ChemicalBook > CAS DataBase List > AC-IETD-CHO

AC-IETD-CHO

Product Name
AC-IETD-CHO
CAS No.
191338-86-0
Chemical Name
AC-IETD-CHO
Synonyms
AC-IETD-CHO;AC-IETD-ALDEHYDE;CASPASE 8 INHIBITOR 1;CASPASE-8 INHIBITOR I;AC-ILE-GLU-THR-ASP-CHO;GRANZYME B INHIBITOR II;IETD-CHO, CELL-PERMEABLE;AC-ILE-GLU-THR-ASP-ALDEHYDE;caspase-8 inhibitor inhibitor;AC-ILE-GLU-THR-ASP-H (ALDEHYDE)
CBNumber
CB0372613
Molecular Formula
C21H34N4O10
Formula Weight
502.52
MOL File
191338-86-0.mol
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AC-IETD-CHO Property

storage temp. 
−20°C
solubility 
H2O: 1 mg/mL
form 
powder
color 
white
Sequence
Ac-Ile-Glu-Thr-Asp-CHO
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
218773
Product name
Caspase-8 Inhibitor I, Cell-Permeable
Purity
The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging
1MG
Price
$312
Updated
2025/07/31
Biosynth Carbosynth
Product number
FA111074
Product name
Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
Packaging
5mg
Price
$263
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA111074
Product name
Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
Packaging
2mg
Price
$132
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA111074
Product name
Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
Packaging
10mg
Price
$457
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0000987
Product name
CASPASE 8 INHIBITOR 1
Purity
95.00%
Packaging
1MG
Price
$612.44
Updated
2021/12/16
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AC-IETD-CHO Chemical Properties,Usage,Production

Uses

Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].

Biological Activity

Cell permeable: yes', 'Primary Target
caspase-8', 'Product does not compete with ATP.', 'Reversible: yes

References

[1] Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17. DOI:10.1093/toxsci/58.1.109
[2] Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. DOI:10.1046/j.1525-1373.2000.22518.x

AC-IETD-CHO Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-IETD-CHO Suppliers

China 62 Japan 4 Switzerland 1 United Kingdom 4 United States 19 USA 1 Global 91
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191338-86-0, AC-IETD-CHORelated Search:

AC-VEID-AMC AC-VDVAD-CHO AC-DEVD-CHO AC-LEVD-CHO AC-LEHD-CHO GRANZYME B AC-IETD-PNA AC-IETD-CHO AC-IETD-AFC CASPASE 3 (163-175) AC-ILE-GLU-THR-ASP-CHO TFA

  • GRANZYME B INHIBITOR II, CELL-PERMEABLE
  • AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-ILE-GLU-THR-ASP-CHO
  • ACETYL-L-ISOLEUCYL-L-GLUTAMYL-L-THREONYL-L-ASPART-1-AL
  • N-ACETYL-ILE-GLU-THR-ASP-CHO (ALDEHYDE)
  • Acetyl-isoleucyl-glutamyl-threonyl-aspartal
  • N-Acetyl-Ile-Glu-Thr-Asp-al
  • AC-ILE-GLU-THR-ASP-ALDEHYDE
  • AC-ILE-GLU-THR-ASP-ALDEHYDE (PSEUDO ACID)
  • AC-ILE-GLU-THR-ASP-CHO
  • AC-ILE-GLU-THR-ASP-H (ALDEHYDE)
  • AC-IETD-ALDEHYDE
  • AC-IETD-CHO
  • CASPASE-3 PROCESSING ENZYME INHIBITOR (ALDEHYDE)
  • CASPASE 6/CASPASE 8 INHIBITOR W-1
  • CASPASE-8 / CASPASE-3 PROCESSING ENZYME INHIBITOR (ALDEHYDE)
  • CASPASE 8 INHIBITOR 1
  • CASPASE-8 INHIBITOR I
  • CASPASE-8 INHIBITOR I, CELL-PERMEABLE
  • CASPASE-3 PROCESSING ENZYME INHIBITOR I (ALDEHYDE)
  • IETD-CHO, CELL-PERMEABLE
  • GRANZYME B INHIBITOR (ALDEHYDE)
  • GRANZYME B INHIBITOR II
  • L-Threoninamide, N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-
  • caspase-8 inhibitor inhibitor
  • 191338-86-0
  • C21H34N4O10
  • Inhibitors
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Caspase 3
  • Caspases
  • Apoptosis and Cell Cycle
  • BioChemical
  • Pepetides
  • peptides
  • Caspases/Apoptosis