR II;IETD-CHO, CELL-PERMEABLE;AC-ILE-GLU-THR-ASP-ALDEHYDE;caspase-8 inhibitor inhibitor;AC-ILE-GLU-THR-ASP-H (ALDEHYDE)
CBNumber: CB0372613
Molecular Formula: C21H34N4O10
Formula Weight: 502.52
MOL File: 191338-86-0.mol

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AC-IETD-CHO Property

storage temp.: −20°C
solubility: H₂O: 1 mg/mL
form: powder
color: white
Sequence: Ac-Ile-Glu-Thr-Asp-CHO

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 218773
Product name: Caspase-8 Inhibitor I, Cell-Permeable
Purity: The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 1MG
Price: $312
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FA111074
Product name: Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
Packaging: 5mg
Price: $263
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA111074
Product name: Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
Packaging: 2mg
Price: $132
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA111074
Product name: Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
Packaging: 10mg
Price: $457
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0000987
Product name: CASPASE 8 INHIBITOR 1
Purity: 95.00%
Packaging: 1MG
Price: $612.44
Updated: 2021/12/16

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AC-IETD-CHO Chemical Properties,Usage,Production

Uses

Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].

Biological Activity

Cell permeable: yes', 'Primary Target
caspase-8', 'Product does not compete with ATP.', 'Reversible: yes

References

[1] Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17. DOI:10.1093/toxsci/58.1.109
[2] Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. DOI:10.1046/j.1525-1373.2000.22518.x

AC-IETD-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-IETD-CHO Suppliers

China 62 Japan 4 Switzerland 1 United Kingdom 4 United States 19 USA 1 Global 91

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

Nanchang Tianzhen Biotechnology Co., Ltd

Tel: 13758194781 13173652190
Email: 522013271@qq.com
Country: China
ProdList: 2395
Advantage: 58

191338-86-0, AC-IETD-CHORelated Search:

AC-VEID-AMC AC-VDVAD-CHO AC-DEVD-CHO AC-LEVD-CHO AC-LEHD-CHO GRANZYME B AC-IETD-PNA AC-IETD-CHO AC-IETD-AFC CASPASE 3 (163-175) AC-ILE-GLU-THR-ASP-CHO TFA

GRANZYME B INHIBITOR II, CELL-PERMEABLE

AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-ILE-GLU-THR-ASP-CHO

ACETYL-L-ISOLEUCYL-L-GLUTAMYL-L-THREONYL-L-ASPART-1-AL

N-ACETYL-ILE-GLU-THR-ASP-CHO (ALDEHYDE)

Acetyl-isoleucyl-glutamyl-threonyl-aspartal

N-Acetyl-Ile-Glu-Thr-Asp-al

AC-ILE-GLU-THR-ASP-ALDEHYDE

AC-ILE-GLU-THR-ASP-ALDEHYDE (PSEUDO ACID)

AC-ILE-GLU-THR-ASP-CHO

AC-ILE-GLU-THR-ASP-H (ALDEHYDE)

AC-IETD-ALDEHYDE

AC-IETD-CHO

CASPASE-3 PROCESSING ENZYME INHIBITOR (ALDEHYDE)

CASPASE 6/CASPASE 8 INHIBITOR W-1

CASPASE-8 / CASPASE-3 PROCESSING ENZYME INHIBITOR (ALDEHYDE)

CASPASE 8 INHIBITOR 1

CASPASE-8 INHIBITOR I

CASPASE-8 INHIBITOR I, CELL-PERMEABLE

CASPASE-3 PROCESSING ENZYME INHIBITOR I (ALDEHYDE)

IETD-CHO, CELL-PERMEABLE

GRANZYME B INHIBITOR (ALDEHYDE)

GRANZYME B INHIBITOR II

L-Threoninamide, N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-

caspase-8 inhibitor inhibitor

191338-86-0

C21H34N4O10

Inhibitors

Cell Biology

Cell Signaling and Neuroscience

Caspase 3

Caspases

Apoptosis and Cell Cycle

BioChemical

Pepetides

peptides

Caspases/Apoptosis