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GRANZYME B

Product Name
GRANZYME B
CAS No.
143180-74-9
Chemical Name
GRANZYME B
Synonyms
GZMB;GRANZYME B;EC 3.4.21.79;GRANZYME B ENZYME;GRANZYME B (HUMAN);Granzyme B from mouse;Granzyme B from Mouse, Recombinant;Granzyme B from Human, Recombinant;Recombinant Mouse Gzmb Protein, His Tag;SensiZyme Granzyme B Activity Assay Kit
CBNumber
CB1120279
Formula Weight
0
MOL File
Mol file
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GRANZYME B Property

storage temp. 
-70°C
form 
buffered aqueous solution
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Safety

Risk Statements 
42/43
Safety Statements 
26-36
WGK Germany 
-
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
356173
Product name
GzmB
Packaging
48Tests
Price
$588
Updated
2021/12/16
Usbiological
Product number
356174
Product name
Gzmb
Packaging
48Tests
Price
$588
Updated
2021/12/16
Usbiological
Product number
G8957-15E
Product name
Granzyme B
Packaging
100ug
Price
$645
Updated
2021/12/16
Usbiological
Product number
G8957-15B-ML750
Product name
Granzyme B
Packaging
100ul
Price
$666
Updated
2021/12/16
Usbiological
Product number
G8957-15B-ML405
Product name
Granzyme B
Packaging
100ul
Price
$666
Updated
2021/12/16
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GRANZYME B Chemical Properties,Usage,Production

General Description

Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations.

Biochem/physiol Actions

Cytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way.

GRANZYME B Preparation Products And Raw materials

Raw materials

Preparation Products

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GRANZYME B Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Wuhan Chemstan Biotechnology Co., Ltd.
Tel
027-65317797 15926423062
Fax
QQ:422450190
Email
422450190@qq.com
Country
China
ProdList
10351
Advantage
58
Shanghai Huzhen Industrial Co., LTD
Tel
021-60345367 13916550749
Email
sales@shzbio.com
Country
China
ProdList
9966
Advantage
58
Biolab Reagents
Tel
027-65279366 18162686757
Email
products@biolabreagent.com
Country
China
ProdList
9818
Advantage
58
Creative Enzymes
Tel
1-516-855-7709
Fax
1-631-938-8127
Email
info@creative-enzymes.com
Country
United States
ProdList
8748
Advantage
58

143180-74-9, GRANZYME BRelated Search:


  • EC 3.4.21.79
  • GRANZYME B (HUMAN)
  • GRANZYME B, HUMAN, CELL CULTURE-DERIVED
  • GRANZYME B ENZYME
  • GRANZYME B
  • GZMB
  • SensiZyme Granzyme B Activity Assay Kit
  • Granzyme B from mouse
  • Granzyme B from Human, Recombinant
  • Granzyme B from Mouse, Recombinant
  • Recombinant Mouse Gzmb Protein, His Tag
  • 143180-74-9
  • BioChemical
  • Apoptosis and Cell Cycle
  • Cell Biology
  • Cathepsins and Granzymes
  • Cell Signaling and Neuroscience
  • Enzymes