GRANZYME B
- Product Name
- GRANZYME B
- CAS No.
- 143180-74-9
- Chemical Name
- GRANZYME B
- Synonyms
- GZMB;GRANZYME B;EC 3.4.21.79;GRANZYME B ENZYME;GRANZYME B (HUMAN);Granzyme B from mouse;Granzyme B from Mouse, Recombinant;Granzyme B from Human, Recombinant;SensiZyme Granzyme B Activity Assay Kit;Recombinant Mouse Gzmb Protein, His Tag
- CBNumber
- CB1120279
- Formula Weight
- 0
- MOL File
- Mol file
GRANZYME B Property
- storage temp.
- -70°C
- form
- buffered aqueous solution
- color
- white to off-white
- biological source
- mouse
- Specific Activity
- ≥40units/μg
N-Bromosuccinimide Price
- Product number
- SRP3202
- Product name
- Granzyme B from mouse
- Purity
- recombinant, expressed in Hi-5 Insect cells, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture
- Packaging
- 10 μg
- Price
- $369
- Updated
- 2025/07/31
- Product number
- SRE0021
- Product name
- Granzyme B human
- Purity
- recombinant, expressed in insect cells, ≥90% (SDS-PAGE)
- Packaging
- 5 μg
- Price
- $503
- Updated
- 2025/07/31
- Product number
- 356173
- Product name
- GzmB
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- 356174
- Product name
- Gzmb
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- G8957-15E
- Product name
- Granzyme B
- Packaging
- 100ug
- Price
- $645
- Updated
- 2021/12/16
GRANZYME B Chemical Properties,Usage,Production
General Description
Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations.
Biochem/physiol Actions
Cytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way.
GRANZYME B Preparation Products And Raw materials
Raw materials
Preparation Products
GRANZYME B Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 027-65317797 15926423062
- Fax
- QQ：422450190
- 422450190@qq.com
- Country
- China
- ProdList
- 10308
- Advantage
- 58
- Tel
- 021-60345367 13916550749
- sales@shzbio.com
- Country
- China
- ProdList
- 9965
- Advantage
- 58
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
- Country
- China
- ProdList
- 9868
- Advantage
- 58
- Tel
- 027-87196173
- cusabio@163.com
- Country
- China
- ProdList
- 6066
- Advantage
- 58
- Tel
- 21-20338288
- ordercn@merckgroup.com
- Country
- China
- ProdList
- 6394
- Advantage
- 58
- Tel
- 400-9019800
- sales@bioss.com.cn
- Country
- China
- ProdList
- 6102
- Advantage
- 58
- Tel
- 021-60514606 18321282235
- sale1@shybsw.net
- Country
- China
- ProdList
- 5174
- Advantage
- 58
- Tel
- 1-516-855-7709
- Fax
- 1-631-938-8127
- info@creative-enzymes.com
- Country
- United States
- ProdList
- 8748
- Advantage
- 58